Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease

Participants will be classified as either Alzheimer's disease(AD) group, mild cognitiveimpairment(MCI) group, elderly normal controls or young normal controls. Specific inclusioncriteria for each group is described below.

[Inclusion criteria: AD]

• Age : 55 - 90
• Clinical Dementia Rating (CDR)=0.5 or 1
• Diagnostic and Statistical Manual-IV(DSM-IV) criteria for dementia
• National Institute of Aging and the Alzheimer's Association (NIA-AA) Probable ADdementia
• Study partner or caregiver to accompany patient to all scheduled visits
• Written informed consent

[Inclusion criteria: MCI (amnestic)]

• Age : 55 - 90
• Clinical Dementia Rating (CDR)=0.5
• Concern regarding a change in cognition (obtained from the subject, from an informantwho knows the subject, or from a skilled clinician observing the subject)
• Lower performance in episodic memory domains that is greater than would be expectedfor the subject's age and educational background
• Preservation of independence in functional abilities
• Study partner or caregiver to accompany subject to all scheduled visits
• Written informed consent

[Inclusion criteria: Elderly normal controls]

• Age : 55 - 90
• Clinical Dementia Rating (CDR)=0
• Those with contactable Informant
• Written informed consent

[Inclusion criteria: Young normal controls]

• Age : 20 - 55
• Clinical Dementia Rating (CDR)=0
• Written informed consent

[Exclusion criteria: general]

• Past history or presence of major psychiatric illness (e.g. schizophrenia, bipolardisorder, alcohol/substance abuse or dependence, delirium)
• Significant neurologic or medical condition that can influence the mental state
• Contraindications for MRI scan (e.g. pacemaker, claustrophobia)
• Illiteracy
• Significant visual or hearing difficulty
• Taking investigational drug
• In pregnancy or breast-feeding