Effect of Holly Mangrove Shower Gel in Atopic Dermatitis Patients

Last updated: March 15, 2016
Sponsor: Mahidol University
Overall Status: Completed

Phase

3

Condition

Atopic Dermatitis

Eczema (Atopic Dermatitis)

Rosacea

Treatment

N/A

Clinical Study ID

NCT02178215
Si479/2013
  • Ages > 18
  • All Genders

Study Summary

Atopic dermatitis is a chronic intermittent inflammatory skin disease. Currently, there are many cosmeceutical skin products in which their major action affects skin hydration and skin barrier function. In addition, there are some herbal medication remedies used for the treatment of skin diseases based on the knowledge of Thai traditional medicine. Patients with pruritic rash symptoms who attended the Center of Applied Thai Traditional Medicine, Siriraj Hospital, were prescribed the Holly Mangrove Shower Gel to use and on the follow-up appointment showed significant improvement. Nevertheless, the knowledge of using this herbal medication for treating pruritic skin rash so far has been categorized as folk wisdom and not been confirmed by any clinical-trial study on its efficacy and mechanism of action.

Research teams chose Holly Mangrove Shower Gel containing Acanthus ebracteatus Vahl to act as adjunctive for treating atopic dermatitis. Thus, for the purpose of studying the efficacy of Holly Mangrove Shower Gel containing Acanthus ebracteatus Vahl in improving the skin barrier function in atopic dermatitis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 18 years old or above

  • Diagnosed as atopic dermatitis (Hanafin and Rajka criteria)

  • No active dermatitis within 2 weeks

Exclusion

Exclusion Criteria:

  • Pregnancy or lactation

  • Any other skin diseases on forearms

Study Design

Total Participants: 30
Study Start date:
July 01, 2014
Estimated Completion Date:
February 29, 2016

Study Description

The investigators team research with patients by separate patients into 2 groups and compare among each other. In the first group use placebo, the other group use Holly Mangrove Shower Gel. To compare outcomes, the investigators will measure transepidermal water loss, stratum corneum hydration, skin pH, sebum and wrinkles after using studied gel.

Connect with a study center

  • Siriraj Hospital Mahidol Univeristy

    Bangkok, 10700
    Thailand

    Site Not Available

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