Treatment of Liver Cirrhosis Due to Hepatitis B Virus With Fuzheng Huayu and Entecavir

Inclusion Criteria:

• More than 6 months history of serum positive HBsAg

• Positive HBV-DNA

• Age 18-60

• Ishak fibrosis score of the biopsy within 6 months ≥5, no anti-virus or anti-fibrosisdrug was taken within 6 months.

• Child-Pugh<7 (Stage A)

• The patient or the patient's guardian agrees to participate the trial and sign theinformed Consent Form.

Exclusion Criteria:

• Primary Lamivudine, Adefovir dipivoxil and Entecavir resistance

• Decompensated liver cirrhosis

• HCC

• Liver histology conforming to other chronic liver diseases, such as moderate or severenon-alcoholic fatty liver disease(more than 1/3 steatosis in liver ), chronichepatitis C, chronic hepatitis D, autoimmune hepatitis, primary biliary cholangitis,primary sclerosing cholangitis, inherited metabolic liver disease, drug or toxicinduced liver injury, parasitic infections, alcoholic liver disease.

• Have psychiatric history or uncontrollable epilepsy patient.

• Uncontrollable diabetic patient

• History of hemoglobin disease (such as alpha- or beta-thalassemia, sickle celldisease, spherocytosis) or patients with toxic or autoimmune hemolytic anemia.

• Severe background disease like chronic respiratory failure, circulatory failure,kidney failure etc.

• In situ organ transplantation (such as liver, kidney, lung and heart) or bone marrowtransplantation and stem cell transplantation.

• Immunocompromised patients: such as HIV infection or take immunosuppressor orglucocorticoid (such as cyclosporin, azathioprine, adrenocortical hormone) within 3months or chemotherapy drugs (such as cyclophosphamide, ammonia and cancerchemotherapy) and radioactive therapy.

• Gestation or lactation period women and women who plan to get pregnant during thestudy period.

• Patient who are allergy to the experimental drug.

• Using history of anti-viral or anti-fibrosis drug within 6 months.

• Patients who are participating other trials.

• Other situation where PI thinks the patient should be excluded.