Effect of Sodium Bicarbonate Buffered Lidocaine on the Success of IAN Block of Teeth With Irreversible Pulpitis

Last updated: August 29, 2016
Sponsor: Masoud Saatchi
Overall Status: Completed

Phase

3

Condition

Acute And Chronic Dental Pain

Anesthesia

Treatment

N/A

Clinical Study ID

NCT02226913
193396
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Buffering of local anesthetics (alkalinization) has been suggested in achieving pain control. The purpose of this prospective, randomized, double-blind study was to evaluate the effect of adding 0.6 mL 8.4% sodium bicarbonate to 3.0 mL 2% lidocaine with 1: 80,000 epinephrine on the success rate of IAN block for endodontic treatment of mandibular molars with symptomatic irreversible pulpitis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • vital mandibular molar tooth

  • diagnosis of symptomatic irreversible pulpitis

Exclusion

Exclusion Criteria:

  • younger than 18 years old

  • history of significant medical conditions

  • allergies to local anesthetics or sulfites

  • pregnancy

  • taking any medications that might influence anesthetic assessment

  • active sites of pathosis in area of injection

  • inability to give informed consent

Study Design

Total Participants: 80
Study Start date:
February 01, 2013
Estimated Completion Date:
September 30, 2013

Study Description

Some studies have been shown buffering of local anesthetics reduce pain of injection, hasten the onset of anesthesia, and improved success rate of anesthesia. Others reported buffering of local anesthetics cannot reduce pain of injection, hasten the onset of anesthesia, and improve success rate of anesthesia. There are no studies evaluating a sodium bicarbonate-buffered lidocaine formulation for IAN block for teeth with irreversible pulpitis.