Phase
Condition
Enuresis
Overactive Bladder
Treatment
N/AClinical Study ID
Ages 30-100 Female Accepts Healthy Volunteers
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Postmenopausal Women defined as at least 12 months since last menstrual period
OAB symptoms for 6 months or longer with complaints of frequency (8 or more voids in a 24 hour period), and either 6 or more urgency episodes in 24 hours, and either 3 ormore urge urinary incontinence episodes per 24 hours.
Exclusion
Exclusion Criteria:
Current or recent treatment (within the last 6 months) with estrogens
Past or present history of estrogen dependent neoplasm
Undiagnosed genital tract bleeding
Current urinary or vaginal infection
History of thromboembolic disorders associated with estrogen use
Commencement or alteration of diuretic therapy within three months of study enrollment
No contraindications for anticholinergic medical therapy
No contraindications to estrogen therapy
Symptoms must not have commenced more than three years prior to menopause
Post Void Residual must be under or equal to 150 ml
Recurrent Urinary Tract Infections (3 culture proven UTI's within the past 12 months)
Not on any other anticholinergic medications for the last 4 weeks
Painful Bladder Syndrome
Chronic Pelvic Pain
Vaginal Prolapse POPQ > stage 2/ maximal prolapse point greater than +1 cm
Study Design
Study Description
Connect with a study center
Cleveland Clinic Florida
Weston, Florida 33331
United StatesActive - Recruiting
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