An Extension Study of WA19926 of the Long-Term Safety of Tocilizumab (RoActemra/Actemra) in Patients With Early Moderate to Severe Rheumatoid Arthritis

Inclusion Criteria:

• Adult participants, >/= 18 years of age
• Participants who complete their last WA19926 core study visit (Week 104) and who maybenefit from study drug treatment according to the Investigator's assessment
• No current or recent adverse event or laboratory finding preventing the use of thestudy drug dose of RoActemra/Actemra 8 mg/kg at baseline visit
• Women of childbearing potential must agree to use adequate contraception as defined byprotocol during the treatment period

Exclusion Criteria:

• Pregnant females
• Participants who have withdrawn prematurely from the WA19926 core study for any reason
• Treatment with any investigational agent or cell-depleting therapies since the lastadministration of study drug in WA19926
• Treatment with an anti-tumor necrosis factor (TNF) or anti-interleukin (IL) 1 agent,or a T-cell costimulation modulator since the last administration of study drug inWA19926
• Immunization with a live/attenuated vaccine since the last administration of studydrug in WA19926
• Diagnosis since last WA19926 visit (Week 104) of rheumatic autoimmune disease otherthan rheumatoid arthritis
• Diagnosis since last WA19926 visit (Week 104) of inflammatory joint disease other thanrheumatoid arthritis
• History of severe allergic or anaphylactic reactions to humanized or murine monoclonalantibodies, including tocilizumab and its excipients
• Evidence of severe uncontrolled concomitant disease or disorder
• Known active or history of recurrent infections
• Active tuberculosis requiring treatment in the previous 3 years
• History of alcohol, drug or chemical abuse since inclusion in the WA19926 study