Pilot Trial of EGF Ointment for the Patients With EGFR-i Related Skin Side Effects

Inclusion Criteria:

1. Age: older than 20

2. Eastern Cooperative Oncology Group (ECOG) performance status 0 -2

3. Histologically confirmed lung cancer, pancreatic cancer, or colon cancer

4. Patients take EGFR inhibitor following the reason

• EGFR mutation (+) NSCLC - adenocarcinoma for 1st line treatment

• NSCLC - for ≥ 2nd line treatment

• Pancreatic cancer - adenocarcinoma for 1st line treatment with Gemcitabine

• Colon cancer - adenocarcinoma 1st line treatment with Irinotecan (FOLFIRI)

5. Patients who have EGFR inhibitor related skin side effects (ERSE) Gr≥2 (NCICTC V4.0)

6. A patient with the willingness to comply with the study protocol during the studyperiod and capable of complying with it

7. A patient who signed the informed consent prior to the participation of the study andwho understands that he/she has a right to withdrawal from participation in the studyat any time without any disadvantages

Exclusion Criteria:

1. A patient with previous active or passive immunotherapy

2. A pregnant or lactating patient

3. A patient of childbearing potential without being tested for pregnancy at baseline forpositive. (A postmenopausal woman with the amenorrhea period of at least 12 months orlonger is considered to have non-childbearing potential.)

4. A patient with history of uncontrolled seizures, central nervous system disorder orpsychiatric disorders that are considered clinically significant by the investigatorthat would prohibit the understanding of informed consent or that may be considered tointerfere with the compliance of the administration of the study medications

5. A patient with history of dermatologic care (except transient urticaria) within 4weeks

6. A patient with clinically significant (i.e. active) heart disease (e.g. congestiveheart failure, symptomatic coronary artery diseases, cardiac arrhythmias, etc) ormyocardial infarction within past 12 months

7. A patient with interstitial pneumonia or diffused symptomatic fibrosis of the lungs.

8. Organ allogenic transplantation requiring immunosuppressive therapy. Any waiver ofthese inclusion and exclusion criteria must be approved by the investigator and thesponsor on a case-by case basis prior to enrolling the subject

9. Known allergies, hypersensitivity, or intolerance to study drugs, chemotherapy drugsusing this clinical trial