RCT of Two Noncrosslinked Porcine Acellular Dermal Matrices in Ab Wall Reconstruction

Inclusion Criteria:

• Age > 18

• Patients presenting for elective hernia repair, with Ventral Hernia Working Group (VHWG) grade 2 or above (Patients with a hernia who need hernia repair due to herniasize, discomfort, risk of bowel incarceration, effect on physical function), and whohave comorbidities or contamination making the use of synthetic meshcontraindicated)

• Patients deemed to be good surgical candidates, with no active life-threateningcardiac disease, pulmonary disease, renal disease, hematologic disease (patients whocan have a major surgical procedure without an exceedingly high risk of medicalcomplications such as pulmonary edema, myocardial infarction, pulmonary embolism,renal failure, life-threatening bleeding, stroke).

• Patients presenting for resection of large abdominal wall tumors who are expected toundergo have tumor extirpative defect that would require biologic mesh for closure (patients with a large tumor of the abdominal wall who will have a large defect intheir fascia after resection, who need biologic mesh for reinforcement).

Exclusion Criteria:

• Known allergy to porcine products

• Active smokers (within the past 4 weeks) presenting for elective hernia repair

• Patients with active life-threatening cardiac disease, pulmonary disease, renaldisease, hematologic disease presenting for elective hernia repair

• Patients presenting for emergent hernia repair (in the setting of bowelstrangulation, necrosis, penetrating trauma) as it will be difficult to consentthose patients for the study preoperatively

• Patients with severe systemic sepsis

• Patients with frank purulence in the wound