Short Duration Treatment of Non-severe Community Acquired Pneumonia

Inclusion Criteria:

• Subject must be 18 years old or over.

• admitted three days before for Community Acquired Pneumonia (CAP) defined by at leastone clinical sign of pneumonia (dyspnea, cough, mucopurulent sputum, crackling soundon lungs) associated with a temperature >38°C on admission, and a new infiltrateconsistent with pneumonia on chest x-ray, who responded favorably to 3 days oftreatment with β-lactams (third generation injectable cephalosporin oramoxicillin-clavulanate)

• able to take oral medication.

• has given its informed consent.

Exclusion Criteria:

• Creatinin < 30ml/min

• History of jaundice / hepatic impairment associated with amoxicillin / clavulanic acid

• History of hypersensitivity to beta-lactam

• Presence of complications or severity of pneumonia (abscess , significant pleuraleffusion, severe chronic respiratory failure , septic shock, respiratory conditionrequiring the passage resuscitation).

• Known immunocompromised terrain ( asplenia , neutropenia, agammaglobulinemia ,immunosuppressants, graft corticosteroids , myeloma , lymphoma, known HIV , sicklecell anemia , CHILD C cirrhosis).

• Antibiotic treatment exceeding 24 hours prior admission.

• Suspected atypical bacteria requiring combined antibiotics therapy .(Subjects whoreceived a single dose of macrolides or fluoroquinolones emergency will not beexcluded) .

• Legionella suspected on clinical, biological and radiological criteria .

• Subjects with clinical or epidemiological environment leading to suspect ahealthcare-associated pneumonia with antibiotic resistant pathogen.

• Suspicion of pneumonia by aspiration.

• Intercurrent infection requiring antibiotic treatment.

• Pregnant women .

• Breastfeeding .

• Allergy to antibiotics in use.

• Life expectancy <1 month .

• Subject without health insurance.

• Subjects without home adress