Mannitol Brain Relaxation Effect

Last updated: October 23, 2014
Sponsor: Seoul National University Hospital
Overall Status: Trial Status Unknown

Phase

N/A

Condition

Brain Cancer

Treatment

N/A

Clinical Study ID

NCT02168075
Mannitol
  • Ages 20-80
  • All Genders

Study Summary

Mannitol is widely used in patients with elevated intracranial pressure. In neurosurgical field, especially in large size or with brain edema, it is necessary to decrease brain volume to facilitate surgical approach. In general, 0.25 -1.5g of mannitol per kilogram has been known to decrease ICP effectively. But there are some debates in regard to appropriate dose of mannitol.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients who underwent craniotomy for supratentorial brain tumor under generalanesthesia

Exclusion

Exclusion Criteria:

  • Patient who does not agree to the study

  • Patients with or American Society of Anesthesiologists (ASA) physical status class IVor more

  • Patients with glasgow coma scale (GCS) under 13 points

  • Patients who have hyponatremia or hypernatremia (Na<130 or >150mEq/L)

  • Patients who have congestive heart failure or moderately decreased renal function (GFR <60ml/min/1.73m2)

  • Patients with extraventricular drainage such as external ventricular drain (EVD) orventriculoperitoneal (VP) shunt

  • Patients who already under mannitolization

Study Design

Total Participants: 124
Study Start date:
June 01, 2014
Estimated Completion Date:

Study Description

Previous meta-analysis reported that mannitol has dose-response relationship with intracranial pressure. Another study of Sorani showed dose-response relationship between mannitol and intracranial pressure (ICP) in traumatic brain injury patients.

In this study, authors would investigate that mannitol increments can provide more brain relaxation in patients undergoing craniotomy for supratentorial brain tumor removal.

Connect with a study center

  • Seoul National University of Hospital

    Seoul, 110-799
    Korea, Republic of

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.