Role of Parecoxib Sodium for Postoperative Pain Management in Open Hepatectomy

Inclusion Criteria:

• Age between 20-70 years old;

• Hepatic hemangioma patients who will undergo laparotomy surgery: diameter of hepatichemangioma between 5-15cm, located in the right liver;

• Child score 5-6;

• BMI: 19-25;

• ASA: Ⅰ ~ Ⅱ grade;

• No comorbidities such as diabetes, hypertension, cardio renal or respiratorydysfunction, mental illness;

• No known allergies;

• No participation in other clinical trials within 2 months;

• Have been informed consent.

• Surgery-related: right subcostal incision, surgical time< 4 hours, hepatic pedicleocclusion time< 20 minutes, bleeding< 1000ml, no blood transfusions.

Exclusion Criteria:

• History of chronic pain，long-term use of analgesic drugs or alcohol abuse;

• Allergic to NSAIDs, opioids or sulfa drugs;

• Coagulopathy or other hematological disorder；

• Active peptic ulcer, gastrointestinal bleeding, inflammatory bowel disease;

• Pregnant or lactating;

• Mentally unstable to use PCA;

• Preoperative pain caused by other disease;

• Analgesic drugs or NSAIDs intake one week before surgery;

• Preoperative systemic inflammatory response syndrome;

• Preoperative chemotherapy or radiotherapy;

• Preoperative or postoperative use of steroids;

• Operative time> 4 hours, hepatic pedicle occlusion time> 20 minutes, blood loss> 1000ml, or intraoperative blood transfusion;

• TBil> 34 umol/L、PT prolongation> 3S、ALB< 30 g/L、or Child score> 7 within 42 hoursafter surgery；

• Bleeding、biliary fistula, intra-abdominal infections or other postoperativecomplications.