Supplementation of Dual Probiotic Strains Reduced Fasting Triglyceride and Enhanced Apolipoprotein A-V Levels

Last updated: August 11, 2014
Sponsor: Yonsei University
Overall Status: Completed

Phase

3

Condition

Hypertriglyceridemia

Treatment

N/A

Clinical Study ID

NCT02215694
probiotics_140801
  • Ages 24-68
  • All Genders

Study Summary

The purpose of this study is to evaluate the effect of dual probiotic strains containing Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 on triglyceride and apolipoprotein A-V.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • nondiabetic (plasma fasting glucose, <126mg/dL; 2-hour plasma glucose, <200mg/dL)

  • borderline to moderate hypertriglyceridemia (plasma triglyceride, 150-500 mg/dL)

Exclusion

Exclusion Criteria:

  • lipid-lowering medications use

  • any medications or supplement use

  • any probiotics products use for the past 1 months

  • dyslipidemia

  • diabetes mellitus

  • hypertension

  • liver disease

  • renal disease

  • cardiovascular disease

  • cerebrovascular disease

  • pancreatitis

  • cancer

  • medication or alcohol abuse

  • pregnant or breast feeding

Study Design

Total Participants: 128
Study Start date:
June 01, 2012
Estimated Completion Date:
March 31, 2014

Study Description

A randomized, double-blind, placebo-controlled study was conducted on 128 nondiabetic and hypertriglyceridemic (Plasma Triglyceride, 150-500 mg/dL) subjects. Over a 12 week test period, the probiotic group consumed 2g of powder daily containing dual probiotic strains, while the placebo group consumed the same without probiotics.

Connect with a study center

  • Laboratory of Clinical Nutrigenetics/Nutrigenomics

    Seoul, 120-749
    Korea, Republic of

    Site Not Available

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