Clinical Pathway for Alzheimer's Disease in China (CPAD)

Last updated: July 22, 2017
Sponsor: Peking University
Overall Status: Completed

Phase

N/A

Condition

Memory Loss

Dementia

Alzheimer's Disease

Treatment

N/A

Clinical Study ID

NCT01779310
CENA731DCN01T
  • Ages > 45
  • All Genders

Study Summary

There are guidelines on the management of AD in China, the evidence adopted in the guidelines are mostly from the trials conducted in other countries due to very limited Chinese data available for local systematic review. Therefore, more local evidence on dementia care is needed for the development of an evidence-based guideline appropriate for people living in China. Meanwhile, the inadequate implementation of the current AD guideline, which results in the low diagnostic rate and high diagnostic leakage, may bring about extra barriers for AD patients to access dementia care service in different areas nationwide. However, there is no data on the clinical pathway about how physicians follow the dementia guideline in the routine practice.

Therefore, research is needed to learn clinical diagnostic process and treatment patterns of physicians to people with AD in routine practice and help address the low accurate rate of AD clinical diagnosis and low anti-dementia drug prescription in the real world and support guideline development.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Male and female outpatients with clinically significant cognitive impairment perindependent judgment of participating physicians;

  • Aged 45 year old and above;

  • Willing to receive 2 follow-up visits;

  • Having at least one informant or caregiver accompanying during each visit;

  • Willing to join the study and sign the informed consent prior to the study.

Exclusion

Exclusion Criteria:

  • Cognitive impairment is likely or identified as secondary to other diseasecondition(s) than AD (including but not limited to stroke, Parkinson's disease, braintrauma, central nervous system infection, etc.)

  • Unwilling to participate in the study;

  • Participating other studies during the registry study period.

Study Design

Total Participants: 1024
Study Start date:
November 01, 2012
Estimated Completion Date:
April 30, 2013

Study Description

Outpatients who are visiting memory clinics and who are judged by physicians with clinically significant cognitive impairment will be invited to join the study during the study recruiting period (with informed consent signed).

  • Patients enrolled into the study will be evaluated and diagnosed by participating physicians and may or may not be prescribed with therapy (pharmaceutical and/or non-pharmaceutical) based on physicians' medical judgment.

  • For patients with routine clinical follow-up visits, their medical charts will be reviewed for documentation. The procedures of making diagnosis and developing treatment scheme will be retrieved and documented in clinical report form (CRF). Additional procedures ordered by the participating physician at current visits will also be documented in CRF.

All participants will be followed twice after baseline visit to re-evaluate and confirm the initial diagnosis (where applicable), and to record compliance to treatment scheme, including the process of medication titration.

This study does not recommend nor restrict any specific treatments.

Connect with a study center

  • The First Affiliated Hospital of Anhui Medical University

    Hefei, Anhui
    China

    Site Not Available

  • Beijing Anzhen Hospital, Capital Medical University

    Beijing, Beijing
    China

    Site Not Available

  • Beijing Shijitan Hospital

    Beijing, Beijing
    China

    Site Not Available

  • Chinese PLA General Hospital

    Beijing, Beijing
    China

    Site Not Available

  • Peking University First Hospital

    Beijing, Beijing
    China

    Site Not Available

  • Peking University People's Hospital

    Beijing, Beijing
    China

    Site Not Available

  • Peking University Sixth Hospital

    Beijing, Beijing
    China

    Site Not Available

  • Peking University Third Hospital

    Beijing, Beijing
    China

    Site Not Available

  • Guangzhou Brain Hospital

    Guangzhou, Guangdong
    China

    Site Not Available

  • The Second Affiliated Hospital of Guangzhou Medical University

    Guangzhou, Guangdong
    China

    Site Not Available

  • The First Hospital of Hebei Medical University

    Shijiazhuang, Hebei
    China

    Site Not Available

  • Union Hospital Tongji Mecial College, Huazhong University of Science and Technology

    Wuhan, Hebei
    China

    Site Not Available

  • Nanjing Brain Hospital

    Nanjing, Jiangsu
    China

    Site Not Available

  • The Second Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi
    China

    Site Not Available

  • First Affiliated Hospital of Medical College of Xi'an Jiaotong University

    Xi'an, Shaanxi
    China

    Site Not Available

  • Shandong Mental Health Center

    Jinan, Shandong
    China

    Site Not Available

  • Shandong Provincial Hospital

    Jinan, Shandong
    China

    Site Not Available

  • Huadong Hospital Affiliated to Fudan University

    Shanghai, Shanghai
    China

    Site Not Available

  • Shanghai Changzheng Hospital

    Shanghai, Shanghai
    China

    Site Not Available

  • Shanghai Mental Health Center

    Shanghai, Shanghai
    China

    Site Not Available

  • Mental Health Center, West China Hospital, Sichuan University

    Chengdu, Sichuan
    China

    Site Not Available

  • General Hospital, Tianjin Medical University

    Tianjin, Tianjin
    China

    Site Not Available

  • Tianjin Huanhu Hospital

    Tianjin, Tianjin
    China

    Site Not Available

  • The First Teaching Hospital of Xinjiang Medical University

    Ürümqi, Xinjiang
    China

    Site Not Available

  • Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University

    Hangzhou, Zhejiang
    China

    Site Not Available

  • The First Affiliated Hospital of Zhejiang University

    Hangzhou, Zhejiang
    China

    Site Not Available

  • Ningbo Kangning Hospital

    Ningbo, Zhejiang
    China

    Site Not Available

  • The First Affiliated Hospital, Wenzhou Medical College

    Wenzhou, Zhejiang
    China

    Site Not Available

  • The First Affiliated Hospital of Chongqing Medical University

    Chongqing,
    China

    Site Not Available

  • The First Teaching Hospital of Xinjiang Medical University

    Wulumuqi,
    China

    Site Not Available

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