A Clinical Study of Xin'an Medicine in the Treatment of Bi Syndrome

Inclusion Criteria:

• Diagnosis of RA, classified by American Rheumatism Association 1987 revised criteria.

• According with the Zheng diagnosis of Traditional Chinese Medicine.

• age from 18 to 65 years.

• For patients currently receiving non-steroidal anti-inflammatory drugs (NSAIDs):Treatment at a stable dose during last 4 weeks prior to screening，or Patients do nottake NSAIDs at least 1 weeks prior to screening.

• Patients not taking DMARDs at least 4 weeks prior to screening.

• Patients taking corticosteroids (≤15mg prednisone or Equivalent) ≥4 weeks beforeentering the trial.

• Patients agree to participate in this study and sign the informed consent form.

Exclusion Criteria:

• Patients have received intra-articular or systemic corticosteroid injection within 4weeks of screening.

• Patients have high disease activity (DAS28-3 scores> 5.1).

• Patients have diagnosed any other chronic inflammatory disease or connective tissuedisease like sicca syndrome（SS）, systemic lupus erythematosus (SLE)etc;

• Patients with sever diseases in Cardiovascular, brain, lung, liver, kidney andhematopoietic system ;

• Patients who are pregnant or nursing mothers or Psychiatric patients.

• Patients with active gastroduodenal ulcer or gastritis which caused by long-term useof NSAIDs;

• The patient who has known hypersensitivity to trial medicine .

• Patients have participated in other clinical trials within 4 weeks of screening.