A Study of Evacetrapib (LY2484595) in Participants With High Cholesterol

Last updated: September 25, 2019
Sponsor: Eli Lilly and Company
Overall Status: Terminated

Phase

3

Condition

Dyslipidemia

Hypertriglyceridemia

Hypercholesterolemia

Treatment

N/A

Clinical Study ID

NCT02227784
14502
I1V-MC-EIBH
  • Ages > 18
  • All Genders

Study Summary

The purpose of the ACCENTUATE study is to evaluate whether the study drug known as evacetrapib is effective in treating participants with high cholesterol and atherosclerotic cardiovascular disease (ASCVD) and/or diabetes.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Must be treated with atorvastatin 40 mg/day for at least 30 days prior to screening

  • Have an LDL-C >70 mg/deciliter(dL) or non-HDL-C >100 mg/dL

  • Have screening triglycerides ≤400 mg/dL (≤4.5 millimoles/Liter)

  • Individuals with ASCVD and/or individuals with type 1 or type 2 diabetes

Exclusion

Exclusion Criteria:

  • Have a hemoglobin A1c (HbA1c) >9.5%

  • New York Heart Association (NYHA) class III or IV congestive heart failure

  • History of either a transient ischemic stroke or ischemic stroke <30 days

  • History of acute coronary syndrome (ACS) <30 days

Study Design

Total Participants: 366
Study Start date:
October 01, 2014
Estimated Completion Date:
December 31, 2015

Connect with a study center

  • Research and Cardiovascular Corp.

    Ponce, 00717-1322
    Puerto Rico

    Site Not Available

  • Clinical Research Puerto Rico, Inc.

    San Juan, 00909
    Puerto Rico

    Site Not Available

  • GCM Medical Group PSC

    San Juan, 00909
    Puerto Rico

    Site Not Available

  • Heart Center Research, LLC

    Huntsville, Alabama 35801
    United States

    Site Not Available

  • Desert Clinical Research

    Mesa, Arizona 85213
    United States

    Site Not Available

  • Central Phoenix Med Clinic LLC

    Phoenix, Arizona 85020
    United States

    Site Not Available

  • Advanced Clinical Research

    Carmichael, California 95608
    United States

    Site Not Available

  • Tooraj Joseph Raoof M.D., Inc.

    Encino, California 91436
    United States

    Site Not Available

  • Irvine Clinical Research Center

    Irvine, California 92618
    United States

    Site Not Available

  • VA Long Beach Healthcare System

    Long Beach, California 90822
    United States

    Site Not Available

  • Rancho Cucamonga Clinical

    Rancho Cucamonga, California 91730
    United States

    Site Not Available

  • Encompass Clinical Research

    Spring Valley, California 91978
    United States

    Site Not Available

  • University Clinical Investigators, Inc.

    Tustin, California 92780
    United States

    Site Not Available

  • Diablo Clinical Research

    Walnut Creek, California 94598
    United States

    Site Not Available

  • University of Colorado Health Sciences Center

    Aurora, Colorado 80045-2517
    United States

    Site Not Available

  • Cardiac Research

    Colorado Springs, Colorado 80909
    United States

    Site Not Available

  • ZASA Clinical Research

    Boynton Beach, Florida 33472
    United States

    Site Not Available

  • Cardiology Research Assoc.

    Daytona Beach, Florida 32117
    United States

    Site Not Available

  • Avail Clinical Research LLC

    DeLand, Florida 32720
    United States

    Site Not Available

  • Alan Graff, MD, PA

    Fort Lauderdale, Florida 33308
    United States

    Site Not Available

  • Nature Coast Clinical Research, LLC

    Inverness, Florida 34452
    United States

    Site Not Available

  • Suncoast Research Group, LLC

    Miami, Florida 33135
    United States

    Site Not Available

  • Progressive Medical Research

    Port Orange, Florida 32127
    United States

    Site Not Available

  • Cardiology Partners Clinical Research Institute, LLC

    Wellington, Florida 33449
    United States

    Site Not Available

  • Georgia Heart Specialists

    Covington, Georgia 30014
    United States

    Site Not Available

  • United Osteoporosis Center

    Gainesville, Georgia 30501
    United States

    Site Not Available

  • East West Medical Institute

    Honolulu, Hawaii 96814
    United States

    Site Not Available

  • Solaris Clinical Research

    Meridian, Idaho 83646
    United States

    Site Not Available

  • Northwest Heart Clinical Research, LLC

    Arlington Heights, Illinois 60005
    United States

    Site Not Available

  • Cedar-Crosse Research Center

    Chicago, Illinois 60607
    United States

    Site Not Available

  • Midwest CRC

    Crystal Lake, Illinois 60012
    United States

    Site Not Available

  • Indiana Heart Physicians Inc

    Indianapolis, Indiana 46237
    United States

    Site Not Available

  • Midwest Institute for Clinical Research

    Indianapolis, Indiana 46260
    United States

    Site Not Available

  • Hutchinson Clinic

    Hutchinson, Kansas 67502
    United States

    Site Not Available

  • Community Medical Associates

    Louisville, Kentucky 40205
    United States

    Site Not Available

  • Grace Research

    Bossier, Louisiana 71111
    United States

    Site Not Available

  • Grace Research

    Bossier City, Louisiana 71111
    United States

    Site Not Available

  • Maryland Cardiovascular Specialists

    Baltimore, Maryland 21229
    United States

    Site Not Available

  • Overlea Personal Physicians

    Baltimore, Maryland 21236
    United States

    Site Not Available

  • Cape Cod Research Institute

    Hyannis, Massachusetts 02601
    United States

    Site Not Available

  • ActivMed Practices & Research, Inc

    Methuen, Massachusetts 01844
    United States

    Site Not Available

  • Medex Healthcare Research, Inc.

    Saint Louis, Missouri 63117
    United States

    Site Not Available

  • Palm Research Center

    Las Vegas, Nevada 89128
    United States

    Site Not Available

  • Heart and Vascular Center of New Brunswick LLC

    Somerset, New Jersey 08873
    United States

    Site Not Available

  • Medex Healthcare Research, Inc.

    New York, New York 10036
    United States

    Site Not Available

  • Saratoga Clinical Research LLC

    Saratoga Springs, New York 12866
    United States

    Site Not Available

  • Buffalo Cardiology and Pulmonary Associates, P.C.

    Williamsville, New York 14221
    United States

    Site Not Available

  • Asheville Cardiology Associates

    Asheville, North Carolina 28803
    United States

    Site Not Available

  • Metrolina Internal Medicine, P.A.

    Charlotte, North Carolina 28204
    United States

    Site Not Available

  • High Point Clinical Trials Center

    High Point, North Carolina 27265
    United States

    Site Not Available

  • Boice Willis Clinic, PA

    Rocky Mount, North Carolina 27804
    United States

    Site Not Available

  • PMG Research of Wilmington, LLC

    Wilmington, North Carolina 28401
    United States

    Site Not Available

  • Lillestol Research LLC

    Fargo, North Dakota 58103
    United States

    Site Not Available

  • Aventiv Research

    Columbus, Ohio 43213
    United States

    Site Not Available

  • South Oklahoma Heart Research, LLC

    Oklahoma City, Oklahoma 73135
    United States

    Site Not Available

  • Portland Preventive Cardiology, LLC

    Portland, Oregon 97225
    United States

    Site Not Available

  • Geisinger Medical Center

    Danville, Pennsylvania 17822-2920
    United States

    Site Not Available

  • Geisinger Gray's Woods

    Port Matilda, Pennsylvania 16870
    United States

    Site Not Available

  • Geisinger Medical Center

    Wilkes-Barre, Pennsylvania 18711
    United States

    Site Not Available

  • Partners in Clinical Research

    Cumberland, Rhode Island 02864
    United States

    Site Not Available

  • PMG Research of Charleston, LLC

    Mount Pleasant, South Carolina 29464
    United States

    Site Not Available

  • PMG Research of Charleston, LLC

    Mt. Pleasant, South Carolina 29464
    United States

    Site Not Available

  • Black Hills Cardiovascular Research Group

    Rapid City, South Dakota 57701
    United States

    Site Not Available

  • Holston Medical Group Clinical Research

    Kingsport, Tennessee 37660
    United States

    Site Not Available

  • Innovative Clinical Trials

    San Antonio, Texas 78229
    United States

    Site Not Available

  • Northwest Houston Heart Center

    Tomball, Texas 77375-4536
    United States

    Site Not Available

  • National Clinical Research - Richmond

    Richmond, Virginia 23294
    United States

    Site Not Available

  • Northwest Clinical Research Center

    Bellevue, Washington 98007-4209
    United States

    Site Not Available

  • Kootenai Heart Clinics, LLC

    Spokane, Washington 99204
    United States

    Site Not Available

  • Clinical Investigation Specialists Inc

    Kenosha, Wisconsin 53142
    United States

    Site Not Available

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