Olaparib Treatment in BRCA Mutated Ovarian Cancer Patients After Complete or Partial Response to Platinum Chemotherapy

Inclusion Criteria:

• Patients must be ≥ 18 years of age.

• Female patients with histologically diagnosed relapsed high grade serousovarian cancer (including primary peritoneal and / or fallopian tube cancer) orhigh grade endometrioid cancer.

• Documented mutation in BRCA1 or BRCA2 that is predicted to be deleterious orsuspected deleterious (known or predicted to be detrimental/lead to loss offunction).

• Patients who have received at least 2 previous lines of platinum containingtherapy prior to randomisation

For the penultimate chemotherapy course prior to enrolment on the study:

• Patient defined as platinum sensitive after this treatment; defined as disease progression greater than 6 months after completion of their last dose of platinum chemotherapy

For the last chemotherapy course immediately prior to randomisation on the study:

• Patients must be, in the opinion of the investigator, in response (partial orcomplete radiological response), or may have no evidence of disease (if optimalcytoreductive surgery was conducted prior to chemotherapy), and no evidence of arising CA-125, following completion of this chemotherapy course

• Patient must have received a platinum based chemotherapy regimen (e.g. carboplatinor cisplatin) and have received at least 4 cycles of treatment

• Patients must be randomized within 8 weeks of their last dose of chemotherapy

• Maintenance treatment is allowed at the end of the penultimate platinum regimen,including bevacizumab

Exclusion Criteria:

• Involvement in the planning and/or conduct of the study (applies to both AstraZenecastaff and/or staff at the study site).

• BRCA 1 and/or BRCA2 mutations that are considered to be non detrimental (e.g., "Variants of uncertain clinical significance" or "Variant of unknown significance"or "Variant, favor polymorphism" or "benign polymorphism" etc.)

• Patients who have had drainage of their ascites during the final 2 cycles of theirlast chemotherapy regimen prior to enrolment on the study.