Epidemiology of Inflammatory Bowel Disease in the Songpa-Kangdong District, Seoul, Korea.

Last updated: January 11, 2021
Sponsor: Asan Medical Center
Overall Status: Active - Recruiting

Phase

N/A

Condition

Ulcerative Colitis

Inflammatory Bowel Disease

Bowel Dysfunction

Treatment

N/A

Clinical Study ID

NCT01731665
2012-0634
  • All Genders

Study Summary

The purpose of this study is to evaluate the incidence, prevalence, clinical characteristics and prognosis of Crohn's disease and ulcerative colitis over time in a district of Seoul, Korea.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Definite cases of CD and UC Patients are diagnosed with CD if they meet at least 2 of the following criteria:
  1. clinical history of abdominal pain, weight loss, malaise, diarrhea, and/or rectalbleeding
  2. endoscopic findings of mucosal cobblestoning, linear ulceration, skip areas, orperianal disease
  3. radiologic findings of stricture, fistula, mucosal cobblestoning, or ulceration
  4. macroscopic appearance of bowel wall induration, mesenteric lymphadenopathy, and "creeping fat" at laparotomy
  5. pathologic findings of transmural inflammation and/or epithelioid granulomas Only patients who meet these criteria for at least 2 months are included. Patients are diagnosed with UC only if all 3 of the following criteria are present
  6. a typical history of diarrhea or blood and pus or both in the stool for longer than 4weeks
  7. a typical sigmoidoscopic or colonoscopic picture with diffusely granular, friable, orulcerated mucosa without rectal sparing or skip lesions or radiological signs ofcharacteristic continuous granular or ulcerated mucosa
  8. characteristic histopathological signs of inflammation on biopsy

Exclusion

Exclusion Criteria:

  • IBD unclassified
  • Ethnic groups other than Korean

Study Design

Total Participants: 2000
Study Start date:
December 01, 2012
Estimated Completion Date:
June 30, 2029

Study Description

Inflammatory bowel disease (IBD), which is comprised of Crohn's disease (CD) and ulcerative colitis (UC) is a chronic inflammatory disease of gut with uncertain etiopathogenesis. According to our previous study (Yang, et al. Inflamm Bowel Dis 2008; 14: 542-549), the incidence and prevalence of IBD in Korea are still low compared with those in Western countries, but are rapidly increasing. However, the long-term trends of epidemiology of CD and UC together with their characteristics and prognosis in Korea are uncertain yet. The investigators therefore aim to elucidate the incidence and prevalence of CD and UC over a 30-year period, from 1986 to 2017, in the Songpa-Kangdong district of Seoul, Korea. In addition, the investigators also aim to reveal the clinical features at the time of diagnosis of IBD, long-term evolution of disease and prognosis.

Connect with a study center

  • Asan Medical Center

    Seoul, 138-736
    Korea, Republic of

    Active - Recruiting

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