Outcome of Acquired Haemophilia With Steroid Combined With Cyclophosphamide Versus Steroid Combined With Rituximab (CREHA Study)

Inclusion Criteria:

• men or women

• women post-menpausal or with ongoing contraception

• 18 years old or more

• diagnosis of acquired hemophilia

• patient must be insured

• patient has provided written informed consent prior to enrolment

• patient compliant

Exclusion Criteria:

• constitutional hemophilia

• chemotherapy

• ongoing treatment with prednisone > 20mg further more 1 month

• ongoing treatment with prednisone >0.7 mg/d further more 10 days

• thrombocytopenia

• leukopenia

• chronic disease