Danazol Treatment in Endometriosis Women Before IVF

Last updated: April 25, 2016
Sponsor: Centre for Endocrinology and Reproductive Medicine, Italy
Overall Status: Completed

Phase

4

Condition

Endometriosis

Dysfunctional Uterine Bleeding

Infertility

Treatment

N/A

Clinical Study ID

NCT01779232
CR-09-2013
  • Ages 18-40
  • Female

Study Summary

The purpose of this study is to determine whether pre-treatment with danazol for at least 4 months before controlled ovarian hyperstimulation for IVF cycles improves pregnancy rate.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Clinical diagnosis of endometriosis previous laparoscopic surgery for ovarianendometriotic cysts infertility

Exclusion

Exclusion Criteria:

  • age more than 40 years systemic disease antimulleran hormone (AMH)<1 and FSH>20

Study Design

Total Participants: 150
Study Start date:
October 01, 2012
Estimated Completion Date:
September 30, 2015

Study Description

Endometriosis is a chronic benign disease defined by the presence of endometrial tissue outside the uterine cavity, affecting women in their reproductive age. This disease is clinically characterized by infertility pelvic pain and the presence of ovarian cysts, endometriomas, and affects the about 10% of women. Women with endometriosis when undergo IVF show lower pregnancy rate than general population, and a reduced ovarian reserve, due to the diseases and often to ovarian surgery. The aim of this study is to evaluate if a pre-treatment with danazol, an anti-estrogenic agent, may improve the otcome of IVF cycles in these women

Connect with a study center

  • CERM

    Rome, 00153
    Italy

    Site Not Available

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