Pilot Study of the Effect of Laser on Reversing Chronic Radiation Injury

Inclusion Criteria:

1. Healthy males and females between 18 and 80 years of age with radiation-inducedfibrosis and depigmentation. The fibrosis must have occurred at least 1 year prior tothe date of enrollment.
2. Having suitable areas of treatment: All wounds in the area of interest must be closedfor at least two months. The scars must be deemed stable for a period of 3 months orhave a suitable contralateral control before initiation of treatment. This will bedetermined by objective measurements of scar erythema, pliability, induration,thickness at enrollment and again at 3 months;
3. Fitzpatrick skin types I-VI;
4. Able and willing to comply with all visit, treatment and evaluation schedules andrequirements;
5. Able to understand and provide written informed consent;
6. Pregnant woman can be included because study involves local intervention, no newdrugs.

Exclusion Criteria:

1. Active tanning, including the use of tanning booths, during the course of the study;
2. Prior skin treatment with laser or other devices in the treated area within threemonths of initial treatment or during the course of the study;
3. Adverse reactions to compounds of any external agent (e.g., gels, lotions oranesthetic creams) required for use in the study, if no alternative to the said agentexists;
4. History of collagen vascular disease;
5. Active Herpes Simplex or Zoster at the time of treatment or having experienced morethan three episodes of Herpes Simplex / Zoster eruption within a year of studyenrollment;
6. History of immunosuppression/immune deficiency disorders (including humanimmunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS) oruse of immunosuppressive medications;
7. Having any form of active cancer at the time of enrollment and during the course ofthe study;
8. Significant concurrent illness, such as uncontrolled diabetes (with a hemoglobin A1Cof more than 8) (i.e., any disease state that in the opinion of the Investigator wouldinterfere with the anesthesia, treatment, or healing process); Mentally incompetent,prisoner or evidence of active substance or alcohol abuse;
9. Any condition which, in the Investigator's opinion, would make it unsafe (for thesubject or study personnel) to treat the subject as part of this research study;
10. If it is determined that the contracture is due to a deeper process involving themuscles, ligaments or bones.
11. Patient on chemotherapy (but not tamoxifen or other things that affect wound healing)and also active XRT
12. Participation in another interventional study with potential exposure to aninvestigational drug within past 30 days