Efficacy and Safety of PT003, PT005, and PT001 in Subjects With Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD); (PINNACLE 1)

Key Inclusion Criteria:

• Male or female subjects at least 40 years of age and no older than 80 at Visit 1.

• Subjects with an established clinical history of COPD as defined by the AmericanThoracic Society (ATS)/European Respiratory Society (ERS)

• Current or former smokers with a history of at least 10 pack-years of cigarettesmoking.

• Average f the -60 and the -30 min pre-dose FEV1 assessments must be < 80% predictednormal value calculated using National Health and Nutrition Examination Survey (NHANES) III reference equations.

• Subjects willing and, in the opinion of the investigator, able to adjust current COPDtherapy as required by the protocol

Key Exclusion Criteria:

• Significant diseases other than COPD, i.e. disease or condition which, in the opinionof the investigator, may put the patient at risk because of participation in the studyor may influence either the results of the study or the subject's ability toparticipate in the study

• Current diagnosis of asthma or alpha-1 antitrypsin deficiency

• Other active pulmonary disease such as active tuberculosis, lung cancer,bronchiectasis, sarcoidosis, idiopathic interstitial pulmonary fibrosis, primarypulmonary hypertension, or uncontrolled sleep apnea

• Hospitalized due to poorly controlled COPD within 3 months prior to screening orduring the Screening Period

• Poorly controlled COPD, defined as acute worsening of COPD that requires treatmentwith oral corticosteroids or antibiotics within 6 weeks prior to screening or duringthe Screening Period

• Lower respiratory tract infections that required antibiotics within 6 weeks prior toscreening or during the Screening Period

• Unstable ischemic heart disease, left ventricular failure, or documented myocardialinfarction within 12 months of enrollment.

• Recent history of acute coronary syndrome, percutaneous coronary intervention,coronary artery bypass graft within the past three months

• Congestive heart failure (CHF) New York Heart Association (NYHA) Class III/IV)

• Clinically significant abnormal 12-lead ECG

• Abnormal liver function tests defined as aspartate transaminase (AST), alaninetransaminase (ALT), or total bilirubin ≥ 1.5 times upper limit of normal at Visit 1and on repeat testing

• Cancer not in complete remission for at least five years

• History of hypersensitivity to β2-agonists, glycopyrronium or other muscarinicanticholinergics, lactose/milk protein or any component of the MDI Other protocol-defined inclusion/exclusion criteria may apply