Antibiotherapy During Therapeutic Hypothermia to Prevent Infectious Complications

Inclusion Criteria:

• Older than 18 years-old, intubated and mechanically ventilated after out-of-hospitalresuscitated cardiac arrest secondary to shockable rhythm

• Hospitalized in an ICU

• Mild therapeutic hypothermia procedure (32° to 35°C) scheduled (24 to 36 hours)

• Delay from ROSC to randomisation < 6 hours

• Consent from family members or emergency consent

Exclusion Criteria:

• Pregnancy

• Out-of-hospital cardiac arrest secondary to non shockable rhythm and In-hospitalcardiac arrest

• Need for cardiac support by cardiopulmonary bypass

• Ongoing antibiotic therapy or during the week before

• Ongoing or concomitant pneumonia

• Known chronic colonization with MRB

• Hypersensitivity to the active substances, to any of the penicillins or to any of theexcipients.

• History of a severe immediate hypersensitivity reaction (e.g. anaphylaxis) to anotherbeta-lactam agent (e.g. a cephalosporin, carbapenem or monobactam).

• History of jaundice/hepatic impairment due to amoxicillin/clavulanic acid, accordingto the latest version of the SmPC.

• Previous lung disease

• Predictable decision of early care limitation

• Patient under guardianship or curatorship

• Moribund patient

• Participation to another trial within 30 days