Bedtime Administration of Amlodipine Versus Lisinopril

Last updated: April 18, 2013
Sponsor: Allina Health System
Overall Status: Trial Status Unknown

Phase

N/A

Condition

Stress

Williams Syndrome

Circulation Disorders

Treatment

N/A

Clinical Study ID

NCT01835418
9529148100
  • Ages 40-75
  • All Genders

Study Summary

This study seeks to compare the differences in effectiveness among individual patients treated at for hypertension with bedtime administration of amlodipine versus lisinopril. There will be an analysis of whether one medication was more effective than another and whether specific patient factors could predict who responded better to which one.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 40 to 80

  • Newly diagnosed hypertension based on 24 hour ambulatory blood pressure monitorcriteria.

  • Minimum Asleep SBP mean of ≥ 120mmHg for inclusion.

Exclusion

Exclusion Criteria:

  • Current antihypertensive medication use

  • Baseline GFR < 45

  • Preexisting macroproteinuria

  • Chronic congestive heart failure

  • History of CVA

  • Diabetes Mellitus

  • Pregnancy

  • Night-shift work

  • Other preexisting contraindication to amlodipine or lisinopril

Study Design

Total Participants: 100
Study Start date:
April 01, 2013
Estimated Completion Date: