TITAN™ Reverse Shoulder System

Inclusion Criteria:

• Subjects with grossly deficient rotator cuff with severe arthropathy or Subjectswith failed joint replacement with grossly deficient rotator cuff

• Subjects with a shoulder joint anatomically and structurally suited to receive thedevice

• Subjects at least 21 years of age and skeletally mature at the time of surgery

• Subject provided consent to participate in the clinical study (having signed theInformed Consent Form)

Exclusion Criteria:

• Subjects without a functional deltoid muscle

• Subjects with active local or systemic infection

• Subjects with inadequate bone stock in the proximal humerus or glenoid fossa forsupporting the components

• Subjects with poor bone quality such as osteoporosis where there could beconsiderable migration of the prosthesis and/or a chance of fracture of the humerusor glenoid

• Subjects with muscular, neurologic, or vascular deficiencies that compromise theaffected extremity

• Subjects with known metal allergies

• Subjects are known to be at risk for lost to follow-up, or failure to return forscheduled visits

• Subjects who are prisoners

• Female subject who are pregnant, nursing, or of childbearing potential while notpracticing effective contraceptive methods