Double Blind Placebo Controlled Controlled Study of Adjuvant MEDI4736 In Completely Resected NSCLC

Last updated: August 11, 2025
Sponsor: Canadian Cancer Trials Group
Overall Status: Active - Not Recruiting

Phase

3

Condition

Non-small Cell Lung Cancer

Treatment

MEDI4736

Placebo

Clinical Study ID

NCT02273375
BR31
ACTRN12615000323527
U1111-1238-5923
IFCT1401
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to find out whether it is better to receive a new drug, MEDI4736, or better to receive no further treatment after surgery (and possibly chemotherapy) for lung cancer.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Histologically confirmed diagnosis of primary non-small cell carcinoma of the lung.according to WHO Classification of Tumours (WHO Classification of Tumours of theLung, Pleura, Thymus and Heart. WHO/IARC Classification of Tumours, 4th Edition,Volume 7). Patients with large-cell neuroendocrine carcinomas are not eligible.

  • Patients must be classified post-operatively as Stage IB (≥ 4cm in the longestdiameter), II or IIIA on the basis of pathologic criteria. Note: Although T3N2M0tumours have been reclassified to stage IIIB in the 8th edition of the IASLC stagingsystem, these patients remain eligible (as stage IIIA under the 7th editioncriteria).

  • Complete surgical resection of the primary NSCLC is also mandatory. All grossdisease must have been removed at the end of surgery. All surgical margins ofresection must be negative for tumour. Resection may be accomplished by open orVATS techniques

Note: Patients with synchronous primary tumours will not be eligible due to the potential uncertainty regarding their appropriate PD-L1 status.

Prior Systemic Therapy:

  • Pre-operative (neo-adjuvant) platinum based or other chemotherapy is notpermissible.

  • Patients may have received prior post-operative platinum based chemotherapy as perstandard of care.

  • No prior anticancer therapy for treatment of NSCLC other than standardpost-operative adjuvant chemotherapy is permissible.

Radiation:

• Patients with N2 disease only who receive adjuvant post-operative radiation therapy are eligible provided they meet the protocol specified timing criteria for surgery, adjuvant chemotherapy and randomization. Pre-operative radiation therapy is not permissible.

  • The patient must have an ECOG performance status of 0, 1.

  • Hematology: . Absolute neutrophil count ≥ 1.5 x 109/L or ≥ 1,500/µl Platelets ≥ 100x 109/L or ≥ 100,000/µl

  • Biochemistry:

Total bilirubin* ≤ institutional upper limit of normal Alkaline phosphatase ≤ 2.5 x institutional upper limit of normal AST(SGOT) and ALT(SGPT) ≤ 2.5 x institutional upper limit of normal Creatinine Clearance ≥ 40 ml/min

  • excluding Gilbert's syndrome

Creatinine clearance to be measured directly by 24 hour urine sampling or as calculated by Cockcroft Formula:

Females: GFR = 1.04 x (140-age) x weight in kg serum creatinine in μmol/L Males: GFR = 1.23 x (140-age) x weight in kg serum creatinine in μmol/L

  • Patient able and willing to complete the QoL, economics and other questionnaires.The baseline assessment must already have been completed within required timelinesprior to randomization. Inability (illiteracy, loss of sight, or other equivalentreason) to complete the questionnaires will not make the patient ineligible for thestudy. However, ability but unwillingness to complete the questionnaires will makethe patient ineligible

  • Patient consent must be appropriately obtained in accordance with applicable localand regulatory requirements. Each patient must sign a consent form prior toenrollment in the trial to document their willingness to participate

  • Patients must be accessible for treatment and follow-up. Investigators must assurethemselves the patients randomized on this trial will be available for completedocumentation of the treatment, adverse events, and follow-up

  • Protocol treatment is to begin within 2 working days of patient randomization

Exclusion

Exclusion Criteria:

  • Patients with a history of other malignancies, except:

  • adequately treated non-melanoma skin cancer,

  • curatively treated in-situ cancer, or

  • other malignancies curatively treated with no evidence of disease for ≥ 5 yearsfollowing the end of treatment and which, in the opinion of the treatingphysician, do not have a substantial risk of recurrence of the priormalignancy.

  • A combination of small cell and non-small cell lung cancer, pulmonary carcinoidtumour or large-cell neuroendocrine carcinoma (LCNEC).

  • History of autoimmune disease, including but not limited to myasthenia gravis,myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis,inflammatory bowel disease, vascular thrombosis associated with antiphospholipidsyndrome, Wegener's granulomatosis, Sjögren's syndrome, Guillain-Barré syndrome,multiple sclerosis, vasculitis, or glomerulonephritis. NOTE: patients with Grave'sdisease and/or psoriasis not requiring systemic therapy within the last two yearsfrom randomization and patients with hypothyroidism (e.g. following Hashimotosyndrome) stable on hormone replacement are not excluded.

  • History of primary immunodeficiency, history of allogenic organ transplant thatrequires therapeutic immunosuppression and the use of immunosuppressive agentswithin 28 days of randomization* or a prior history of severe (grade 3 or 4) immunemediated toxicity from other immune therapy.

  • Live attenuated vaccination administered within 30 days prior to randomization.

  • History of hypersensitivity to MEDI4736 or any excipient.

  • Patients who have experienced untreated and/or uncontrolled cardiovascularconditions and/or have symptomatic cardiac dysfunction (unstable angina, congestiveheart failure, myocardial infarction within the previous year or cardiac ventriculararrhythmias requiring medication, history of 2nd or 3rd degree atrioventricularconduction defects). Patients with a significant cardiac history, even ifcontrolled, must have a LVEF > 50% within 12 weeks prior to randomization.

  • Concurrent treatment with other investigational drugs or anti-cancer therapy.

  • Patients with active or uncontrolled infections or with serious illnesses or medicalconditions which would not permit the patient to be managed according to theprotocol. This includes but is not limited to:

  • known clinical diagnosis of tuberculosis;

  • known active hepatitis B infection (positive HBV surface antigen (HBsAg)).Patients with a past or resolved hepatitis B infection (defined as presence ofhepatitis B core antibody (anti-HBc) and absence of HBSAg) are eligible;

  • known active hepatitis C infection. Patients positive for hepatitis C (HCV)antibody are eligible only if polymerase chain reaction is negative for HCVRNA;

  • known human immunodeficiency virus infection (positive HIV antibodies).

  • known pneumonitis or pulmonary fibrosis with clinically significant impairmentof pulmonary function

  • Pregnant or lactating women. Women of childbearing potential must have a urinepregnancy test proven negative within 14 days prior to randomization. Men and womenof child-bearing potential must agree to use adequate contraception.

Study Design

Total Participants: 1415
Treatment Group(s): 2
Primary Treatment: MEDI4736
Phase: 3
Study Start date:
February 24, 2015
Estimated Completion Date:
January 31, 2026

Connect with a study center

  • Campbelltown Hospital

    Campbelltown, New South Wales 2560
    Australia

    Site Not Available

  • Chris O'Brien Lifehouse

    Camperdown, New South Wales 2050
    Australia

    Site Not Available

  • Coffs Habour Health Campus - NCCI

    Coffs Harbour, New South Wales 2450
    Australia

    Site Not Available

  • Gosford Hospital

    Gosford, New South Wales 2250
    Australia

    Site Not Available

  • Nepean Hospital

    Kingswood, New South Wales 2751
    Australia

    Site Not Available

  • St. George Hospital, Cancer Care Centre

    Kogarah, New South Wales 2217
    Australia

    Site Not Available

  • Liverpool Cancer Therapy Centre, Liverpool Hospital

    Liverpool, New South Wales 2170
    Australia

    Site Not Available

  • Northern Cancer Institute St Leonards

    St Leonards, New South Wales 2065
    Australia

    Site Not Available

  • Royal North Shore Hospital

    St. Leonards, New South Wales 2065
    Australia

    Site Not Available

  • Westmead Hospital

    Westmead, New South Wales 2145
    Australia

    Site Not Available

  • Sunshine Coast University Hospital

    Birtinya, Queensland 4575
    Australia

    Site Not Available

  • Princess Alexandra Hospital

    Brisbane, Queensland 4102
    Australia

    Site Not Available

  • The Prince Charles Hospital

    Chermside, Queensland 4032
    Australia

    Site Not Available

  • Nambour General Hospital

    Nambour, Queensland 4560
    Australia

    Site Not Available

  • Royal Adelaide Hospital

    Adelaide, South Australia 5000
    Australia

    Site Not Available

  • Mater Medical Centre

    Brisbane, South, QLD 4101
    Australia

    Site Not Available

  • Royal Hobart Hospital

    Hobart, Tasmania 7000
    Australia

    Site Not Available

  • Monash Medical Centre

    Clayton, Victoria 3168
    Australia

    Site Not Available

  • St. Vincent's Hospital

    Fitzroy, Victoria 3065
    Australia

    Site Not Available

  • Frankston Hospital - Peninsula Oncology Centre

    Frankston, Victoria 3199
    Australia

    Site Not Available

  • Austin Hospital

    Heidelberg, Victoria 3084
    Australia

    Site Not Available

  • Royal Melbourne Hospital Research Foundation

    Parkville, Victoria 3050
    Australia

    Site Not Available

  • Epworth HealthCare - Richmond

    Richmond, Victoria 3121
    Australia

    Site Not Available

  • Border Medical Oncology

    Wodonga, Victoria 3690
    Australia

    Site Not Available

  • Fiona Stanley Hospital

    Murdoch, Western Australia 6150
    Australia

    Site Not Available

  • Sir Charles Gairdner Hospital

    Perth, Western Australia 6009
    Australia

    Site Not Available

  • St John of God Subiaco

    Subiaco, Western Australia 6008
    Australia

    Site Not Available

  • Flinders Medical Center

    Adelaide, 5042
    Australia

    Site Not Available

  • Canberra Hospital

    Garran, ACT 2605
    Australia

    Site Not Available

  • St. Vincent's Hospital

    Victoria, 3065
    Australia

    Site Not Available

  • St. Vincent's Hospital

    Victoria Park, 3065
    Australia

    Site Not Available

  • Suporte Nutricional e Quimioterapia LTDA PRONUTRIR

    Fortaleza, Ceara 60810180
    Brazil

    Site Not Available

  • Hospital Evangelico de Cachoeiro de Itapemirim

    Cachoeiro de Itapemirim, Espirito Santo 29308020
    Brazil

    Site Not Available

  • Cetus Hospital Dia Oncologia

    Belo Horizonte, Minas Gerais 30110-022
    Brazil

    Site Not Available

  • Liga Norte Riograndense Contra o Cancer

    Natal, Rio Grande Do Norte 59075740
    Brazil

    Site Not Available

  • Instituto Tacchini de Pesquisa em Saude

    Bento Goncalves, Rio Grande Do Sul 95700068
    Brazil

    Site Not Available

  • Centro de Oncologia e Radioterapia (COR) Mae de Deus

    Porto Alegre, Rio Grande Do Sul 90110270
    Brazil

    Site Not Available

  • Clinica de Neoplasias Litoral

    Itajai, Santa Catarina 88301220
    Brazil

    Site Not Available

  • Faculdade de Medicina do ABC

    Sao Paulo, Santo Andre 09060870
    Brazil

    Site Not Available

  • Fundacao Faculdade Regional de Medicina

    Sao Jose do Rio Preto, Sao Paulo 15090-000
    Brazil

    Site Not Available

  • Instituto Nacional de Cancer (INCA)

    Rio de Janeiro, 20231050
    Brazil

    Site Not Available

  • MHAT Nadezhda Hospital

    Sofia, 1330
    Bulgaria

    Site Not Available

  • MHAT Serdika - Medical Oncology Clinic

    Sofia, 1003
    Bulgaria

    Site Not Available

  • Medical Centre Synexus

    Sofia, 1784
    Bulgaria

    Site Not Available

  • Tom Baker Cancer Centre

    Calgary, Alberta T2N 4N2
    Canada

    Site Not Available

  • Cross Cancer Institute

    Edmonton, Alberta T6G 1Z2
    Canada

    Site Not Available

  • BCCA - Abbotsford Centre

    Abbotsford, British Columbia V2S 0C2
    Canada

    Site Not Available

  • BCCA - Fraser Valley Cancer Centre

    Surrey, British Columbia V3V 1Z2
    Canada

    Site Not Available

  • BCCA - Vancouver Cancer Centre

    Vancouver, British Columbia V5Z 4E6
    Canada

    Site Not Available

  • CancerCare Manitoba

    Winnipeg, Manitoba R3E 0V9
    Canada

    Site Not Available

  • The Moncton Hospital

    Moncton, New Brunswick E1C 6Z8
    Canada

    Site Not Available

  • Regional Health Authority B, Zone 2

    Saint John, New Brunswick E2L 4L2
    Canada

    Site Not Available

  • Dr. H. Bliss Murphy Cancer Centre

    St. John's, Newfoundland and Labrador A1B 3V6
    Canada

    Site Not Available

  • QEII Health Sciences Centre

    Halifax, Nova Scotia B3H 1V7
    Canada

    Site Not Available

  • Juravinski Cancer Centre at Hamilton Health Sciences

    Hamilton, Ontario L8V 5C2
    Canada

    Site Not Available

  • Kingston Health Sciences Centre

    Kingston, Ontario K7L 2V7
    Canada

    Site Not Available

  • London Regional Cancer Program

    London, Ontario N6A 5W9
    Canada

    Site Not Available

  • Stronach Regional Health Centre at Southlake

    Newmarket, Ontario L3Y 2P9
    Canada

    Site Not Available

  • Lakeridge Health Oshawa

    Oshawa, Ontario L1G 2B9
    Canada

    Site Not Available

  • Ottawa Hospital Research Institute

    Ottawa, Ontario K1H 8L6
    Canada

    Site Not Available

  • Algoma District Cancer Program

    Sault Ste. Marie, Ontario P6B 0A8
    Canada

    Site Not Available

  • Niagara Health System

    St. Catharines, Ontario L2S 0A9
    Canada

    Site Not Available

  • Health Sciences North

    Sudbury, Ontario P3E 5J1
    Canada

    Site Not Available

  • Thunder Bay Regional Health Sciences Centre/Thunder

    Thunder Bay, Ontario P7B 6V4
    Canada

    Site Not Available

  • Humber River Hospital

    Toronto, Ontario M3M 0B2
    Canada

    Site Not Available

  • Odette Cancer Centre

    Toronto, Ontario M4N 3M5
    Canada

    Site Not Available

  • Sinai Health System

    Toronto, Ontario M5G 1X5
    Canada

    Site Not Available

  • University Health Network

    Toronto, Ontario M5G 2M9
    Canada

    Site Not Available

  • PEI Cancer Treatment Centre

    Charlottetown, Prince Edward Island C1A 8T5
    Canada

    Site Not Available

  • Levis, Quebec G6V 3Z1
    Canada

    Site Not Available

  • CHUM-Centre Hospitalier de l'Universite de Montreal

    Montreal, Quebec H2X 3E4
    Canada

    Site Not Available

  • Centre Integre Universitaire De Sante Et De Services

    Montreal, Quebec H4J 1C5
    Canada

    Site Not Available

  • The Jewish General Hospital

    Montreal, Quebec H3T 1E2
    Canada

    Site Not Available

  • The Research Institute of the McGill University

    Montreal, Quebec H4A 3J1
    Canada

    Site Not Available

  • University Institute of Cardiology and

    Quebec City, Quebec G1V 4G5
    Canada

    Site Not Available

  • Allan Blair Cancer Centre

    Regina, Saskatchewan S4T 7T1
    Canada

    Site Not Available

  • Saskatoon Cancer Centre

    Saskatoon, Saskatchewan S7N 4H4
    Canada

    Site Not Available

  • University Institute of Cardiology and

    Quebec, G1V 4G5
    Canada

    Site Not Available

  • Beijing Cancer Hospital

    Beijing, Beijing 100142
    China

    Site Not Available

  • Fujian Province Cancer Hospital

    Fuzhou, Fujian 350014
    China

    Site Not Available

  • Guangdong General Hospital

    Guangzhou, Guangdong 510080
    China

    Site Not Available

  • The Second Affiliated Hosp of Shantou Medical Colleg

    Shantou, Guangdong 515041
    China

    Site Not Available

  • The People Hospital of Guangxi Zhuang Autonomous Reg

    Nanning, Guangxi 530021
    China

    Site Not Available

  • Henan province Cancer Hospital

    Zhengzhou, Henan 450008
    China

    Site Not Available

  • The Second Xiangya Hospital of Central South Univer

    Changsha, Hunan 410011
    China

    Site Not Available

  • The First People Hospital of Yueyang

    Yueyang, Hunan 414000
    China

    Site Not Available

  • Nanjing General Hospital

    Nanjing, Jiangsu 210002
    China

    Site Not Available

  • The Affiliated Hospital Of Xuzhou Medical College

    Xuzhou, Jiangsu 221000
    China

    Site Not Available

  • Xuzhou Central Hospital

    Xuzhou, Jiangsu 221000
    China

    Site Not Available

  • Northern Jiangsu People Hospital

    Yangzhou, Jiangsu 225000
    China

    Site Not Available

  • Shandong Cancer Hospital

    Jinan, Shandong 250000
    China

    Site Not Available

  • The Affiliated Hospital Of Qingdao University

    Qingdao, Shandong 266003
    China

    Site Not Available

  • Zhongshan Hospital Fudan University

    Shanghai, Shanghai 200032
    China

    Site Not Available

  • Yunnan Provincial Cancer Hospital

    Kunming, Yunnan 650118
    China

    Site Not Available

  • Sir run run shaw hospital School of Medicine

    Hangzhou, Zhejiang 310016
    China

    Site Not Available

  • CRLCC - Paoli-Calmette

    Marseille Cedex, BP 156
    France

    Site Not Available

  • Hopital de la Croix-Rousse

    Lyon, Cedex 04 69317
    France

    Site Not Available

  • Centre hospitalier universitaire de Montpellier

    Montpellier, Cedex 05 34295
    France

    Site Not Available

  • AP-HP Hopital Tenon

    Paris, Cedex 20 75970
    France

    Site Not Available

  • Hopital Albert Michallon

    Grenoble, Cedex 9 38043
    France

    Site Not Available

  • CHRU de Tours - Hopital Bretonneau

    Tours, Tours Cedex 9 37044
    France

    Site Not Available

  • CHRU de Tours - Hopital Bretonneau

    Tours Cedex, Tours Cedex 9 37044
    France

    Site Not Available

  • CHU - Angers

    Angers, 49033
    France

    Site Not Available

  • Centre Hospitalier - Avignon

    Avignon, 84000
    France

    Site Not Available

  • Institut Sainte Catherine

    Avignon, 84000
    France

    Site Not Available

  • Bayonne - Centre Hospitalier

    Bayonne, 64100
    France

    Site Not Available

  • Hopital Jean Minjoz

    Besancon Cedex, 25030
    France

    Site Not Available

  • Hopital Avicenne

    Bobigny, CEDEX 93009
    France

    Site Not Available

  • Polyclinique Bordeaux Nord

    Bordeaux, 33077
    France

    Site Not Available

  • Boulogne - Ambroise Pare

    Boulogne, 92104
    France

    Site Not Available

  • Hopital cardio-vasculaire et pneumologique

    Bron, 69677
    France

    Site Not Available

  • Caen - CHU

    Caen, 14000
    France

    Site Not Available

  • Chalon-sur-Saone - Hopital Prive Sainte-Marie

    Chalon-sur-saone, 71100
    France

    Site Not Available

  • Centre Hospitalier de Chambery

    Chambery, 73000
    France

    Site Not Available

  • Centre Hospitalier de Cholet

    Cholet, 49325
    France

    Site Not Available

  • HIA Percy

    Clamart, 92141
    France

    Site Not Available

  • Clermont-Ferrand - CHU

    Clermont-Ferrand, 63003
    France

    Site Not Available

  • Hopital Louis Pasteur

    Colmar, 68024
    France

    Site Not Available

  • Annemasse - Centre Hospitalier Alpes Leman

    Contamine Sur Arve, 74130
    France

    Site Not Available

  • Centre Hospitalier Sud Francilien

    Corbeil-Essone, 91100
    France

    Site Not Available

  • Centre Hospitalier Sud Francilien

    Corbeil-Essonnes, 91100
    France

    Site Not Available

  • Centre Hospitalier Intercommunal de Creteil

    Creteil, 94000
    France

    Site Not Available

  • CHU Hopital du Bocage

    Dijon, 21079
    France

    Site Not Available

  • Centre Hospitalier Intercommunal - Elbeuf

    Elbeuf, 76503
    France

    Site Not Available

  • Centre Hospitalier departemental

    La Roche Sur Yon, 85925
    France

    Site Not Available

  • Versailles - CH Andre Mignot

    Le Chesnay, 78157
    France

    Site Not Available

  • Centre Hospitalier du Mans

    Le Mans, 72037
    France

    Site Not Available

  • Lille - Hopital Calmette

    Lille, 59037
    France

    Site Not Available

  • Centre Hospitalier Lyon Sud

    Lyon, 69495
    France

    Site Not Available

  • Centre Hospitalier les Chanaux

    Macon, 71018
    France

    Site Not Available

  • Hopital Europeen

    Marseille, 13291
    France

    Site Not Available

  • Marseille - Hopital Nord

    Marseille, 13915
    France

    Site Not Available

  • Meaux -CH

    Meaux, 77104
    France

    Site Not Available

  • CH de la Region d'Annecy

    Metz-Tessy, 74370
    France

    Site Not Available

  • Centre Hospitalier de Mulhouse

    Mulhouse, 68070
    France

    Site Not Available

  • Centre Antoine Lacassagne - Nice

    Nice, 06189
    France

    Site Not Available

  • Centre Hospitalier Regional Hopital de la Source

    Orleans, 45000
    France

    Site Not Available

  • Fondation Hopital Saint Joseph

    Paris, 75014
    France

    Site Not Available

  • Hopital Bichat

    Paris, 75877
    France

    Site Not Available

  • Hopital Saint Louis

    Paris, 75010
    France

    Site Not Available

  • Paris - HEGP

    Paris, 75015
    France

    Site Not Available

  • Paris - Institut Curie

    Paris Cedex 5, 75248
    France

    Site Not Available

  • Centre Hospitalier General de Pau

    Pau, 64000
    France

    Site Not Available

  • Centre Hospitalier de Perigueux

    Perigueux, 24019
    France

    Site Not Available

  • Centre Hospitalier Rene Dubos

    Pontoise, 95301
    France

    Site Not Available

  • CHU de Rouen

    Rouen, 76031
    France

    Site Not Available

  • Saint-Brieuc - CHG

    Saint-Brieuc, 22023
    France

    Site Not Available

  • Centre Hospitalier de Saint-Quentin

    Saint-Quentin, 02100
    France

    Site Not Available

  • Institut de Cancerologie de la Loire

    Saint-priest-en-jarez, 42271
    France

    Site Not Available

  • Nouvel Hopital Civil Hopitaux

    Strasbourg, 67091
    France

    Site Not Available

  • Suresnes - Foch

    Suresnes, 92151
    France

    Site Not Available

  • Thonon-les-Bains - Hopital Georges Pianta

    Thonon Les Bains, 74203
    France

    Site Not Available

  • CHITS Toulon Sainte Musse

    Toulon, 83056
    France

    Site Not Available

  • Hopital Larrey

    Toulouse, 31059
    France

    Site Not Available

  • Villefranche sur Saone - CH

    Villefranche Sur Saone, 69655
    France

    Site Not Available

  • Semmelweis University Pulmonology Department

    Budapest, 1125
    Hungary

    Site Not Available

  • AOU Ospedali Riuniti Umberto I

    Torrette, AN 60126
    Italy

    Site Not Available

  • AOU Ospedali Riuniti Umberto I

    Torrette di Ancona, AN 60126
    Italy

    Site Not Available

  • Azienda Ospedaliera San Giuseppe Moscati

    Avellino, AV 83100
    Italy

    Site Not Available

  • IRCCS Ospedale Oncologico Giovanni Paolo II

    Bari, BA 70124
    Italy

    Site Not Available

  • Instituto Clinico Humanitas

    Rozzano (MI), Lombardia 20089
    Italy

    Site Not Available

  • Ospedale S. Paolo - U.O. di Oncologia Medica

    Milano, MI 20142
    Italy

    Site Not Available

  • Azienda Ospedaliera di Perugia Santa Maria

    Perugia, PG 06129
    Italy

    Site Not Available

  • Centro di Riferimento Oncologico - CRO

    Aviano, PN 33081
    Italy

    Site Not Available

  • Fondazione Salvatore Maugeri Oncologia Medica

    Pavia, PV 27100
    Italy

    Site Not Available

  • OUC Oncologia Medica - Presidio Ospedaliero

    Ravenna, RA 48121
    Italy

    Site Not Available

  • Oncologia Medica IRCCS Arcispedale Maria

    Reggio Emilia, RE 42123
    Italy

    Site Not Available

  • Istituti Fisioterapici Ospitalieri IFO Istituto

    Rome, RM 00144
    Italy

    Site Not Available

  • P.O. di Livorno Azienda USL 6

    Livorno, Toscana
    Italy

    Site Not Available

  • A.O. Busto Arsizio - P.O. Saronno

    Saronno, VA 21047
    Italy

    Site Not Available

  • AOU Integrata Verona Policlinico GB

    Verona, VR 37134
    Italy

    Site Not Available

  • U.O. di Oncologia Medica Azienda Ospedaliera G Rummo

    Benevento, 82100
    Italy

    Site Not Available

  • PO A Perrino ASL Brindisi - UOC Oncologia Medica

    Brindisi, 72100
    Italy

    Site Not Available

  • AOU Policlinico Vittorio Emanuele UOC di Oncologia

    Catania, 95125
    Italy

    Site Not Available

  • U.O. di Oncologia Ospedale Villa Scassi

    Genova, 16149
    Italy

    Site Not Available

  • U.O. di Oncologia Ospedale Villa Scassi

    Genova Sampierdarena, 16149
    Italy

    Site Not Available

  • Intstituto Scientifico Romangnolo

    Meldola, 47014
    Italy

    Site Not Available

  • European Institute of Oncology

    Milan, 20141
    Italy

    Site Not Available

  • U.O.C. di Oncologia U.L.S.S. 13

    Mirano, 30035
    Italy

    Site Not Available

  • Azienda Ospedaliera di Rilievo Nazionale

    Napoli, 80131
    Italy

    Site Not Available

  • Dott. Fortunato Ciardiello,Cattedra Oncologia Medica

    Napoli, 80131
    Italy

    Site Not Available

  • Unita Sperimentazioni Cliniche Istituto per lo

    Napoli, 80131
    Italy

    Site Not Available

  • Universita Federico II UOC Oncologia Medica

    Napoli, 80131
    Italy

    Site Not Available

  • UOC Oncologia Medica II Instituto Oncologio Veneto

    Padova, 35128
    Italy

    Site Not Available

  • Azienda USL di Piacenza, Ospedale Gugliemimo Salieto

    Piacenza, 29100
    Italy

    Site Not Available

  • Azienda Ospedaliera S. Camillo-Forlanin

    Rome, 00152
    Italy

    Site Not Available

  • Japanese Red Cross Nagoya Daiichi Hospital

    Nagoya, Aichi 453-8511
    Japan

    Site Not Available

  • Nagoya University Hospital

    Nagoya, Aichi 466-8560
    Japan

    Site Not Available

  • National Cancer Center Hospital East

    Kashiwa, Chiba 277-8577
    Japan

    Site Not Available

  • National Hospital Organization Shikoku Cancer Center

    Matsuyama, Ehime 791-0280
    Japan

    Site Not Available

  • National Hospital Organization Shikoku Cancer Center

    Matsuyama-shi, Ehime 791-0280
    Japan

    Site Not Available

  • Hospital of the University of Occupational and

    Kitakyushu, Fukuoka 807-8556
    Japan

    Site Not Available

  • Gifu Univiesity Hospital

    Gifu-shi, Gifu 501-1194
    Japan

    Site Not Available

  • Gunma University Hospital

    Maebashi, Gunma 371-8511
    Japan

    Site Not Available

  • Gunma University Hospital

    Maebashi-shi, Gunma 371-8511
    Japan

    Site Not Available

  • National Hospital Organization Kure Medical Center

    Kure, Hiroshima 737-0023
    Japan

    Site Not Available

  • National Hospital Organization Kure Medical Center

    Kure-shi, Hiroshima 737-0023
    Japan

    Site Not Available

  • Koube University Hospital

    Kobe-shi, Hyogo 650-0017
    Japan

    Site Not Available

  • Hyogo College of Medicine

    Nishinomiya-shi, Hyogo 663-8501
    Japan

    Site Not Available

  • Kanazawa University Hospital

    Kanazawa, Ishikawa 920-8641
    Japan

    Site Not Available

  • Sendai Kousei Hospital

    Sendai, Miyagi 980-0873
    Japan

    Site Not Available

  • Kurashiki Central Hospital

    Kurashiki, Okayama 710-8602
    Japan

    Site Not Available

  • Kansai Medical University Hospital

    Hirakata, Osaka 573-1191
    Japan

    Site Not Available

  • Kinki University Hospital Faculty of Medicine

    Osaka-Sayama, Osaka 589-8511
    Japan

    Site Not Available

  • National Hospital Organization Kinki-Chuo

    Sakai, Osaka 591-8555
    Japan

    Site Not Available

  • Tottori University Hospital

    Yonago, Tottori 683-8504
    Japan

    Site Not Available

  • National Hospital Organization Yamaguchi

    Ube, Yamaguchi 755-0241
    Japan

    Site Not Available

  • Chiba University Hospital

    Chiba, 260-8677
    Japan

    Site Not Available

  • Kyushu University Hospital

    Fukuoka, 812-8582
    Japan

    Site Not Available

  • National Hospital Organization Kyushu Medical Center

    Fukuoka, 810-8563
    Japan

    Site Not Available

  • Hiroshima City Hiroshima Citizens Hospital

    Hiroshima, 730-8518
    Japan

    Site Not Available

  • Hiroshima University Hospital

    Hiroshima, 734-8551
    Japan

    Site Not Available

  • Osaka City General Hospital

    Osaka, 534-0021
    Japan

    Site Not Available

  • Osaka International Cancer Institute

    Osaka, 537-8511
    Japan

    Site Not Available

  • Juntendo University Hospital

    Tokyo, 113-8431
    Japan

    Site Not Available

  • Tokyo Medical University Hospital

    Tokyo, 160-0023
    Japan

    Site Not Available

  • Kanagawa Cancer Center

    Yokohama City, 241-0815
    Japan

    Site Not Available

  • Chungbuk National University Hospital

    Cheongju, Chungcheongbuk Do 362-711
    Korea, Republic of

    Site Not Available

  • Keimyung University Dongsan Medical Center

    Daegu, Dalseogu 42601
    Korea, Republic of

    Site Not Available

  • Ulsan University Hospital

    Ulsan, Dong gu 682-714
    Korea, Republic of

    Site Not Available

  • Chung Ang University Hospital

    Seoul, Dongjak Gu 156-755
    Korea, Republic of

    Site Not Available

  • Veterans Health Service Medical Center

    Seoul, Gangdong-gu 134-791
    Korea, Republic of

    Site Not Available

  • The Catholic University of Korea Bucheon

    Bucheon, Gyeonggi Do 420-717
    Korea, Republic of

    Site Not Available

  • Ajou University Hospital

    Suwon, Gyeonggi Do 443-380
    Korea, Republic of

    Site Not Available

  • Inje University Ilsan paik Hospital

    Gyeonggi do, 10380
    Korea, Republic of

    Site Not Available

  • Uijeongbu ST Marys Hospital

    Gyeonggi-do, 11765
    Korea, Republic of

    Site Not Available

  • Kangbuk Samsung Hospital

    Seoul, 03181
    Korea, Republic of

    Site Not Available

  • The Catholic University of Korea,

    Seoul, 137-701
    Korea, Republic of

    Site Not Available

  • Universitair medisch centrum Nijmegen st Radboud

    Nijmegen, Gelderland 6525 GA
    Netherlands

    Site Not Available

  • Amphia ziekenhuis

    Breda, Noord Brabant 4818 CK BREDA
    Netherlands

    Site Not Available

  • Tergooi locatie Hilversum

    Hilversum, Noord Holland 1213XZ
    Netherlands

    Site Not Available

  • Isala

    Zwolle, Overijssel 8025 AB
    Netherlands

    Site Not Available

  • Free University Hospital

    Amsterdam,
    Netherlands

    Site Not Available

  • Netherlands Cancer Institute

    Amsterdam, 1066 CX
    Netherlands

    Site Not Available

  • UMC Groningen

    Groningen, 9713 GZ
    Netherlands

    Site Not Available

  • Academical Hospital Maastricht

    Maastricht, 622G HX
    Netherlands

    Site Not Available

  • Erasmus Medical Center (EMC)

    Rotterdam,
    Netherlands

    Site Not Available

  • Auckland City Hospital

    Auckland, 1023
    New Zealand

    Site Not Available

  • Christchurch Hospital

    Christchurch,
    New Zealand

    Site Not Available

  • Klinika Onkologii i Radioterapii Uniwersyteckie

    Gdansk, 80-214
    Poland

    Site Not Available

  • Specjalistyczny Szpital im

    Szczecin, 70 891
    Poland

    Site Not Available

  • Samodzielny Publiczny Szpital Specjalistyczny

    Zakopane, 34 500
    Poland

    Site Not Available

  • Conformal Med Terra HIFU

    Bucharest, 031864
    Romania

    Site Not Available

  • Oncology Institute Bucharest

    Bucharest,
    Romania

    Site Not Available

  • Spitalul de Psihiatrie Dr. Constantin Gorgos

    Bucharest, 30447
    Romania

    Site Not Available

  • Oncological Institute "Ion Chiricuta"

    Cluj-Napoca, 3400
    Romania

    Site Not Available

  • OCH - Ovidius Clinical Hospital

    Constanta, 905900
    Romania

    Site Not Available

  • Centrul de Oncologie Sf Nectarie

    Craiova, 200347
    Romania

    Site Not Available

  • SC Oncolab SRL

    Craiova, 200385
    Romania

    Site Not Available

  • Spital Lotus SRL

    Ploiesti, 100011
    Romania

    Site Not Available

  • National University Hospital

    Singapore, 119074
    Singapore

    Site Not Available

  • Hospital Germans Trias i Pujol

    Badalona, Barcelona 08916
    Spain

    Site Not Available

  • Hospital Mutua de Terrassa

    Terrassa, Barcelona 08221
    Spain

    Site Not Available

  • Hospital Insular de Gran Canaria

    Las Palmas, Gran Canaria 35016
    Spain

    Site Not Available

  • Hospital General de Alicante

    Alicante, 03010
    Spain

    Site Not Available

  • Hoapital Quiron Dexeus

    Barcelona, 08028
    Spain

    Site Not Available

  • Hospital Duran i Reynals

    Barcelona, 08907
    Spain

    Site Not Available

  • Hospital Vall d Hebron

    Barcelona, 08035
    Spain

    Site Not Available

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, 08041
    Spain

    Site Not Available

  • Hospital Teresa Herrera

    Coruna, 15006
    Spain

    Site Not Available

  • Complejo Asistencial Universitario de Leon

    Leon, 24071
    Spain

    Site Not Available

  • Fundacion Jimenez Diaz

    Madrid, 28040
    Spain

    Site Not Available

  • Hospital Clinico San Carlos

    Madrid, 28040
    Spain

    Site Not Available

  • Hospital Puerta de Hierro

    Madrid, 28035
    Spain

    Site Not Available

  • Hospital Universitario la Princesa

    Madrid, 28006
    Spain

    Site Not Available

  • Hospital Son Llatzer

    Palma de Mallorca, 07198
    Spain

    Site Not Available

  • Hospital Universitario de Salamanca

    Salamanca, 37007
    Spain

    Site Not Available

  • Hospital General Universitario de Valencia

    Valencia, 46014
    Spain

    Site Not Available

  • Far Eastern Memorial Hospital

    New Taipei City;, Taiwan; 220
    Taiwan

    Site Not Available

  • Chang-Gung Memorial Hospital - Chiayi

    Chiayi, 613
    Taiwan

    Site Not Available

  • Chang-Gung Memorial Hospital - Chiayi

    Chiayi City, 613
    Taiwan

    Site Not Available

  • Hualien Tzu Chi Hospital

    Hualien, 970
    Taiwan

    Site Not Available

  • Chang-Gung Memorial Hospital - Kaohsiung

    Kaohsiung, 833
    Taiwan

    Site Not Available

  • Kaohsiung Medical University

    Kaohsiung, 807
    Taiwan

    Site Not Available

  • E-Da Hospital

    Kaohsiung City, 82445
    Taiwan

    Site Not Available

  • Taipei Medical University - Shuang Ho Hospital

    New Taipei City, 235
    Taiwan

    Site Not Available

  • China Medical University Hospital

    Taichung, 404
    Taiwan

    Site Not Available

  • Mackay Memorial Hospital

    Taipei, 104
    Taiwan

    Site Not Available

  • Tri-Service General Hospital

    Taipei, 114
    Taiwan

    Site Not Available

  • Veterans General Hospital - Taipei

    Taipei, 112
    Taiwan

    Site Not Available

  • Chang-Gung Memorial Hospital - Linkou

    Tao-Yuan, 333
    Taiwan

    Site Not Available

  • Chang-Gung Memorial Hospital - Linkou

    Taoyuan, 333
    Taiwan

    Site Not Available

  • Chang-Gung Memorial Hospital - Linkou

    Taoyuan City, 333
    Taiwan

    Site Not Available

  • Dnipropetrovsk City Clinical Hospital No.4

    Dnipropetrovsk, 49102
    Ukraine

    Site Not Available

  • Regional Oncology Center

    Sumy, 40004
    Ukraine

    Site Not Available

  • Vinnytsia Regional Clinical Oncology Dispensary

    Vinnitsia, 21029
    Ukraine

    Site Not Available

  • Banner MD Anderson Cancer Center

    Gilbert, Arizona 85234
    United States

    Site Not Available

  • Beaver Medical Group, EPIC Management, L.P.

    Highland, California 92346
    United States

    Site Not Available

  • USC Norris/Comprehensive Cancer Centre

    Los Angeles, California 9003308
    United States

    Site Not Available

  • National Jewish Health

    Denver, Colorado 80206
    United States

    Site Not Available

  • University of Florida

    Gainesville, Florida 32610-0277
    United States

    Site Not Available

  • H. Lee Moffitt Cancer Center

    Tampa, Florida 33612
    United States

    Site Not Available

  • Duke University Medical Center

    Durham, North Carolina 27710
    United States

    Site Not Available

  • Hematology and Oncology Associates of NEPA

    Dunmore, Pennsylvania 18512
    United States

    Site Not Available

  • Thomas Jefferson University

    Philadelphia, Pennsylvania 19107
    United States

    Site Not Available

  • The Reading Hospital Medical Center

    West Reading, Pennsylvania 19611
    United States

    Site Not Available

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