Comparing Soybean Oil-Based (Intralipid) With an Olive Oil-Based (ClinOleic) Lipid Emulsion on Healthy Volunteers

Last updated: December 18, 2014
Sponsor: Emory University
Overall Status: Completed

Phase

2/3

Condition

Stress

Allergy

Allergy (Pediatric)

Treatment

N/A

Clinical Study ID

NCT02185729
IRB00007543
  • Ages 18-65
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Many patients in the hospital who are malnourished or not eating received intravenous feeding or total parenteral nutrition (TPN). Despite improving nutrition, TPN may increase the risk of infections and hospital complications. We do not know why TPN increases hospital complications, but it may be caused by the high sugar or fat content in TPN solutions. The investigators believe that the high sugar and high fat content can limit the ability to fight infections and produce stiffness of blood vessels. This study will compare the effect of high sugar, high fat content or both on blood sugars, blood vessel function, on blood vessel function. The investigators will also compare the effect of different fats (olive oil and soybean) in the TPN solution on the risk of infection and blood vessel function on a total of 12 healthy subjects.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Healthy males or females, BMI 25 - 35 kg/m2, between the ages of 18 and 65 years

Exclusion

Exclusion Criteria:

  • The patient is pregnant or breast feeding

  • Subjects have or with history of diabetes, hypertension, fasting triglyceride levels > 250 mg/dL, liver disease (ALT 2.5x > upper limit of normal), serum creatinine ≥1.5mg/dL

  • Smokers or ex-smoker < 3 months of cessation, drug or alcohol abuse

  • Mental condition rendering the subject unable to understand the scope and possibleconsequences of the study.

Study Design

Total Participants: 12
Study Start date:
June 01, 2008
Estimated Completion Date:
March 31, 2012

Connect with a study center

  • Grady Memorial Hospital

    Atlanta, Georgia 30303
    United States

    Site Not Available

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