Swiss Liver Venous Thrombosis Study

Last updated: March 14, 2023
Sponsor: University Hospital Inselspital, Berne
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT01983059
SLVTS-SASL-35
  • Ages > 18
  • All Genders

Study Summary

The Liver Venous Thrombosis Study is a prospective observational cohort study aimed at collecting clinical data, patient reported outcomes and biological samples of all patients who have been newly and previously diagnosed with liver venous thrombosis in one of the participating hospitals in- and out-patient clinics of the participating centers in Switzerland. All new patients diagnosed with liver venous thrombosis or patients who are currently being treated in one of the participating centers, will be asked to participate in the study.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age ≥ 18 years

  • Admitted in hospital or attend outpatient clinic

  • Objectively confirmed portal vein thrombosis and/or hepatic vein thrombosis

  • Budd-Chiari-Syndrome (BCS), Non-Cirrhotic Intrahepatic Portal Hypertension (NCIPH), Sinusoidal Obstructive Syndrome (SOS), Other Vascular Diseases (Hepatoportal Sclerosis (HC), Nodular Regenerative Hyperplasia (NRH), Obliterative Portal Venopathy (OPV) or Idiopathic Portal Hypertension (IPH))

  • Subjects willing to provide informed consent

Exclusion Criteria

  • Thrombosis limited to mesenteric or splenic vein

  • Inability to sign consent form

  • Follow-up not possible

  • Cardiovascular, tumoral, pulmonary comorbidity with life expectancy estimated to be less than 6 months

  • Portal vein invasion by hepatocellular carcinoma

Study Design

Total Participants: 500
Study Start date:
March 18, 2014
Estimated Completion Date:
December 31, 2023

Study Description

Background

Outcome measures:

Primary: Liver venous thrombosis recanalization

Secondary: Thrombosis progression, Overall mortality, Major bleeding, Ascites

Objective

  • To start a prospective observational cohort study of Liver Venous Thrombosis patients in Switzerland from their primary diagnosis and already diagnosed patients.

  • To examine long-term medical outcomes in patients with liver venous thrombosis in Switzerland by defining incidence, risk factors and treatment results

  • To prospectively collect data on medical history, serious comorbidities, baseline clinical parameters, imaging results, pathology results, tumor characteristics, treatment, treatment outcomes, hospital stays, interventions and complications.

  • To store in a biobank blood and biological samples, obtained during routine practice

Methods

N/A

Connect with a study center

  • Klinik für Gastroenterologie und Hepatologie, Universtätsspital Basel

    Basel, Kanton Basel 4031
    Switzerland

    Active - Recruiting

  • Department of Clinical Research, Hepatology Research Group

    Bern, Kanton Bern 3010
    Switzerland

    Active - Recruiting

  • Medizinische Klinik - Kantonsspital Baden

    Baden, 5404
    Switzerland

    Active - Recruiting

  • Service de Gastro-entérologie et Hépatologie, Hôpitaux Universtaires de Genève

    Geneva, 1211
    Switzerland

    Site Not Available

  • Service de Gastroentérologie et d'Hépatologie, Centre Hospitalier Universitaire Vaudois

    Lausanne, 1011
    Switzerland

    Active - Recruiting

  • Centro di Epatologia - Clinica Luganese Moncucco

    Lugano, 6900
    Switzerland

    Active - Recruiting

  • Klinik für Gastroenterologie/Hepatologie, Kantonsspital St. Gallen

    St. Gallen, 9007
    Switzerland

    Active - Recruiting

  • Klinik für Gastroenterologie und Hepatologie Universitätsspital Zürich

    Zürich, 8091
    Switzerland

    Active - Recruiting

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