Analgesic Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) for Central Neuropathic Pain in Multiple Sclerosis

Phase

Condition

Pain (Pediatric)

Memory Loss

Multiple Sclerosis

Treatment

N/A

Clinical Study ID

NCT02059096

CHU-0179

2013-A01422-43

Ages 18-60
All Genders

Study Summary

This study is designed to evaluate the effect of repetitive Transcranial Magnetic Stimulation (rTMS) in the resolution of chronic pain. Participants will be patients with Multiple Sclerosis suffering from chronic pain of neurological origin.

Eligibility Criteria

Inclusion

Inclusion Criteria:

relapsing-remitting Multiple Sclerosis
18 to 60 years
central neuropathic pain with a DN4 score of 4 or more out of 10
average pain of at least 4/10
presence of pain at least 4 days per week
presence of pain for at least 3 months
stable analgesic treatment

Exclusion

Exclusion Criteria:

relapse during the previous 30 days
contraindication for rTMS
peripheral neuropathic pain
severe depression
epilepsia
resting motor threshold above 75%

Study Design

January 05, 2014

February 28, 2023

Study Description

On the one hand, Multiple Sclerosis (MS) is the most frequent chronic disease generating neurological disability in young adults. Among the many types of disabilities associated with MS, chronic pain is very frequent, especially neuropathic pain. This type of pain is often treatment resistant. Moreover, abnormal intra-cortical excitability has been described in MS patients.

On the other hand, repetitive Transcranial Magnetic Stimulation (rTMS) has shown an analgesic effect in various chronic pain conditions (fibromyalgia, post-stroke, peripheral neuropathic pain). Three groups have shown that analgesia was correlated to defective intra-cortical excitability restoration.

The goal of this study is to compare the analgesic effects of two types of primary Motor cortex (M1) rTMS, namely 10Hz and prolonged continuous Theta-Burst Stimulation (pcTBS), with sham stimulation.

Patients will benefit from 1 daily session per day for 5 consecutive days and from a total follow up of 4 weeks. Pain will be assessed each day and several other signs and symptoms will be repeatedly assessed.

Connect with a study center

CHU Ambroise Paré
Boulogne-Billancourt,
France
Active - Recruiting
CHU de Clermont-Ferrand
Clermont-Ferrand, 63003
France
Active - Recruiting
Hôpital Henri Mondor
Créteil,
France
Active - Recruiting

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