PREVACT : Preventive REversal of Vitamine K Antagonist in Minor Craniocerebral Trauma

Inclusion Criteria:

• Admission in an emergency departement for a recent and isolated minor head trauma withat least one of the following characteristic : a period of alteration in the level ofconsciousness, a period of loss of consciousness (< 30 min), a posttraumatic amnesia,persistant posttraumatic headache, repeated vomitting (at least 2 episodes) or anyother neurological sign such a convulsion or a localised neurological sign, wound ofthe scalp or the face testifying of the importance of the cranial trauma...
• Subject receiving anticoagulant treatment with anti-vitamin K for the treatment ofatrial fibrillation (AF)
• Initial ED Glasgow Coma Scale (GCS) score of ≥13
• Achievable follow up
• Informed consent form signed by the patient or if he/she isn't able an emergencyinclusion can be realised.

Exclusion Criteria:

• Delay between the minor head trauma and the possible preventive PCC's administration > 6h
• Subject receiving anticoagulant treatment other than anti vitamin K (heparin,fondaparinux, dabigatran, rivaroxaban, apixaban...)
• Subject receiving anticoagulant treatment for other reason than a AF
• Subject on antiplatelet treatment (except the use of low dose of aspirin (≤ 100mg/day)
• Delocalised biology INR in capillary blood < 1.5 if it's available (only indepartement where this analyse is a usual practice)
• Haemorrhage or suspected haemorrhage other than intracranial which could led to areversion of the anticoagulation
• Head trauma associated with one or further potential haemorrhagic traumatic lesions
• Subject who reject the use of products derived from human blood
• Women who are pregnant
• Subject with any condition that, as judged by the investigator, would place thesubject at increased risk of harm if he/she participated in the study
• Subject without social security registered