Effect of Vitamin D on Cognitive Decline of Patients With Memory Complaint

Pre-Inclusion Criteria :

• Patients aged 60 years or older,
• Who report to a memory centre with symptoms of memory complaint,
• Having a Mini-Mental State Examination (MMSE) score strictly > the 5th percentile forsociocultural level of the patient (GRECO standards for elderly patients),
• Having visual, hearing abilities (authorized equipment) and an oral or writtenexpression sufficient for the suitable realization of the tests,
• Who accept participation in the study and are able to sign the informed consent of the
• Affiliated to the French social security system. Inclusion Criteria:
• Insufficient 25 OH D serum level : 25 OH D < 50 nmol/L (20 ng/ml),
• Normal corrected plasma calcium concentration,
• Normal kidney function (cockcroft > 30 mL/mn)

Exclusion Criteria:

• Alzheimer's disease or other dementia,
• Parkinson's disease treated,
• Epilepsy treated,
• Huntington's disease,
• Brain tumor,
• History of a progressive disease which may have consequences for the central nervoussystem (blood pressure, higher or equal to 180/100 mmHg, chronic pulmonary diseasewith hypoxia; cerebrovascular accident of less than 3 months, cranial traumatism withpersistent neurologic deficit, subdural hematoma, brain surgery),
• Antecedent of alcoholism or chronic drug-addiction with an obvious or documentedconsequence on cognition,
• Severe depression : score Montgomery Asberg Depression Rating Scale (MADRS) > 18,
• Psychotropic drug therapy (at the discretion of the clinician),
• Hypercalcaemia or treatment for a hypercalcaemia,
• Known hypersensitivity to the vitamin D,
• Granulomatous disease,
• Treatment of vit D at doses higher than the current recommendations,
• History of calcium urinary lithiasis of less than 1 year,
• Nonsteroidal antiinflammatory drug (NSAID) chronic treatment,
• Severe medical or surgical affection of less than 3 months,
• Unstable health, severe hepatic or renal deficiency,
• Deprivation of liberty, under judicial protection,
• Institutionalization (EHPAD),
• Illiteracy,
• Participation in another biomedical research. A diagnosis of MCI (Mild CognitiveImpairment) of less than 6 months is not a criterion of non-inclusion.