Study of Nimotuzumab in Combination With Neoadjuvant Chemotherapy for Cervical Cancer

Inclusion Criteria:

1. Age:18-70 years

2. Histological confirmed Cervical squamous cell carcinoma

3. FIGO Stage: IB2-IIIB

4. Tumor lesions and stages are confirmed by the internal medicine, obstetrics andgynecology inspection, including a pelvic exam and abdominal and pelvic CT,.ifnecessary, laparoscopy, cystoscopy and pelvic MRI examination will be taken.

5. At least one lesions can be measured

6. No previous therapy

7. ECOG performance status 0-2

8. Life expectancy of more than 6 months

9. Normal hematology:Haemoglobin≥90g/L,white blood cell(WBC)≥4×109/L Absolute neutrophilcount≥1.5×109/L,platelet count≥100×109/L, normal renal function: serumcreatinine<1.5mg/dl or creatinine clearance rate>60ml/min；normal liverfunction:TBIL≤1.5 ULN, AST and ALT≤1.5 ULN

10. Without lung or heart disease

11. Without active infection

12. Signed informed consent and submit to the organization of research

Exclusion Criteria:

1. Severe systemic or uncontrolled disease, unfit for chemotherapy

2. Neuropathy caused by any reason

3. Psychiatric disease

4. Other malignant tumor

5. Bilateral renal pelvis and ureter hydrocephalus who can't be alleviated by ureteralstent or percutaneous nephrostomy, Abnormal serum creatinine level

6. Infection and severe systemic disease

7. Received other anti EGFR monoclonal antibody treatment

8. Participation in other interventional clinical trials

9. Allergic constitution or history of drug allergy

10. Pregnant or breast-feeding or refused to take contraceptive method

11. Poor compliance