The Impact of Triptan and Doxycycline on Neuroinflammatory Biomarkers in Acute Migraine

Last updated: December 27, 2016
Sponsor: The Cleveland Clinic
Overall Status: Trial Not Available

Phase

N/A

Condition

Pain

Migraine (Adult)

Chronic Pain

Treatment

N/A

Clinical Study ID

NCT01653522
12-061
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The purpose of this study is to determine the effects of triptans and doxycycline on neuroinflammatory markers in acute migraine.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Clinical diagnosis of migraine with or without aura that fulfill the 2nd Edition ofThe International Headache Classification (ICHD-II) criteria

  • Active prescription for an oral triptan medication to abort acute migraines

Exclusion

Exclusion Criteria:

  • Tetracycline group or other anti-inflammatory medication use in the preceding threemonths

  • Pregnant

Study Design

Study Start date:
July 01, 2012
Estimated Completion Date:
July 31, 2014

Study Description

Increased inflammatory cytokines and matrix metalloproteinases (MMPs) have been recently implicated in migraine. Inflammation may be a key player in the pathophysiology of migraine by altering blood-brain barrier (BBB) function. As an inflammation induced MMP, MMP-9 is involved in both BBB disruption and neuropathic pain, and is largely derived by neutrophil degranulation during neutrophil-BBB interaction. The tetracycline group of antibiotics may suppress MMP production and neutrophil degranulation. This study aims to investigate known neuroinflammatory biomarkers with a focus on BBB breakdown during acute migraine attacks and assess marker responses to conventional treatment (triptans) and novel MMP targeted therapy (doxycycline). This pilot project data will supplement future projects investigating novel therapeutic strategies such as MMP inhibitors in both migraine acute treatment and prevention.

Connect with a study center

  • Cleveland Clinic

    Cleveland, Ohio 44195
    United States

    Site Not Available

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