Beyond TME Origins

Last updated: October 16, 2024
Sponsor: Imperial College London
Overall Status: Active - Recruiting

Phase

N/A

Condition

Neoplasms

Carcinoma

Adenocarcinoma

Treatment

New Radiological Staging Classification system for patients with advanced and recurrent colorectal cancer undergoing pelvic exenterative surgery

Clinical Study ID

NCT02292641
DOCUMAS: 17HH4158
  • Ages > 16
  • All Genders

Study Summary

All patients with recurrent colorectal cancer in the pelvis are eligible. The original primary tumour staging scans and resected surgical specimen needs to be available. Patients' recurrence will be staged using our proposed MRI classification. We will be assessing the original primary staging scans and histopathology to learn about risk factors for recurrence. We will record treatment for the recurrence, and patients will be followed up for three years.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Had a primary colorectal adenocarcinoma proven by biopsy taken as part of routineclinical practice

  2. Has a confirmed diagnosis of recurrent pelvic colorectal cancer

  3. Has previously completed surgical treatment of primary adenocarcinoma of the colon,sigmoid colon or rectum

  4. Are able to undergo high resolution MRI for staging prior to treatment decisions

  5. Have provided written informed consent to participate in the study

  6. Be aged 16 years or over

Exclusion

Exclusion Criteria:

  1. Have irresectable extra-pelvic metastatic disease

  2. Original baseline staging and preoperative restaging scans (MR for rectal andsigmoid cancers and/or CT for colon and sigmoid cancers) are unavailable

  3. Original preoperative, surgical and adjuvant treatment has not been documented or isunavailable

Study Design

Total Participants: 383
Treatment Group(s): 1
Primary Treatment: New Radiological Staging Classification system for patients with advanced and recurrent colorectal cancer undergoing pelvic exenterative surgery
Phase:
Study Start date:
September 25, 2014
Estimated Completion Date:
December 31, 2031

Study Description

A prospective and retrospective cohort study to improve surgical and treatment planning using an imaging assessment proforma of advanced and recurrent colorectal cancers. This involves the implementation of imaging assessment proformas describing anatomic pelvic compartments and aetiology of disease recurrence for treatment planning.

Connect with a study center

  • Oslo University Hospital

    Oslo, N-0424
    Norway

    Active - Recruiting

  • St Mark's Hospital

    Harrow, London
    United Kingdom

    Active - Recruiting

  • Churchill Hospital

    Oxford, Oxfordshire
    United Kingdom

    Active - Recruiting

  • Royal Marsden Hospital NHS Foundation Trust

    London/Surrey, SM2 5PT
    United Kingdom

    Site Not Available

  • Royal Marsden Hospital NHS Foundation Trust

    Sutton, SM2 5PT
    United Kingdom

    Active - Recruiting

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