SC2i Tissue and Data Repository Protocol

Inclusion Criteria:

• Patients with injury or illness requiring surgical care or treatment in a criticalcare or emergency setting who are being cared for at SC2I sites (Grady MemorialHospital, Emory Univeristy Hospital, and Duke University Health Systems)

• Healthy volunteer control subjects to include individuals without any known injuryor end-stage organ disease and patients who have recovered from prior injury.

• Ability to understand the purposes and risks of the study and willingly give writteninformed consent, or in the case of incapacitated patients, a willing surrogate ableto give written informed consent.

Exclusion Criteria:

• Any condition that, in the opinion of the attending physician, would place thepatient or volunteer subject at undue risk by participating. Specific conditionsinclude but are not limited to anemia prohibitive of phlebotomy, coagulopathy, ortechnical considerations that would prevent acquisition of sufficient tissue orfluid for clinical use. Acquisition of samples from patients requiring activetransfusion or with transfusion-associated coagulopathy will be considered asappropriate study candidates at the discretion of the attending physician.