Effects of N-acetyl Cysteine During Primary Percutaneous Coronary Intervention

Last updated: May 17, 2025
Sponsor: Suleyman Demirel University
Overall Status: Active - Not Recruiting

Phase

3

Condition

Cardiac Disease

Blood Clots

Myocardial Ischemia

Treatment

NAC

Saline

Clinical Study ID

NCT01878344
ozaydin290
  • Ages 18-85
  • All Genders

Study Summary

The aim of this study is to evaluate the effects of N-acetyl cysteine on major cardiac and cerebral events in patients undergoing primary percutaneous coronary intervention who have moderate to high risk for contrast induced nephropathy.

In a sub-group of patients coronary flow reserve will be evaluated.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients with Acute ST Elevation Myocardial Infarction undergoing PrimaryPercutaneous Coronary intervention Who Have Moderate to High Risk For ContrastInduced Nephropathy (Mehran Score ≥5)

Exclusion

Exclusion Criteria:

  • Patients >18 years old with moderate to high risk for contrast induced nephropathyundergoing percutaneous coronary intervention

  • Low risk for contrast induced nephropathy (Mehran Score <5)

  • Use of nephrotoxic agents (NSAIDs, aminoglycosides,recent contrast injection...)

  • Infection

  • Pregnancy, Lactation

  • Renal failure requiring dialysis

  • Hepatic failure

  • Allergy to NAC

  • History of Asthma

  • Chronic nitrate usage

  • Malignancy

  • Use of corticosteroids

  • Leucocytosis,Thrombocytosis,Anemia

  • Blood pressure of >180/100mmHg despite anti-hypertensive therapy

Study Design

Total Participants: 100
Treatment Group(s): 2
Primary Treatment: NAC
Phase: 3
Study Start date:
January 01, 2013
Estimated Completion Date:
December 31, 2026

Connect with a study center

  • Suleyman Demirel University

    Isparta, Mediterranean Region 32260
    Turkey

    Site Not Available

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