Comparison of CHS-0214 to Enbrel (Etanercept) in Patients With Rheumatoid Arthritis (RA)

Inclusion Criteria:

• Male or female adults

• RA (Rheumatoid Arthritis) diagnosis for 6 months

• On stable dose of MTX of 8mg to 25mg per week

• Active disease: greater than 6 tender joints, greater than 6 swollen joints,C-reactive protein (CRP) greater than or equal to 0.5mg/dL, and disease activity score (DAS) with 28 joints (DAS28-CRP(4)) greater than or equal to 3.2

Exclusion Criteria:

• Use of prednisone greater than 10mg/day

• Use of greater than one non-steroidal anti-inflammatory drug (NSAID)

• Use of biologic therapies for any cause

• Chemistry and hematology values outside protocol specified range

• Positive QuantiFERON-tuberculosis (TB) Gold Test

• Evidence of active lung disease on chest x-ray

• Major systemic infections

• Presence of significant comorbid conditions

• Known allergy to latex

• Women who are pregnant or nursing