Meaning-Centered Counseling for Chinese Patients Who Are Being Treated for Advanced Cancer

Last updated: March 24, 2025
Sponsor: Memorial Sloan Kettering Cancer Center
Overall Status: Active - Recruiting

Phase

N/A

Condition

Metastatic Cancer

Neoplasms

Treatment

Adaptation of IMCP for Chinese Immigrant Cancer Patients

In-depth Patient Interviews

Individual Meaning-Centered Psychotherapy for Chinese (IMCP-Ch) (For Phase 3 and Phase 4)

Clinical Study ID

NCT02112188
14-076
  • Ages 21-80
  • All Genders

Study Summary

The purpose of the study is to modify a type of counseling called "Individual Meaning Centered Psychotherapy" to meet the needs of Chinese cancer patients. Many cancer patients use counseling or other resources to help cope with the emotional burden of their illnesses. Counseling often helps them cope with cancer by giving them a place to express their feelings. "Meaning-Centered" counseling aims to teach cancer patients how to maintain or even increase a sense of meaning and purpose in their lives, despite cancer.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Phases 1 and 2:

Interview Inclusion Criteria (per self-report):

  • Non-US born;

  • Of Chinese descent;

  • Age 21 years through 80 years;

  • Language spoken: Mandarin and/or English

  • Diagnosis of Stage IV cancer (any type).

Phase 3:

  • Stage III or IV cancer (per self-report or on the MSKCC EMR). If traditional stagingdoes not apply (i.e. for leukemia), we can allow patient deemed by provider to havepoor prognosis/roughly equivalent to Stage III or IV to be referred.

  • Age 18 or older

  • Of Chinese descent

  • Mandarin-speaking

  • Have an estimated life expectancy of at least 6 months (per self-report or on theMSKCC EMR)

  • Resides in New York State or New Jersey

Phase 4:

  • Stage III or IV cancer (per self-report or on the MSKCC EMR). If traditional stagingdoes not apply (i.e. for leukemia), we can allow patient deemed by provider to havepoor prognosis/roughly equivalent to Stage III or IV to be referred.

  • Age 18 or older

  • Of Chinese descent

  • Mandarin-speaking

  • Have an estimated life expectancy of at least 6 months (per referring physicianassessment or on the MSKCC EMR)

  • Resides in New York State or New Jersey

Exclusion

Exclusion Criteria:

Phases 1 and 2:

  • Presence of cognitive impairment disorder (e.g., delirium or dementia) sufficient topreclude meaningful informed consent and/or data collection. The Chinese version ofthe Mini Mental State Examination (MMSE) (46) will be used as a cognitive screeningtool. Patients with MMSE scores below 20 will be excluded. For English speakingpatients we will use the English version of the MMSE.

  • Has a household member who has already participated (or agreed to participate).

Phase 3:

  • Previous participation in Phases 1 or 2 of the study

  • Unable/unwilling to use or no access to a telehealth platform (i.e., telephone orvideoconference)

  • For participants who express interest in RSMI, unable/unwilling to use Zoomvideoconferencing platform

  • Unable or unwilling to commit to up to 16 weeks to complete 6-session interventionand follow-up assessments

  • Major psychiatric illness or cognitive impairment that in the judgment of studyinvestigators or study staff would preclude study participation

  • Patients diagnosed with primary brain tumors (per self-report or on the MSKCC EMR),as they may have difficulty completing the intervention and answering questionnaires

  • Undergoing hematopoietic stem cell transplantation (HSCT) (per self-report or on theMSKCC EMR)

  • Currently in psychotherapeutic treatment (patients being treated with psychotropicmedications will not be excluded, as long as they are not in psychotherapy; per selfreport)

Phase 4:

  • Previous participation in Phases 1, 2, or 3 of the study

  • Unable/unwilling to use or no access to the Zoom videoconferencing platform (required for RSMI)

  • Unable or unwilling to commit to up to 16 weeks to complete 6-session interventionand follow-up assessments

  • Major psychiatric illness or cognitive impairment that in the judgment of studyinvestigators or study staff would preclude study participation

  • Patients diagnosed with primary brain tumors (per self-report or on the MSKCC EMR),as they may have difficulty completing the intervention and answering questionnaires

  • Undergoing hematopoietic stem cell transplantation (HSCT) (per self-report or on theMSKCC EMR)

  • Currently in psychotherapeutic treatment (patients being treated with psychotropicmedications will not be excluded, as long as they are not in psychotherapy; per selfreport)

Study Design

Total Participants: 93
Treatment Group(s): 3
Primary Treatment: Adaptation of IMCP for Chinese Immigrant Cancer Patients
Phase:
Study Start date:
April 01, 2014
Estimated Completion Date:
February 15, 2026

Study Description

Phases 1 and 2: Formative Research and Adaptation This is a study to adapt the IMCP intervention to be culturally and linguistically tailored for Chinese cancer patients. This study will be carried out in two phases: 1) formative research and 2) adaptation. Preliminary formative research has begun in our study exploring community needs and priorities through exemption application X13-034. For this application we will continue the formative research (phase 1) by conducting 12 in-depth interviews with Chinese immigrants with advanced cancer to inform the adaptation of the intervention. Results of the patient in-depth interviews will inform how to adapt the IMCP process and session themes to reflect the needs of the community. In the adaptation phase (phase 2) the Breitbart IMCP research team (including Drs. Breitbart, Lichtenthal, and Applebaum), Drs. Leng, Gany, and Ms. Huang will discuss a priori adaptations to the intervention. Potential changes to the process and content will be discussed. Adaptations will be incorporated in a modified IMCP-Ch treatment manual, therapist checklist/outline and Treatment Integrity Coding Manual.

Phase 3: Proof-of-concept" single-arm pilot trial of IMCP-Ch This phase will feature an open feasibility study using a pretest vs. posttest design, with the intervention to be delivered via telehealth in Mandarin Chinese by a bilingual interventionist or by an English-speaking therapist in English (for bilingual Chinese and English-speaking patients who prefer English) or through English-to-Mandarin Remote Simultaneous Medical Interpretation (RSMI), depending on participants' preference

Added a new phase (Phase 4), to examine the effects of using remote interpreting modalities to deliver IMCP-CH to Mandarin-speaking patients with advanced cancer; and (2) to add a minimum distress level for eligibility in order to align trial eligibility criteria with those employed in prior MCP trials, which used a DistressThermometer (DT) cutoff of >4 to identify patients with clinically significant distress (participants who do not meet this criteria will be enrolled in Phase 3). Phase 4 will employ a three-arm pilot randomized controlled trial (RCT) design to test the feasibility and acceptability of using (1) Remote Consecutive Medical Interpretation (RCMI), (2) Remote Simultaneous Medical Interpretation (RSMI) and (3) bilingual provider (control/gold standard) in delivering IMCP-Ch.

Connect with a study center

  • Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

    Basking Ridge, New Jersey 07920
    United States

    Active - Recruiting

  • Memorial Sloan Kettering Monmouth (Limited Protocol Activities)

    Middletown, New Jersey 07748
    United States

    Active - Recruiting

  • Memorial Sloan Kettering Bergen (Limited Protocol Activities)

    Montvale, New Jersey 07645
    United States

    Active - Recruiting

  • Memorial Sloan Kettering Cancer Center Suffolk- Commack (Limited Protocol Activities)

    Commack, New York 11725
    United States

    Active - Recruiting

  • New York Hospital Queens (NYHQ)

    Flushing, New York 11355
    United States

    Site Not Available

  • Memorial Sloan Kettering Westchester (Limited Protocol Activities)

    Harrison, New York 10604
    United States

    Site Not Available

  • Queens Hospital Center

    Jamaica, New York 11432
    United States

    Site Not Available

  • City College of New York (Data Collection AND Data Analysis)

    New York, New York 10031
    United States

    Active - Recruiting

  • MSK at Ralph Lauren (Limited Protocol Activities)

    New York, New York 10035
    United States

    Active - Recruiting

  • Memorial Sloan Kettering Cancer Center

    New York, New York 10065
    United States

    Active - Recruiting

  • Memorial Sloan Kettering Nassau (Limited Protocol Activities)

    Uniondale, New York 11553
    United States

    Active - Recruiting

  • Memorial Sloan Kettering Westchester (Limited Protocol Activities)

    West Harrison, New York 10604
    United States

    Active - Recruiting

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