Tofacitinib In Psoriatic Arthritis Subjects With Inadequate Response to TNF Inhibitors

Last updated: September 8, 2017
Sponsor: Pfizer
Overall Status: Completed

Phase

3

Condition

Psoriatic Arthritis

Joint Injuries

Psoriasis And Psoriatic Disorders

Treatment

N/A

Clinical Study ID

NCT01882439
A3921125
2013-001368-46
  • Ages > 18
  • All Genders

Study Summary

To examine the safety and efficacy of tofacitinib in subjects with active psoriatic arthritis who have previously had an inadequate response to at least one TNF inhibitor either due to lack of efficacy or an adverse event.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Active arthritis at screening/baseline as indicated by >/= 3 tender/painful and 3swollen joints

  • Active plaque psoriasis at screening

  • Inadequate efficacy or lack of toleration to previously administered TNF inhibitor

Exclusion

Exclusion Criteria:

  • Non-plaque forms of psoriasis (with exception of nail psoriasis)

  • History of autoimmune rheumatic disease other than PsA; also prior history of orcurrent, rheumatic inflammatory disease other than PsA

Study Design

Total Participants: 395
Study Start date:
August 01, 2013
Estimated Completion Date:
April 30, 2016

Connect with a study center

  • Royal Prince Alfred Hospital, Rheumatology Department

    Camperdown, New South Wales 2050
    Australia

    Site Not Available

  • Rheumatology Research Unit

    Maroochydore, Queensland 4558
    Australia

    Site Not Available

  • Emeritus Research Pty Ltd

    Malvern East, Victoria 3145
    Australia

    Site Not Available

  • Emeritus Research

    Melbourne, Victoria 3145
    Australia

    Site Not Available

  • ZNA Jan Palfijn

    Antwerpen, 2170
    Belgium

    Site Not Available

  • Hospital Erasme - Clinique Universitaire de Bruxelles

    Brussels, 1070
    Belgium

    Site Not Available

  • ReumaClinic

    Genk, 3600
    Belgium

    Site Not Available

  • Universitair Ziekenhuis Gent

    Gent, 9000
    Belgium

    Site Not Available

  • University Hospital Leuven, Department of Rheumatology

    Leuven, 3000
    Belgium

    Site Not Available

  • ZNA Jan Palfijn

    Merksem, 2170
    Belgium

    Site Not Available

  • Pfizer Research & Development Kings Heights Technology Center

    Groton, CT 06340
    Brazil

    Site Not Available

  • Covance Central Laboratory Service

    Indianapolis, In - Usa 462142985
    Brazil

    Site Not Available

  • CMIP: Centro Mineiro de Pesquisa Ltda /

    Juiz de Fora, MG 36010-570
    Brazil

    Site Not Available

  • Biomedical Systems

    St. Louis, Mo - Usa 63043
    Brazil

    Site Not Available

  • CETAC - DIAGNOSTICO POR IMAGEM (image only)

    Curitiba, PR 80240-160
    Brazil

    Site Not Available

  • EDUMED - Educacao em Saude SS LTDA.

    Curitiba, PR 80440-080
    Brazil

    Site Not Available

  • Hospital de Clinicas de Porto Alegre (HCPA) / UFRGS

    Porto Alegre, RS 90035-003
    Brazil

    Site Not Available

  • Clinica Medica Bonfiglioli Ltda. / Clinica Bonfiglioli

    Campinas, SP 13015-001
    Brazil

    Site Not Available

  • Radiologia Clínica de Campinas - RCC (Images only)

    Campinas, São Paulo 13015-240
    Brazil

    Site Not Available

  • Toronto Western Hospital

    Toronto, Ontario M5T 2S8
    Canada

    Site Not Available

  • K. Papp Clinical Research

    Waterloo, Ontario N2J 1C4
    Canada

    Site Not Available

  • West Island Rheumatology Research Associates

    Pointe Claire, Quebec H9R 3J1
    Canada

    Site Not Available

  • Vesalion s.r.o.

    Ostrava, 70200
    Czech Republic

    Site Not Available

  • Medical Plus s.r.o.

    Uherske Hradiste, 68601
    Czechia

    Site Not Available

  • Centre Hospitalier Sud-Francilien (CHSF)

    Corbeil Essonnes, Cedex 91106
    France

    Site Not Available

  • Centre Hospitalier Sud-Francilien - Secretariat de Rhumatologie

    Corbeil-Essonnes, Cedex 91106
    France

    Site Not Available

  • Hopital Avicenne

    Bobigny, 93000
    France

    Site Not Available

  • Rheumazentrum Prof. Dr. med Gunther Neeck

    Bad Doberan, 18209
    Germany

    Site Not Available

  • Charite Universitatsmedizin Berlin - Campus Charite Mitte

    Berlin, 10117
    Germany

    Site Not Available

  • Rheumapraxis Steglitz

    Berlin, 12161
    Germany

    Site Not Available

  • Schlosspark-Klinik

    Berlin, 14059
    Germany

    Site Not Available

  • Universitaetsklinikum Erlangen, Medizinische Klinik 3

    Erlangen, 91054
    Germany

    Site Not Available

  • CIRI - Centrum für innovative Diagnostik und Therapie Rheumatologie/Immunologie (GmbH)

    Frankfurt am Main, 60528
    Germany

    Site Not Available

  • Medizinische Universitatsklinik Freiburg

    Freiburg, 79106
    Germany

    Site Not Available

  • Universitaetsklinikum Des Saarlandes Und Medizinische Fakultaet Der Universitaet Des Saarlandes

    Homburg, 66421
    Germany

    Site Not Available

  • Universitaetsklinikum Schleswig-Holstein Campus Kiel

    Kiel, 24105
    Germany

    Site Not Available

  • University Hospital of Cologne

    Koeln, 50937
    Germany

    Site Not Available

  • Elisabeth Klinik Bigge

    Olsberg, 59939
    Germany

    Site Not Available

  • Hospital Angeles Clinica Londres

    Mexico City, D.F 06700
    Mexico

    Site Not Available

  • Universidad La Salle

    Tlalpan, D.f. 14000
    Mexico

    Site Not Available

  • CLIDITER, S.A. de C.V.

    Mexico, Distrito Federal 06700
    Mexico

    Site Not Available

  • Medica Sur, S.A.B. de C.V. (For Emergencies Only)

    Mexico, Distrito Federal 14050
    Mexico

    Site Not Available

  • Universidad La Salle AC

    Mexico, Distrito Federal 14000
    Mexico

    Site Not Available

  • Grupo Medico Camino S.C.

    Mexico City, Distrito Federal 03310
    Mexico

    Site Not Available

  • Grupo Santa Bernardette S.A. de C.V.

    Guadalaja, Jalisco 44200
    Mexico

    Site Not Available

  • Centro Integral en Reumatologia SA de CV

    Guadalajara, Jalisco 44160
    Mexico

    Site Not Available

  • Grupo Santa Bernardette S.A. de C.V.

    Guadalajara, Jalisco 44200
    Mexico

    Site Not Available

  • Centro de Investigacion de Tratamientos Innovadores de Sinaloa, S.C

    Culiacan, Sinaloa 80000
    Mexico

    Site Not Available

  • Hospital General de Culiacan "Dr. Bernardo J. Gastelum"

    Culiacan, Sinaloa 80230
    Mexico

    Site Not Available

  • Sanatorio CEMSI Chapultepec (For Emergencies Only)

    Culiacan, Sinaloa 80040
    Mexico

    Site Not Available

  • Star Medica S.A. de C.V. (For Emergencies Only)

    Merdia, Yucatan 97133
    Mexico

    Site Not Available

  • Centro Multidisciplinario para el Desarrollo

    Merida, Yucatan 97130
    Mexico

    Site Not Available

  • Centro de Investigacion Clinica Pensiones

    Merida, Yucatan 97070
    Mexico

    Site Not Available

  • Hospital Star Medica Merida (For Emergencies Only)

    Merida, Yucatan 97133
    Mexico

    Site Not Available

  • Institute Medico Panamericano, S.A. de C.V. (For Emergencies Only)

    Merida, Yucatan 97000
    Mexico

    Site Not Available

  • Unidad Reumatologica Las Americas SCP

    Merida, Yucatan 97000
    Mexico

    Site Not Available

  • Christus Muguerza del parque, S.A de C.V

    Chihuahua, 31000
    Mexico

    Site Not Available

  • Investigacion y Biomedicina de Chihuahua

    Chihuahua, 31000
    Mexico

    Site Not Available

  • CLIDITER

    Distrito Federal, 6720
    Mexico

    Site Not Available

  • Centro de Investigacion Clinica Pensiones

    Merida - Yucatan,
    Mexico

    Site Not Available

  • Szpital Uniwersytecki nr 2 im. dr Jana Biziela w Bydgoszczy,

    Bydgoszcz, 85-168
    Poland

    Site Not Available

  • Centrum Kliniczno-Badawcze J.Brzezicki, B.Gornikiewicz-Brzez

    Elblag, 82-300
    Poland

    Site Not Available

  • Centrum Radiologii for X-Ray only

    Elblag, 82-300
    Poland

    Site Not Available

  • NZOZ Centrum Reumatologiczne Indywidualna Specjalistyczna Praktyka Lekarska Lek. Med. Barbara Bazela

    Elblag, 82-300
    Poland

    Site Not Available

  • Wojewodzki Szpital Zespolony Zaklad Radiologii

    Elblag, 82-300
    Poland

    Site Not Available

  • Przychodnia Specjalistyczna Lekarskiej Spozielni Pracy "Medica" for X-Ray Only

    Grodzisk Mazowiecki, 05-825
    Poland

    Site Not Available

  • Specjalistyczne Gabinety Lekarskie "DERMED" Anna Kaszuba

    Lodz, 90-265
    Poland

    Site Not Available

  • Zespól Poradni Specjalistycznych Reumed Filia nr 2 Onyksowa

    Lublin, 20-582
    Poland

    Site Not Available

  • NZOZ Lecznica MAK-MED S.C.

    Nadarzyn, 05-830
    Poland

    Site Not Available

  • Prywatna Praktyka Lekarska Prof. UM dr hab. Pawel Hrycaj

    Poznan, 61-397
    Poland

    Site Not Available

  • Reumatika Centrum Reumatologii nzoz

    Warszawa, 02-691
    Poland

    Site Not Available

  • Synexus Polska Sp. z o.o. Oddz. we Wroclawiu

    Wroclaw, 50-088
    Poland

    Site Not Available

  • Regional State Budgetary Healthcare Institution of Karelia Republic "Republic Hospital n.a.

    Petrozavodsk, Karelia Republic 185019
    Russian Federation

    Site Not Available

  • State Autonomic Healthcare Institution City Clinical Hospital # 7

    Kazan, Republic of Tatarstan, Russia 420103
    Russian Federation

    Site Not Available

  • Municipal Budgetary Institution Central City Clinical Hospital #6

    Ekaterinburg, Russia 620149
    Russian Federation

    Site Not Available

  • OOO AVA-PETER Scandinavia clinic

    Saint Petersburg, Russia 191014
    Russian Federation

    Site Not Available

  • SBIH of Moscow "City Clinical Hospital#1 n. a. N.I. Pirogov" of the Healthcare Department of Moscow

    Moscow, 119049
    Russian Federation

    Site Not Available

  • City Neurological Centre "SibNeyroMed", LLC

    Novosibirsk, 630091
    Russian Federation

    Site Not Available

  • Limited Liability Company Consultative Diagnostic Rheumatology Center "Healthy Joints"

    Novosibirsk, 630099
    Russian Federation

    Site Not Available

  • State Budget Educational Institution of Highest Professional Education

    Tomsk, 634050
    Russian Federation

    Site Not Available

  • State Institution of Healthcare of Yaroslavl Region

    Yaroslavl, 150003
    Russian Federation

    Site Not Available

  • ROMJAN s.r.o., Reumatologicka ambulancia

    Bratislava, Slovak Republic 83263
    Slovakia

    Site Not Available

  • MEDMAN s.r.o. - reumatologicka ambulancia

    Martin, 036 01
    Slovakia

    Site Not Available

  • Hospital Clinico de Santiago

    Santiago De Compostela, A Coruna 15706
    Spain

    Site Not Available

  • Corporacio Sanitaria Parc Tauli

    Sabadell, Barcelona 08208
    Spain

    Site Not Available

  • Hospital Universitario Marques de Valdecilla

    Santander, Cantabria 39008
    Spain

    Site Not Available

  • Hospital Sierrallana

    Torrelavega, Cantabria 39300
    Spain

    Site Not Available

  • Complejo Hospitalario Universitario A Coruna

    A Coruña, Galicia 15006
    Spain

    Site Not Available

  • Complejo Hospitalario Universitario A Coruna

    A Coruna, 15006
    Spain

    Site Not Available

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035
    Spain

    Site Not Available

  • Hospital Universitario Virgen Macarena

    Sevilla, 41009
    Spain

    Site Not Available

  • Hospital Universitaro Y Politecnico La Fe

    Valencia, 46026
    Spain

    Site Not Available

  • Buddhist Dalin Tzu Chi General Hospital

    Dalin Town, Chia-Yi 62247
    Taiwan

    Site Not Available

  • Taipei Veterans General Hospital

    Taipei, Taiwan Roc 11217
    Taiwan

    Site Not Available

  • Buddhist Dalin Tzu Chi General Hospital

    Chia-Yi, 62247
    Taiwan

    Site Not Available

  • Chang Gung Medical Foundation-Kaohsiung Branch

    Kaohsiung, 83301
    Taiwan

    Site Not Available

  • Chang Gung Medical Foundation-Kaohsiung Branch

    Kaohsiung City, 83301
    Taiwan

    Site Not Available

  • China Medical University Hospital

    Taichung, 40447
    Taiwan

    Site Not Available

  • Chung Shan Medical University Hospital

    Taichung, 40201
    Taiwan

    Site Not Available

  • Barking Havering and Redbridge University Hospitals NHS Trust

    Goodmayes, Essex IG3 8YB
    United Kingdom

    Site Not Available

  • Barking, Havering and Redbridge University Hospitals NHS Trust

    Romford, Essex RM7 0AG
    United Kingdom

    Site Not Available

  • Salford Royal

    Salford, Manchester M6 8HD
    United Kingdom

    Site Not Available

  • West Suffolk Hospital - West Suffolk Hospitals NHS Trust

    Bury St Edmunds, Suffolk IP33 2QZ
    United Kingdom

    Site Not Available

  • West Suffolk NHS Foundation Trust

    Bury St. Edmunds, Suffolk IP33 2QZ
    United Kingdom

    Site Not Available

  • West Suffolk Hospitals NHS Foundation Trust

    Bury St.Edmunds, Suffolk IP33 2QZ
    United Kingdom

    Site Not Available

  • Cardiff & Vale University Health Board

    Cardiff, Wales CF14 4XW
    United Kingdom

    Site Not Available

  • The Dudley Group NHS Foundation Trust

    Dudley, West Midlands DY1 2HQ
    United Kingdom

    Site Not Available

  • Bradford Royal Infirmary, BTHFT

    Bradford, West Yorkeshire BD9 6RJ
    United Kingdom

    Site Not Available

  • Royal United Hospitals NHS Foundation Trust

    Bath, BA1 1RL
    United Kingdom

    Site Not Available

  • Bradford Teaching Hospitals NHS Foundation Trust

    Bradford, BD5 0NA
    United Kingdom

    Site Not Available

  • Guy's & St Thomas' NHS Foundation Trust

    London, SE1 9RT
    United Kingdom

    Site Not Available

  • Queen's Medical Centre

    Nottingham, NG7 2UH
    United Kingdom

    Site Not Available

  • York Hospital, York Teaching Hospital NHS Foundation Trust

    York, YO31 8HE
    United Kingdom

    Site Not Available

  • Rheumatology Associates P.C.

    Birmingham, Alabama 35205
    United States

    Site Not Available

  • Rheumatology Associates of North Alabama, PC

    Huntsville, Alabama 35801-4414
    United States

    Site Not Available

  • Arizona Arthritis & Rheumatology Associates, P.C.

    Glendale, Arizona 85306
    United States

    Site Not Available

  • Arizona Arthritis & Rheumatology Associates, PC

    Mesa, Arizona 85202
    United States

    Site Not Available

  • Medvin Clinical Research

    Covina, California 91723
    United States

    Site Not Available

  • St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare

    Fullerton, California 92835
    United States

    Site Not Available

  • Ronald Reagan UCLA Medical Center, Drug Information Center

    Los Angeles, California 90095
    United States

    Site Not Available

  • UCLA David Geffen School of Medicine

    Los Angeles, California 90095
    United States

    Site Not Available

  • San Diego Arthritis Medical Clinic

    San Diego, California 92108
    United States

    Site Not Available

  • Stanford Hospital and Clinics

    Stanford, California 94305
    United States

    Site Not Available

  • New England Research Associates, LLC

    Trumbull, Connecticut 06611
    United States

    Site Not Available

  • Rheumatology Associates of Central Florida, PA

    Orlando, Florida 32806
    United States

    Site Not Available

  • Millennium Research

    Ormond Beach, Florida 32174
    United States

    Site Not Available

  • Arthritis Center, Inc.

    Palm Harbor, Florida 34684
    United States

    Site Not Available

  • Integral Rheumatology & Immunology Specialists (IRIS)

    Plantation, Florida 33324
    United States

    Site Not Available

  • Southwest Florida Clinical Research Center

    Tampa, Florida 33609
    United States

    Site Not Available

  • Florida Medical Clinic, P.A.

    Zephyrhills, Florida 33542
    United States

    Site Not Available

  • Arthritis and Rheumatology of GA, P.C.

    Atlanta, Georgia 30342
    United States

    Site Not Available

  • Office of Jefrey D. Lieberman, MD, P.C.

    Decatur, Georgia 30033
    United States

    Site Not Available

  • Marietta Rheumatology Associates

    Marietta, Georgia 30060
    United States

    Site Not Available

  • St. Luke's Clinic - Rheumatology

    Boise, Idaho 83702
    United States

    Site Not Available

  • St. Luke's Intermountain Research Center

    Boise, Idaho 83702
    United States

    Site Not Available

  • Professional Research Network Of Kansas, LLC

    Wichita, Kansas 67203
    United States

    Site Not Available

  • Bluegrass Community Research, Inc

    Lexington, Kentucky 40504
    United States

    Site Not Available

  • Johns Hopkins University - Division of Rheumatology

    Baltimore, Maryland 21224
    United States

    Site Not Available

  • Klein & Associates, M.D., P.A.

    Hagerstown, Maryland 21740
    United States

    Site Not Available

  • The Center for Rheumatology and Bone Research

    West Wheaton, Maryland 20902
    United States

    Site Not Available

  • The Center For Rheumatology And Bone Research

    Wheaton, Maryland 20902
    United States

    Site Not Available

  • Brigham & Women's Hospital

    Boston, Massachusetts 02115
    United States

    Site Not Available

  • Brigham and Women's Hospital

    Boston, Massachusetts 02115
    United States

    Site Not Available

  • Clinical Pharmacology Study Group

    Worcester, Massachusetts 01605
    United States

    Site Not Available

  • Bronson Internal Medicine & Rheumatology

    Battle Creek, Michigan 49015
    United States

    Site Not Available

  • St. Paul Rheumatology, PA

    Eagan, Minnesota 55121
    United States

    Site Not Available

  • Clayton Medical Research

    Saint Louis, Missouri 63117
    United States

    Site Not Available

  • Physician Research Collaboration, LLC

    Lincoln, Nebraska 68516
    United States

    Site Not Available

  • Dartmouth-Hitchcock Medical Center (DHMC)

    Lebanon, New Hampshire 03756
    United States

    Site Not Available

  • Carolina Arthritis Associates PA

    Wilmington, North Carolina 28401
    United States

    Site Not Available

  • Cincinnati Rheumatic Disease Study Group, Inc.

    Cincinnati, Ohio 45219
    United States

    Site Not Available

  • University Hospitals Case Medical Center

    Cleveland, Ohio 44106
    United States

    Site Not Available

  • Paramount Medical Research & Consulting, LLC

    Middleburg Heights, Ohio 44130
    United States

    Site Not Available

  • East Penn Rheumatology Associates, PC

    Bethlehem, Pennsylvania 18015
    United States

    Site Not Available

  • Altoona Center for Clinical Research

    Duncansville, Pennsylvania 16635
    United States

    Site Not Available

  • Clinical Research Center of Reading, LLP

    Wyomissing, Pennsylvania 19610
    United States

    Site Not Available

  • Low Country Rheumatology, PA

    Charleston, South Carolina 29406
    United States

    Site Not Available

  • Arthritis Clinic

    Jackson, Tennessee 38305
    United States

    Site Not Available

  • West Tennessee Research Institute

    Jackson, Tennessee 38305
    United States

    Site Not Available

  • Adriana M. Pop-Moody, M.D., Clinic, P.A.

    Corpus Christi, Texas 78404
    United States

    Site Not Available

  • Pioneer Research Solutions, Inc.

    Cypress, Texas 77429
    United States

    Site Not Available

  • Metroplex Clinical Research Center

    Dallas, Texas 75231
    United States

    Site Not Available

  • Pioneer Research Solutions, Inc

    Houston, Texas 77099
    United States

    Site Not Available

  • Drug Shipment/Storage: Investigational Drug Services

    Salt Lake City, Utah 84112
    United States

    Site Not Available

  • University of Utah Hospital & Clinics

    Salt Lake City, Utah 84132
    United States

    Site Not Available

  • Dynacare Laboratories

    Seattle, Washington 98122
    United States

    Site Not Available

  • Seattle Rheumatology Associates

    Seattle, Washington 98122
    United States

    Site Not Available

  • Swedish Medical Center

    Seattle, Washington 98122
    United States

    Site Not Available

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