Efficacy and Safety Study of Kinerase® for Treatment of Cutaneous Facial Photodamage

Inclusion Criteria:

1. Male and female subjects older than 35 years of age and less than 65 years of age.

2. Subjects with mild, moderate or severe facial photodamage as assessed by a 10-pointscale.

3. Subjects willing to sign an informed consent and adhere to all protocol requirements.

Exclusion Criteria:

1. Male and female subjects with suspected porphyria, systemic or cutaneous erythematosuslupus, or any other photosensitizing disorder or drug-induced photosensitization.

2. Subjects with chronic or recurring skin disease or disorder.

3. Subjects with any active infectious skin disorder (Herpes simplex, molluscumcontagiosum, and facial warts).

4. Subjects with skin cancer of the facial tissues.

5. Subjects who have received any laser/ intense pulsed light (IPL) / chemical peel inthe 2 months preceding the screening visit.

6. Subjects with a history of topical and/or oral isotretinoin use, 6 months prior to thescreening visit.

7. Subjects who have been on topical Retin-A or Renova in the 2 months prior to thescreening visit.

8. Subjects who have used topical alpha-hydroxy acid skin care products in the monthpreceding the screening visit.

9. Subjects currently on any anti-aging products and who wish to continue use of theirproducts.

10. Subjects requiring concurrent treatment that would interfere with the studyassessments.

11. Pregnant or lactating female subjects.