Recurrence Risk Factors of Early-Stage Hepatocellular Carcinoma After Radio Frequency Ablation

Inclusion Criteria:

• 18-70 years old
• The diameter of single tumor should be no more than 5cm, or multiple tumors(less than 3 loci) should be no more than 3cm. No large vascular invasion, no lymph nodes orextrahepatic metastases
• The Classification of patients' liver function is Child - Pugh A or B
• No serious coagulation dysfunction (prothrombin activity < 40% or platelet count < 30000 / mL).
• No refractory ascites.
• The patients can be treated with RFA in clinical
• Primary treatment by RFA should ablate the tumor(s) completely
• The patients are aware of their condition, the treatment of the HCC, and the risksassociated with radiofrequency ablation therapy.
• The patients participant voluntarily and they will sign the informed consent beforethe radiofrequency ablation therapy.

Exclusion Criteria:

• The patients are from abroad, Hong Kong, Macao, Taiwan and other regions, who areimpossible to be follow-up
• The patients who refuse to sign the informed consent
• Tumor emboli existed in main portal vein, ductus hepatics communis and(or) its primarybranch, main hepatic vein and(or) inferior vena cava before operation
• Extrahepatic metastasis, lymph node metastasis
• The patients whom accept systemic chemotherapy, preoperative interventional therapy,and(or) other auxiliary treatment
• The patients with diabetes mellitus, heart disease and(or) other diseases can'ttolerate radiofrequency ablation, or influence postoperative follow-up
• The existence of other type of malignant tumor before or accompanied by HCC
• Primary treatment by RFA do not ablate the tumor(s) completely
• Non-primary liver tumor, such as the liver metastatic carcinoma, cholangiocarcinoma,etc