Enhanced External Counterpulsation and Its Effects on Vascular Hemodynamics in Cognitively Impaired Patients

Inclusion Criteria:

• An adult between 18 and 85 years of age.

• Has been evaluated to have a CDR (Clinical Dementia Rating) Score of 0.5

• Male or female (if female must be postmenopausal for at least 1 year, surgicallysterile or using an effective form of contraception).

• Able to speak and read English.

• Willing to comply with study specific instructions, and complete all study proceduresaccording to protocol.

• Able to understand study rationale and sign informed consent.

Exclusion Criteria:

• Diagnosed with glaucoma

• History of developing adverse effects to ophthalmic dilating agents (phenylephrine ortropicamide).

• Currently taking warfarin and dabigatran (Pradaxa).

• History of having arrhythmias - can interfere with EECP triggering.

• Subject has bleeding diathesis.

• Subject has active thrombophlebitis.

• Subject has severe lower extremity vaso-occlusive disease.

• Subject has a documented aortic aneurysm requiring surgical repair.

• Subject is pregnant.

• Subject with blood pressure higher than 180/110 mmHg.

• Subject with a heart rate more than 120 bpm.

• Subject with high risk of complications from increased venous return.

• Subject with clinically significant valvular disease.

• Subjects with severe vascular disease as established by the Hachinski Ischemic Index.

• Subjects with pacemakers and other metallic implantable devices.