The Role of Myocardial Fibrosis in Patients With Aortic Stenosis

Phase

N/A

Condition

Heart Defect

Congestive Heart Failure

Scar Tissue

Treatment

N/A

Clinical Study ID

NCT01755936

2010/R/CAR/05

Ages > 18
All Genders
Accepts Healthy Volunteers

Study Summary

Aortic stenosis is the most common adult valvular heart disease in the western world. Heart failure and sudden cardiac death are complications associated with aortic stenosis. In symptomatic individuals, valve replacement is often the only effective treatment. However, there are no good markers to identify patients who may benefit from early surgery before symptoms developed. The purpose of the study is to test the hypothesis that the presence heart muscle scarring on the cardiac magnetic resonance imaging may predict a worse outcome in patients with aortic stenosis, and thus may be helpful in identifying patients for early valve replacement.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Patients with aortic stenosis
Willing to undergo all investigations

Exclusion

Exclusion Criteria:

Coexisting mitral valvular heart disease and aortic regurgitation (more than moderateseverity)
Active medical conditions: ongoing heart failure, infection
Significant comorbidities: advanced malignancy with limited life expectancy
Unable to give informed consent
Contraindication for cardiac magnetic resonance imaging: impaired renal function,pacemaker, claustrophobia

Study Design

January 01, 2012

August 31, 2017

Study Description

Congestive heart failure and sudden cardiac death are associated complications of aortic stenosis. Currently, the indications for valvular replacement are based on the valvular severity evaluated by echocardiography and the presence of symptoms. There is some evidence to suggest the presence of myocardial fibrosis is associated with a poor outcome in patients with aortic stenosis. The aim of this prospective study is to investigate the prognostic implications of myocardial fibrosis in patients with aortic stenosis. The presence of myocardial fibrosis will be identified by delayed enhancement with the cardiac magnetic resonance imaging at 3T. We will also be evaluating the application of T1 mapping techniques to detect diffuse myocardial fibrosis.

Connect with a study center

University of Edinburgh
Edinburgh, Midlothian EH16 4SB
United Kingdom
Site Not Available

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