RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain

Last updated: June 10, 2026
Sponsor: Boston Scientific Corporation
Overall Status: Active - Recruiting

Phase

N/A

Condition

Chronic Pain

Pain

Treatment

neurostimulation system

Clinical Study ID

NCT01719055
A7007
90876777
  • Ages > 18
  • All Genders

Study Summary

To compile characteristics of real-world clinical outcomes for Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice, when used according to the applicable Instructions for Use

  • and -

To evaluate the economic value and technical performance of Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  • Study candidate is scheduled to be trialed, on-label, with a commercially approvedBoston Scientific neurostimulation system for pain, per local directions for use

  • Signed a valid, IRB/EC-approved informed consent form

  • 18 years of age or older

Exclusion

Key Exclusion Criteria:

  • Contraindicated for Boston Scientific neurostimulation system

  • Currently diagnosed with cognitive impairment, or exhibits any characteristic, thatwould limit study candidate's ability to assess pain relief or to complete studyassessments

Study Design

Total Participants: 4800
Treatment Group(s): 1
Primary Treatment: neurostimulation system
Phase:
Study Start date:
November 19, 2012
Estimated Completion Date:
May 31, 2035

Study Description

The study is a prospective, multi-center, global, post-market study of Boston Scientific neurostimulation systems for pain.

The study treatment will consist of neurostimulation trial therapy with any commercially approved Boston Scientific Corporation neurostimulator for pain. Positive trials, subjects with a successful trial outcome, may progress to permanent implant of a neurostimulation system. Individualization of neurostimulation therapy for pain will be determined according to investigator discretion and site routine care, and in accordance with inclusion and exclusion criteria.

Connect with a study center

  • CENIT Centro de Neurociencias, Investigacion y Tratamiento

    Buenos Aires,
    Argentina

    Terminated

  • CENIT Centro de Neurociencias, Investigacion y Tratamiento

    Ciudad Autonoma de Buenos Aires,
    Argentina

    Completed

  • Interventus Pain Specialists

    Auchenflower,
    Australia

    Site Not Available

  • Hunter Clinical Research

    Broadmeadow,
    Australia

    Terminated

  • Hunter Pain Clinic

    Broadmeadow,
    Australia

    Terminated

  • Hunter Clinical Research

    Broadmeadow 10103838,
    Australia

    Terminated

  • Green Lizard Science

    Claremont,
    Australia

    Terminated

  • Sydney Spine and Pain Pty Ltd

    Hurstville,
    Australia

    Terminated

  • Sunshine Coast Clinical Research

    Noosa,
    Australia

    Terminated

  • Sunshine Coast Clinical Research

    Noosa Heads,
    Australia

    Site Not Available

  • Pain Matrix

    Waurn Ponds,
    Australia

    Terminated

  • Pain Medicine of South Australia

    Wayville,
    Australia

    Active - Recruiting

  • AZ Sint-Lucas

    Gent,
    Belgium

    Terminated

  • AZ Sint-Lucas

    Ghent,
    Belgium

    Site Not Available

  • AZ Delta

    Roeselare,
    Belgium

    Terminated

  • London Health Sciences Centre

    London,
    Canada

    Terminated

  • Hopital de Enfant-Jesus

    Québec,
    Canada

    Active - Recruiting

  • Regina General Hospital

    Regina,
    Canada

    Active - Recruiting

  • Fundacion Clinica Valle del Lili

    Cali,
    Colombia

    Site Not Available

  • Fundacion Cardiovascular de Colombia Floridablanca

    Floridablanca,
    Colombia

    Terminated

  • Odense University Hospital

    Odense,
    Denmark

    Terminated

  • Universitatsklinik Charite Berlin

    Berlin,
    Germany

    Active - Recruiting

  • University KH Bonn

    Bonn,
    Germany

    Terminated

  • Uniklinik Köln

    Cologne,
    Germany

    Terminated

  • Uniklinik Köln

    Cologne 2886242,
    Germany

    Active - Recruiting

  • Universitaetsklinikum Dusseldorf

    Duesseldorf,
    Germany

    Active - Recruiting

  • Universitaetsklinikum Dusseldorf

    Düsseldorf,
    Germany

    Active - Recruiting

  • Uniklinik Köln

    Koeln,
    Germany

    Terminated

  • Uniklinik Köln

    Köln,
    Germany

    Active - Recruiting

  • Algesiologikum

    München,
    Germany

    Terminated

  • Sheba Medical Center

    Ramat Gan,
    Israel

    Terminated

  • Sheba Medical Center

    Ramat-Gan,
    Israel

    Completed

  • Tel Aviv Sourasky Medical Center

    Tel Aviv,
    Israel

    Terminated

  • Fondazione Salvatore Maugeri IRCCS

    Pavia,
    Italy

    Active - Recruiting

  • Azienda Ospedaliero Universitaria Pisana

    Pisa,
    Italy

    Terminated

  • Kobe University Hospital

    Kobe,
    Japan

    Terminated

  • Kobe University Hospital

    Kobe-shi,
    Japan

    Completed

  • Hyogo College of Medicine Hospital

    Nishinomiya-shi,
    Japan

    Terminated

  • Okayama University Hospital

    Okayama,
    Japan

    Terminated

  • Okayama University Hospital

    Okayama-shi,
    Japan

    Completed

  • Sakai Hospital Kinki University Faculty of Medicine

    Sakai-shi,
    Japan

    Completed

  • Sakai Hospital Kinki University Faculty of Medicine

    Sakaishi,
    Japan

    Terminated

  • Ziekenhuis Rijnstate

    Velp,
    Netherlands

    Terminated

  • Hospital General de Ciudad Real

    Ciudad Real,
    Spain

    Active - Recruiting

  • Hospital La Paz

    Madrid,
    Spain

    Terminated

  • Hospital La Princesa

    Madrid,
    Spain

    Terminated

  • Hospital Puerta de Hierro

    Madrid,
    Spain

    Active - Recruiting

  • Hospital Universitario Infanta Elena

    Madrid,
    Spain

    Site Not Available

  • Hospital La Paz

    Madrid 3117735,
    Spain

    Terminated

  • Hospital Puerta de Hierro

    Madrid 3117735,
    Spain

    Active - Recruiting

  • Hospital Universitario Infanta Elena

    Madrid 3117735,
    Spain

    Site Not Available

  • Clinica Universidad de Navarra

    Pamplona,
    Spain

    Active - Recruiting

  • Hospital Donostia

    San Sebastián,
    Spain

    Site Not Available

  • H. Marques De Valdecilla

    Santander,
    Spain

    Terminated

  • Hospital Virgen De La Salud

    Toledo,
    Spain

    Terminated

  • Hospital General de Valencia

    Valencia,
    Spain

    Active - Recruiting

  • Sahlgrenska University Hospital

    Gothenburg,
    Sweden

    Terminated

  • Sahlgrenska University Hospital

    Göteborg,
    Sweden

    Active - Recruiting

  • Ospedale Regionale di Lugano

    Viganello,
    Switzerland

    Terminated

  • Basildon and Thurrock University Hospitals NHS

    Basildon,
    United Kingdom

    Active - Recruiting

  • Southmead Hospital Bristol

    Bristol,
    United Kingdom

    Active - Recruiting

  • The General Infirmary

    Leeds,
    United Kingdom

    Active - Recruiting

  • Chelsea and Westminster Hospital

    London,
    United Kingdom

    Terminated

  • St. Bartholomews Hospital

    London,
    United Kingdom

    Active - Recruiting

  • Chelsea and Westminster Hospital

    London 2643743,
    United Kingdom

    Terminated

  • James Cook University Hospital

    Middlesbrough,
    United Kingdom

    Active - Recruiting

  • Royal National Orthopaedic Hospital

    Stanmore,
    United Kingdom

    Terminated

  • Hope Research Institute

    Phoenix, Arizona 85018
    United States

    Terminated

  • Physicians Research Group, LLC

    Phoenix, Arizona 85016
    United States

    Terminated

  • Banner University Medical Center

    Tucson, Arizona 85724
    United States

    Completed

  • Hope Research Institute

    Phoenix 5308655, Arizona 5551752 85018
    United States

    Terminated

  • Comprehensive Pain Management Center

    Campbell, California 95008
    United States

    Terminated

  • Coastal Research Institute

    Carlsbad, California 92009
    United States

    Terminated

  • Pain Medicine Associates, Inc.

    Fountain Valley, California 92708
    United States

    Terminated

  • Metropolitan Pain Management Consultants Inc.

    Sacramento, California 95821
    United States

    Terminated

  • Huntley Pain Specialists

    San Diego, California 92108
    United States

    Site Not Available

  • Conejo Pain Specialists

    Thousand Oaks, California 91362
    United States

    Terminated

  • Denver Back Pain Specialists

    Greenwood Village, Colorado 80111
    United States

    Active - Recruiting

  • Orlando Health Neuroscience Institute, Inc

    Clermont, Florida 34711
    United States

    Active - Recruiting

  • South Lake Pain Institute, Inc

    Clermont, Florida 34711
    United States

    Active - Recruiting

  • University of Florida Shands Hospital

    Gainesville, Florida 32608
    United States

    Active - Recruiting

  • Louis J. Raso, MD, PA

    Jupiter, Florida 33477
    United States

    Terminated

  • Advanced Interventional Pain Management and Research Clinic, Inc.

    Miami Gardens, Florida 33169
    United States

    Terminated

  • JM Clinical Research

    South Miami, Florida 33143
    United States

    Site Not Available

  • Tallahassee Neurological Clinic, PA

    Tallahassee, Florida 32308
    United States

    Terminated

  • South Lake Pain Institute, Inc

    Clermont 4151352, Florida 4155751 34711
    United States

    Active - Recruiting

  • Orthopedic Research Foundation

    Savannah, Georgia 31405
    United States

    Terminated

  • Pain Care, LLC

    Stockbridge, Georgia 30281
    United States

    Site Not Available

  • Chicago Anesthesia Pain Specialists

    Chicago, Illinois 60657
    United States

    Terminated

  • Northwestern Memorial Hospital - Neurosurgery Outpatient Clinic

    Chicago, Illinois 60611
    United States

    Terminated

  • Chicago Anesthesia Pain Specialists

    Chicago 4887398, Illinois 4896861 60657
    United States

    Terminated

  • Global Scientific Innovations - Advanced Pain Care Clinic

    Evansville, Indiana 47714
    United States

    Terminated

  • Summit Research Institute

    Fort Wayne, Indiana 46825
    United States

    Terminated

  • Goodman Campbell Brain and Spine

    Greenwood, Indiana 46143
    United States

    Site Not Available

  • American Health Network of Indiana, LLC

    Muncie, Indiana 47304
    United States

    Terminated

  • Research Medical Center

    Lenexa, Kansas 66214
    United States

    Terminated

  • Neuroscience Associates of Northern Kentucky

    Crestview Hills, Kentucky 41017
    United States

    Site Not Available

  • Bux Pain Management

    Danville, Kentucky 40422
    United States

    Terminated

  • Ochsner Clinic Foundation

    New Orleans, Louisiana 70115
    United States

    Active - Recruiting

  • Willis-Knighton River Cities Clinical Research Center

    Shreveport, Louisiana 71105
    United States

    Active - Recruiting

  • Brigham and Women's Hospital

    Boston, Massachusetts 02115
    United States

    Active - Recruiting

  • Beth Israel Deaconess Medical Center

    Brookline, Massachusetts 02445
    United States

    Terminated

  • Michigan Pain Specialists

    Ann Arbor, Michigan 48108
    United States

    Active - Recruiting

  • Insight Institute of Neurosurgery & Neuroscience

    Flint, Michigan 48507
    United States

    Terminated

  • Forest Health Medical Center

    Ypsilanti, Michigan 48198
    United States

    Terminated

  • Jackson Anesthesia Pain Center, LLC

    Jackson, Mississippi 39202
    United States

    Terminated

  • Midwest Pain Center

    Chesterfield, Missouri 63005
    United States

    Terminated

  • Saint Louis Pain Consultants

    Chesterfield, Missouri 63017
    United States

    Terminated

  • KC Pain Centers

    Lee's Summit, Missouri 64086
    United States

    Terminated

  • Saint Louis Pain Consultants

    Chesterfield 4381072, Missouri 4398678 63017
    United States

    Terminated

  • Hope Research Institute

    Las Vegas, Nevada 89106
    United States

    Site Not Available

  • Albany Medical Center

    Albany, New York 12208
    United States

    Terminated

  • New York Presbyterian Hospital

    New York, New York 10065
    United States

    Terminated

  • University of Rochester

    Rochester, New York 14618
    United States

    Terminated

  • Montefiore Medical Center

    The Bronx, New York 10461
    United States

    Active - Recruiting

  • Spine and Skeletal Pain Medicine

    Utica, New York 13502
    United States

    Terminated

  • Carolinas Research Institute, PLLC

    Huntersville, North Carolina 28078
    United States

    Terminated

  • Raleigh Neurology Associates, P.A.

    Raleigh, North Carolina 27607
    United States

    Terminated

  • The Center for Clinical Research, LLC

    Winston-Salem, North Carolina 27103
    United States

    Terminated

  • Case Western Reserve University

    Cleveland, Ohio 44106
    United States

    Completed

  • Ohio State University Medical Center

    Columbus, Ohio 43203
    United States

    Terminated

  • University of Toledo Medical Center

    Toledo, Ohio 43614
    United States

    Terminated

  • Pacific Sports and Spine, LLC

    Eugene, Oregon 97401
    United States

    Active - Recruiting

  • Fox Chase Pain Management

    Trevose, Pennsylvania 19053
    United States

    Active - Recruiting

  • Medical University of South Carolina

    Charleston, South Carolina 29425
    United States

    Terminated

  • Florence Neurosurgery and Spine

    Florence, South Carolina 29506
    United States

    Terminated

  • PCPMG Clinical Research Unit, LLC

    Greenville, South Carolina 29601
    United States

    Active - Recruiting

  • Channel Research

    Pawleys Island, South Carolina 29585
    United States

    Terminated

  • Balcones Pain Consultants

    Austin, Texas 78745
    United States

    Terminated

  • Institute of Precision Pain Medicine

    Corpus Christi, Texas 78414
    United States

    Active - Recruiting

  • Spine Works Institute

    North Richland Hills, Texas 76182
    United States

    Terminated

  • Spine Team Texas

    Rockwall, Texas 75032
    United States

    Terminated

  • Precision Spine Care

    Tyler, Texas 75701
    United States

    Terminated

  • Washington Center for Pain Management

    Bellevue, Washington 98004
    United States

    Terminated

  • EvergreenHealth Pain Care

    Kirkland, Washington 98034
    United States

    Site Not Available

  • Swedish Neuroscience Institute

    Seattle, Washington 98122
    United States

    Terminated

  • West Virginia University Hospitals

    Morgantown, West Virginia 26506
    United States

    Site Not Available

  • Advanced Pain Management Appleton

    Greenfield, Wisconsin 53221
    United States

    Terminated

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