Study of TAK-875 in Adults With Type 2 Diabetes and Cardiovascular Disease or Risk Factors for Cardiovascular Disease

Last updated: October 15, 2015
Sponsor: Takeda
Overall Status: Terminated

Phase

3

Condition

Diabetes Mellitus, Type 2

Cardiovascular Disease

Vascular Diseases

Treatment

N/A

Clinical Study ID

NCT01609582
TAK-875_306
PHRR130916-000119
TAK-875_306CTIL
DOH-27-0313-4117
2011-001732-37
NMRR-12-433-12087
U1111-1129-7824
12/SC/0504
1015031332
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to demonstrate no excess risk of cardiovascular (CV) composite events exists following long term treatment with TAK-875 compared with placebo.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. In the opinion of the investigator, the patient is capable of understanding andcomplying with protocol requirements, including scheduled clinic appointments.

  2. The patient or, when applicable, the patient's legally acceptable representative signsand dates a written, informed consent form and any required privacy authorizationprior to the initiation of any study procedures.

  3. Has a diagnosis of type 2 diabetes mellitus.

  4. Has an glycosylated hemoglobin (HbA1c) level between 7.0% and 10.5%, inclusive, atScreening. HbA1c testing may be repeated once during Screening.

  5. Meets at least one (1) of the following three (3) High Risk Categories (a-c ):

  6. A documented history of myocardial infarction (MI) occurring no less than 2months (60 days) and no greater than 24 months prior to Screening.

  7. Documented symptomatic peripheral arterial disease (PAD) (at least one (1) of thefollowing three (3) criteria must be satisfied): i) Current intermittentclaudication together with documented ankle-brachial index ≤0.85. ii) History ofprevious vascular intervention for intermittent claudication or resting limbischemia (example: amputation for arterial disease, peripheral bypass, or historyof angioplasty/stenting). iii) History of symptomatic carotid artery disease (requiring revascularization with carotid endarterectomy (CEA) or stenting).

  8. Documented cerebrovascular disease (at least one (1) of the following two (2)criteria must be satisfied): i) A history of transient ischemic attack (TIA)confirmed by a neurologist no greater than 24 months prior to screening andclinically and neurologically stable at randomization. ii) A history of ischemicstroke (IS) (with a Modified Rankin Scale Score ≤3 documented prior toRandomization) not less than 2 months (60 days) and no greater than 24 monthsprior to Screening, and clinically and neurologically stable at Randomization.The Modified Rankin Scale is located in appendix in protocol. Or meets at least one (1) of the following five (5) Intermediate Risk Categories (d-h):

  9. Stable angina with coronary disease documented by the presence of inducibleischemia or scar by stress myocardial perfusion imaging (MPI), echocardiogram ormagnetic resonance imaging (MRI) in the past 24 months.

  10. Multi vessel coronary disease, based on coronary angiography, with or withoutangina, documented by >50% diameter stenosis in at least 2 of the 3 majorcoronary distributions.

  11. A history of percutaneous coronary intervention (PCI) or coronary artery bypassgrafting (CABG) at least 2 months prior to Screening.

  12. The subject has diabetic nephropathy plus (2) of the clinical criteria listedbelow (i. to vi.). Diabetic nephropathy is defined as either urinary albuminexcretion ≥ 30 µg/mg creatinine (3.4 mg/mmol creatinine) (based on a random spotcollection) or urinary albumin excretion ≥ 30 mg/24h (based on a 24 h or timedcollection). Results must be confirmed on at least two specimens collected within 12 months prior to Screening and no more than 6 months apart: i)Duration ofdiabetes ≥ 10 years on pharmacological treatment documented within medicalrecords. ii) Confirmed systolic blood pressure (SBP) ≥150 mm Hg on 2 separatedays during Screening despite treatment with at least 2 anti-hypertensivemedications administered at doses considered optimal by local standard of care.iii) Presence of dyslipidemia as defined by any one (1) of the followingconfirmed at screening: A. Low density lipoprotein (LDL) > 100 mg/dl (2.59mmol/L) while on statin therapy administered at maximum tolerated dose or optimaldose based on local standard of care for at least 4 weeks prior to screening. B.LDL > 130 mg/dL (3.37 mmol/L) when not on statin therapy. C. High densitylipoprotein (HDL) < 40 mg/dL (1.04 mmol/L) in males or < 45 mg/dL (1.17 mmol/L)in females. D. Fasting Triglyceride >200 mg/dL(2.26 mmol/L). iv) Currentlysmoking >10 cigarettes per day at Screening. v) Male ≥65 years of age or female ≥70 years of age. vi) Highly selective C-reactive protein (hs-CRP) > 2.0 mg/L inthe absence of intercurrent infection or acute process. h.) The subject meets at least five (5) of the following clinical criteria: i.)Duration of diabetes ≥10 years on pharmacological treatment documented within medicalrecords. ii) Confirmed systolic blood pressure (SBP) ≥150 mm Hg on 2 separate daysduring Screening despite treatment with at least 2 anti-hypertensive medicationsadministered at doses considered optimal by local standard of care. iii) Presence ofdyslipidemia as defined by any one (1) of the following confirmed at screening: A. Lowdensity lipoprotein (LDL) > 100 mg/dl (2.59 mmol/L) while on statin therapyadministered at maximum tolerated dose or optimal dose based on local standard of carefor at least 4 weeks prior to screening. B. LDL > 130 mg/dL (3.37 mmol/L) when not onstatin therapy. C. High density lipoprotein (HDL) < 40 mg/dL (1.04 mmol/L) in males or < 45 mg/dL (1.17 mmol/L) in females. D. Fasting Triglyceride >200 mg/dL(2.26 mmol/L).iv) Currently smoking >10 cigarettes per day at Screening. v) Male ≥65 years of age orfemale ≥70 years of age. vi) Highly selective C-reactive protein (hs-CRP) > 2.0 mg/Lin the absence of intercurrent infection or acute process.

  13. Is able and willing to monitor glucose with a home glucose monitor and consistentlyrecord his or her own blood glucose concentrations in patient diaries.

  14. A female of childbearing potential who is sexually active with a non-sterilized malepartner agrees to routinely use adequate contraception from signing of informedconsent throughout the duration of the study and for 30 days after the last dose ofstudy drug.

  15. Subjects with alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≤3xupper limit of normal (ULN) and if ALT or AST elevated above ULN, have chronic,well-compensated liver disease documented by usual clinical parameters.

Exclusion

Exclusion Criteria:

  1. Has received any investigational medication within 30 days prior to Screening or anyinvestigational antidiabetic medication or excluded medications within 3 months priorto Screening.

  2. Has been randomized into a previous TAK-875 study.

  3. Is an immediate family member, study site employee, or is in a dependant relationshipwith a study site employee who is involved in conduct of this study (eg, spouse,parent, biological or legally adopted child, or sibling) or may consent under duress

  4. Is diagnosed with type 1 diabetes mellitus or latent autoimmune diabetes in adults.

  5. Is hemodynamically unstable, including severe heart failure (New York HeartAssociation Class IV) at Screening.

  6. Is hospitalized at the Screening Visit for the event associated with the CV inclusioncriteria. (Patients who have been discharged from an acute hospital to a cardiacrehabilitation center or nursing home at the time of the Screening Visit orRandomization Visit are not excluded).

  7. Has ALT and/or AST levels >3.0x ULN at Screening.

  8. Has a total bilirubin level >ULN at Screening. Exception: if a patient has documentedGilbert's Syndrome, the patient will be allowed with an elevated bilirubin level perthe investigator's discretion.

  9. Has an glomerular filtration rate (estimated) (eGFR) ≤ 15 mL/min/1.73m2 based onModification of Diet in Renal Disease (MDRD) calculation at Screening and is currentlyon dialysis or expected to start dialysis within the next 6 months.

  10. Has uncontrolled thyroid disease, as determined by the investigator and/or clinicalinvestigation.

  11. Has a known history of infection with human immunodeficiency virus (HIV).

  12. Has a known active infection with Hepatitis B virus (HBV), or Hepatitis C virus (HCV)requiring antiviral treatment.

  13. Has a history of drug abuse (defined as illicit drug use) or a history of alcoholabuse within 2 years prior to Screening.

  14. Has any major illness or condition that, in the investigator's opinion, prohibits thepatient from participating in the study or meeting the planned visit schedule.

  15. Has a history of hypersensitivity, allergies, or has had an anaphylactic reaction(s)to TAK-875.

  16. If female, is pregnant (confirmed by laboratory testing, ie, serum or urine humanchorionic gonadotropin (hCG), in females of childbearing potential) or lactating orintending to become pregnant before, during, or within 30 days after participating inthis study; or intending to donate ova during such time period.

  17. Is unable to understand verbal or written English or any other language for which acertified translation of the approved informed consent is available.

  18. Has a history of cancer that has been in remission for <5 years prior to Screening. Ahistory of basal cell carcinoma or Stage 1 squamous cell carcinoma of the skin isallowed.

Study Design

Total Participants: 3207
Study Start date:
June 01, 2012
Estimated Completion Date:
May 31, 2014

Study Description

The drug being tested in this study is called TAK-875. TAK-875 is being tested to treat people who have diabetes. This study will look at the number of cardiovascular events (for example, heart attacks) of people who take TAK-875 in comparison to placebo in addition to standard care.

The study will enroll approximately 5000 patients. Participants will be randomly assigned (by chance, like flipping a coin) to one of the two treatment groups—which will remain undisclosed to the patient and study doctor during the study (unless there is an urgent medical need):

  • TAK-875 50 mg.

  • Placebo (dummy inactive pill) - this is a tablet that looks like the study drug but has no active ingredient.

All participants will be asked to take one tablet at the same time each day throughout the study. All participants will be asked to record any time they have low blood sugar symptoms in a diary.

This multi-centre trial will be conducted worldwide, in approximately 700 sites. The overall time to participate in this study is 6 years. Participants will make up to approximately 24 visits to the clinic, with telephone visits conducted on an alternate 6 month schedule starting from Month 27.

Due to potential concerns about liver safety, on balance, the benefits of treating patients with fasiglifam (TAK-875) do not outweigh the potential risks.

For this reason, Takeda has decided voluntarily to terminate the development activities for fasiglifam.

Connect with a study center

  • Bahia Blanca, Buenos Aires
    Argentina

    Site Not Available

  • Haedo, Buenos Aires
    Argentina

    Site Not Available

  • La Plata, Buenos Aires
    Argentina

    Site Not Available

  • Loma Hermosa, Buenos Aires
    Argentina

    Site Not Available

  • Mar del Plata, Buenos Aires
    Argentina

    Site Not Available

  • Quilmes, Buenos Aires
    Argentina

    Site Not Available

  • San Nicolas, Buenos Aires
    Argentina

    Site Not Available

  • Zarate, Buenos Aires
    Argentina

    Site Not Available

  • Trelew, Chubut
    Argentina

    Site Not Available

  • empty

    Ciudad Autonoma Bs As, Ciudad Autonoma Buenos Aires
    Argentina

    Site Not Available

  • Ciudad Autonoma de Buenos Aires, Ciudad Autonoma Buenos Aires
    Argentina

    Site Not Available

  • Córdoba, Cordoba
    Argentina

    Site Not Available

  • Villa Cabrera, Cordoba
    Argentina

    Site Not Available

  • Villa Maria, Cordoba
    Argentina

    Site Not Available

  • San Salvador de Jujuy, Jujy
    Argentina

    Site Not Available

  • Godoy Cruz, Mendoza
    Argentina

    Site Not Available

  • Cipolletti, Rio Negro
    Argentina

    Site Not Available

  • Venado Tuerto, Santa Fe
    Argentina

    Site Not Available

  • San Miguel de Tucuman, Tucuman
    Argentina

    Site Not Available

  • Ciudad Autonoma Buenos Aires,
    Argentina

    Site Not Available

  • Cordoba,
    Argentina

    Site Not Available

  • Corrientes,
    Argentina

    Site Not Available

  • Mendoza,
    Argentina

    Site Not Available

  • Rosario,
    Argentina

    Site Not Available

  • Salta,
    Argentina

    Site Not Available

  • Santa Fe,
    Argentina

    Site Not Available

  • Santiago del estero,
    Argentina

    Site Not Available

  • Bruce, Australian Capital Territory
    Australia

    Site Not Available

  • Canberra, Australian Capital Territory
    Australia

    Site Not Available

  • Garran, Australian Capital Territory
    Australia

    Site Not Available

  • Westmead, New South Wales
    Australia

    Site Not Available

  • Wollongong, New South Wales
    Australia

    Site Not Available

  • Brisbane, Queensland
    Australia

    Site Not Available

  • empty

    Herston, Queensland
    Australia

    Site Not Available

  • Meadowbrook, Queensland
    Australia

    Site Not Available

  • Milton, Queensland
    Australia

    Site Not Available

  • Townsville, Queensland
    Australia

    Site Not Available

  • Woolloongabba, Queensland
    Australia

    Site Not Available

  • Adelaide, South Australia
    Australia

    Site Not Available

  • Daw Park, South Australia
    Australia

    Site Not Available

  • Elizabeth Vale, South Australia
    Australia

    Site Not Available

  • Clayton, Victoria
    Australia

    Site Not Available

  • empty

    East Ringwood, Victoria
    Australia

    Site Not Available

  • Fitzroy, Victoria
    Australia

    Site Not Available

  • Geelong, Victoria
    Australia

    Site Not Available

  • Melbourne, Victoria
    Australia

    Site Not Available

  • Sale, Victoria
    Australia

    Site Not Available

  • Joondalup, Western Australia
    Australia

    Site Not Available

  • Fortaleza, Ceará
    Brazil

    Site Not Available

  • Brasilia, Distrito Federal
    Brazil

    Site Not Available

  • Goiania, Goiás
    Brazil

    Site Not Available

  • Campina Grande do Sul, Paraná
    Brazil

    Site Not Available

  • Curitiba, Paraná
    Brazil

    Site Not Available

  • Belem, Pará
    Brazil

    Site Not Available

  • Recife, Pernambuco
    Brazil

    Site Not Available

  • Canoas, Rio Grande do Sul
    Brazil

    Site Not Available

  • Caxias do Sul, Rio Grande do Sul
    Brazil

    Site Not Available

  • Passo Fundo, Rio Grande do Sul
    Brazil

    Site Not Available

  • Porto Alegre, Rio Grande do Sul
    Brazil

    Site Not Available

  • Santa Maria, Rio Grande do Sul
    Brazil

    Site Not Available

  • Marilia, Sao Paulo
    Brazil

    Site Not Available

  • São Paulo, Sao Paulo
    Brazil

    Site Not Available

  • Sao Paulo,
    Brazil

    Site Not Available

  • Blagoevgrad,
    Bulgaria

    Site Not Available

  • Byala,
    Bulgaria

    Site Not Available

  • Kazanlak,
    Bulgaria

    Site Not Available

  • Pazardzhik,
    Bulgaria

    Site Not Available

  • Plovdiv,
    Bulgaria

    Site Not Available

  • Sevlievo,
    Bulgaria

    Site Not Available

  • Sofia,
    Bulgaria

    Site Not Available

  • Stara Zagora,
    Bulgaria

    Site Not Available

  • Varna,
    Bulgaria

    Site Not Available

  • Calgary, Alberta
    Canada

    Site Not Available

  • Spruce Grove, Alberta
    Canada

    Site Not Available

  • Victoria, British Columbia
    Canada

    Site Not Available

  • Winnipeg, Manitoba
    Canada

    Site Not Available

  • Brampton, Ontario
    Canada

    Site Not Available

  • Etobicoke, Ontario
    Canada

    Site Not Available

  • Hamilton, Ontario
    Canada

    Site Not Available

  • Markham, Ontario
    Canada

    Site Not Available

  • Oakville, Ontario
    Canada

    Site Not Available

  • Ottawa, Ontario
    Canada

    Site Not Available

  • Sudbury, Ontario
    Canada

    Site Not Available

  • Thornhill, Ontario
    Canada

    Site Not Available

  • Toronto, Ontario
    Canada

    Site Not Available

  • Gatineau, Quebec
    Canada

    Site Not Available

  • Laval, Quebec
    Canada

    Site Not Available

  • Longueuil, Quebec
    Canada

    Site Not Available

  • empty

    Mirabel, Quebec
    Canada

    Site Not Available

  • Montreal, Quebec
    Canada

    Site Not Available

  • Pointe Claire, Quebec
    Canada

    Site Not Available

  • St-Jérôme, Quebec
    Canada

    Site Not Available

  • Ville Saint-Laurent, Quebec
    Canada

    Site Not Available

  • Quebec,
    Canada

    Site Not Available

  • Cakovec,
    Croatia

    Site Not Available

  • Karlovac,
    Croatia

    Site Not Available

  • Koprivnica,
    Croatia

    Site Not Available

  • Krapinske Toplice,
    Croatia

    Site Not Available

  • Osijek,
    Croatia

    Site Not Available

  • Rijeka,
    Croatia

    Site Not Available

  • Sisak,
    Croatia

    Site Not Available

  • Slavonski Brod,
    Croatia

    Site Not Available

  • Split,
    Croatia

    Site Not Available

  • Virovitica,
    Croatia

    Site Not Available

  • Zadar,
    Croatia

    Site Not Available

  • Zagreb,
    Croatia

    Site Not Available

  • Ceske Budejovice,
    Czech Republic

    Site Not Available

  • Chocen,
    Czech Republic

    Site Not Available

  • Jindrichuv Hradec,
    Czech Republic

    Site Not Available

  • Kromeriz,
    Czech Republic

    Site Not Available

  • Marianske Lazne,
    Czech Republic

    Site Not Available

  • Moravsky Krumlov,
    Czech Republic

    Site Not Available

  • Olomouc,
    Czech Republic

    Site Not Available

  • Ostrava,
    Czech Republic

    Site Not Available

  • Ostrava - Moravska Ostrava,
    Czech Republic

    Site Not Available

  • Ostrava - Vitkovice,
    Czech Republic

    Site Not Available

  • Prague 10,
    Czech Republic

    Site Not Available

  • Praha 4 - Krc,
    Czech Republic

    Site Not Available

  • Praha 5,
    Czech Republic

    Site Not Available

  • empty

    Praha 8,
    Czech Republic

    Site Not Available

  • Slany,
    Czech Republic

    Site Not Available

  • Trutnov,
    Czech Republic

    Site Not Available

  • Usti nad Labem,
    Czech Republic

    Site Not Available

  • Paide,
    Estonia

    Site Not Available

  • Tallinn,
    Estonia

    Site Not Available

  • Tartu,
    Estonia

    Site Not Available

  • Corbeil Essonne, Essonne
    France

    Site Not Available

  • Corbeil Essonnes, Essonne
    France

    Site Not Available

  • Pessac, Gironde
    France

    Site Not Available

  • Nanterre cedex, Hauts de Seine
    France

    Site Not Available

  • Nantes cedex 01, Loire Atlantique
    France

    Site Not Available

  • Pierre-Bénite cedex, Rhone
    France

    Site Not Available

  • Paris,
    France

    Site Not Available

  • Friedrichsthal, Baden Wuerttemberg
    Germany

    Site Not Available

  • Falkensee, Brandenburg
    Germany

    Site Not Available

  • Kelkheim, Hessen
    Germany

    Site Not Available

  • Dortmund, Nordrhein Westfalen
    Germany

    Site Not Available

  • empty

    Duesseldorf, Nordrhein Westfalen
    Germany

    Site Not Available

  • Essen, Nordrhein Westfalen
    Germany

    Site Not Available

  • Goch, Nordrhein Westfalen
    Germany

    Site Not Available

  • Kamp-Lintfort, Nordrhein Westfalen
    Germany

    Site Not Available

  • Koeln, Nordrhein Westfalen
    Germany

    Site Not Available

  • Bad Kreuznach, Rheinland Pfalz
    Germany

    Site Not Available

  • Dippoldiswalde, Sachsen
    Germany

    Site Not Available

  • Dresden, Sachsen
    Germany

    Site Not Available

  • Hohenmoelsen, Sachsen Anhalt
    Germany

    Site Not Available

  • Berlin,
    Germany

    Site Not Available

  • Hamburg,
    Germany

    Site Not Available

  • empty

    Guatemala,
    Guatemala

    Site Not Available

  • empty

    Guatemala City,
    Guatemala

    Site Not Available

  • empty

    Quetzaltenango,
    Guatemala

    Site Not Available

  • empty

    Zacapa,
    Guatemala

    Site Not Available

  • Hong Kong,
    Hong Kong

    Site Not Available

  • New Territories,
    Hong Kong

    Site Not Available

  • Baja,
    Hungary

    Site Not Available

  • Balatonfured,
    Hungary

    Site Not Available

  • Budaors,
    Hungary

    Site Not Available

  • Budapest,
    Hungary

    Site Not Available

  • Debrecen,
    Hungary

    Site Not Available

  • Eger,
    Hungary

    Site Not Available

  • Godollo,
    Hungary

    Site Not Available

  • Gyula,
    Hungary

    Site Not Available

  • Kecskemet,
    Hungary

    Site Not Available

  • Kistelek,
    Hungary

    Site Not Available

  • empty

    Kisvarda,
    Hungary

    Site Not Available

  • Komarom,
    Hungary

    Site Not Available

  • Mako,
    Hungary

    Site Not Available

  • Pecs,
    Hungary

    Site Not Available

  • Szeged,
    Hungary

    Site Not Available

  • Szekszard,
    Hungary

    Site Not Available

  • Szikszo,
    Hungary

    Site Not Available

  • Szombathely,
    Hungary

    Site Not Available

  • Urhida,
    Hungary

    Site Not Available

  • Veszprem,
    Hungary

    Site Not Available

  • Zalaegerszeg,
    Hungary

    Site Not Available

  • Ashkelon,
    Israel

    Site Not Available

  • Beer Sheva,
    Israel

    Site Not Available

  • Beer Yaakov,
    Israel

    Site Not Available

  • Beer-Sheva,
    Israel

    Site Not Available

  • Givataim,
    Israel

    Site Not Available

  • Hadera,
    Israel

    Site Not Available

  • Haifa,
    Israel

    Site Not Available

  • Holon,
    Israel

    Site Not Available

  • Jerusalem,
    Israel

    Site Not Available

  • Kfar-Saba,
    Israel

    Site Not Available

  • Petach Tikva,
    Israel

    Site Not Available

  • Petach Tikwa,
    Israel

    Site Not Available

  • empty

    Petach-Tikva,
    Israel

    Site Not Available

  • Raanana,
    Israel

    Site Not Available

  • empty

    Rechovot,
    Israel

    Site Not Available

  • Tel Aviv,
    Israel

    Site Not Available

  • Zefat,
    Israel

    Site Not Available

  • San Donato Milanese, Milano
    Italy

    Site Not Available

  • Sesto San Giovanni, Milano
    Italy

    Site Not Available

  • Firenze,
    Italy

    Site Not Available

  • Milano,
    Italy

    Site Not Available

  • Pavia,
    Italy

    Site Not Available

  • Wonju-Si, Gangwon-do
    Korea, Republic of

    Site Not Available

  • Seongnam-si, Gyeonggi-do
    Korea, Republic of

    Site Not Available

  • Yangsan-si, Gyeongsangnam-do
    Korea, Republic of

    Site Not Available

  • Jeonju-si, Jeollabuk-do
    Korea, Republic of

    Site Not Available

  • Busan,
    Korea, Republic of

    Site Not Available

  • Gyeonggi,
    Korea, Republic of

    Site Not Available

  • Seoul,
    Korea, Republic of

    Site Not Available

  • Daugavpils,
    Latvia

    Site Not Available

  • Jelgava,
    Latvia

    Site Not Available

  • Limbazi,
    Latvia

    Site Not Available

  • Ogre,
    Latvia

    Site Not Available

  • Riga,
    Latvia

    Site Not Available

  • Talsi,
    Latvia

    Site Not Available

  • Valmiera,
    Latvia

    Site Not Available

  • Alytus,
    Lithuania

    Site Not Available

  • Kaunas,
    Lithuania

    Site Not Available

  • Klaipeda,
    Lithuania

    Site Not Available

  • empty

    Vilnius,
    Lithuania

    Site Not Available

  • Johor Bahru, Johor
    Malaysia

    Site Not Available

  • Alor Setar, Kedah
    Malaysia

    Site Not Available

  • Kota Bahru, Kelantan
    Malaysia

    Site Not Available

  • Kota Bharu, Kelantan
    Malaysia

    Site Not Available

  • Lembah Pantai, Kuala Lumpur
    Malaysia

    Site Not Available

  • Ipoh, Perak
    Malaysia

    Site Not Available

  • Taiping, Perak
    Malaysia

    Site Not Available

  • Taiping, Perak, Perak
    Malaysia

    Site Not Available

  • Petaling Jaya, Selangor
    Malaysia

    Site Not Available

  • empty

    Alor Setar, Kedah,
    Malaysia

    Site Not Available

  • Kelantan,
    Malaysia

    Site Not Available

  • Kuala Lumpur,
    Malaysia

    Site Not Available

  • Melaka,
    Malaysia

    Site Not Available

  • Selangor,
    Malaysia

    Site Not Available

  • Terengganu,
    Malaysia

    Site Not Available

  • Tijuana, Baja California Norte
    Mexico

    Site Not Available

  • Torreon, Coahuila
    Mexico

    Site Not Available

  • Cuauhtemoc, Distrito Federal
    Mexico

    Site Not Available

  • Mexico, Distrito Federal
    Mexico

    Site Not Available

  • Cuautitlan Izcalli, Estado de Mexico
    Mexico

    Site Not Available

  • Metepec, Estado de Mexico
    Mexico

    Site Not Available

  • Acapulco de Juárez, Guerrero
    Mexico

    Site Not Available

  • Pachuca, Hidalgo
    Mexico

    Site Not Available

  • Guadalajara, Jalisco
    Mexico

    Site Not Available

  • Zapopan, Jalisco
    Mexico

    Site Not Available

  • Morelia, Michoacán
    Mexico

    Site Not Available

  • Cuernavaca, Morelos
    Mexico

    Site Not Available

  • Monterrey, Nuevo León
    Mexico

    Site Not Available

  • San Luis Potosi, San Luis Potos
    Mexico

    Site Not Available

  • Culiacan, Sinaloa
    Mexico

    Site Not Available

  • Xalapa, Veracruz
    Mexico

    Site Not Available

  • Merida, Yucatán
    Mexico

    Site Not Available

  • Aguascalientes,
    Mexico

    Site Not Available

  • Chihuahua,
    Mexico

    Site Not Available

  • Durango,
    Mexico

    Site Not Available

  • Tamaulipas,
    Mexico

    Site Not Available

  • Auckland,
    New Zealand

    Site Not Available

  • Christchurch,
    New Zealand

    Site Not Available

  • Dunedin,
    New Zealand

    Site Not Available

  • Palmerston North,
    New Zealand

    Site Not Available

  • Tauranga,
    New Zealand

    Site Not Available

  • Wellington,
    New Zealand

    Site Not Available

  • Callao,
    Peru

    Site Not Available

  • Cusco,
    Peru

    Site Not Available

  • Huacho,
    Peru

    Site Not Available

  • Ica,
    Peru

    Site Not Available

  • La Libertad,
    Peru

    Site Not Available

  • Lima,
    Peru

    Site Not Available

  • Piura,
    Peru

    Site Not Available

  • Baguio City,
    Philippines

    Site Not Available

  • Cebu City,
    Philippines

    Site Not Available

  • empty

    Dasmarinas City, Cavite,
    Philippines

    Site Not Available

  • Dasmariñas City, Cavite,
    Philippines

    Site Not Available

  • Davao City,
    Philippines

    Site Not Available

  • Iloilo City,
    Philippines

    Site Not Available

  • Marikina City,
    Philippines

    Site Not Available

  • Quezon City,
    Philippines

    Site Not Available

  • Tarlac,
    Philippines

    Site Not Available

  • Taytay,
    Philippines

    Site Not Available

  • Bialystok,
    Poland

    Site Not Available

  • Gdansk,
    Poland

    Site Not Available

  • Gliwice,
    Poland

    Site Not Available

  • Grodzisk Mazowiecki,
    Poland

    Site Not Available

  • Kamieniec Zabkowicki,
    Poland

    Site Not Available

  • empty

    Katowice,
    Poland

    Site Not Available

  • Leczyca,
    Poland

    Site Not Available

  • Lodz,
    Poland

    Site Not Available

  • Lublin,
    Poland

    Site Not Available

  • Oswiecim,
    Poland

    Site Not Available

  • Parczew,
    Poland

    Site Not Available

  • Poznan,
    Poland

    Site Not Available

  • Pulawy,
    Poland

    Site Not Available

  • Radom,
    Poland

    Site Not Available

  • Ruda Slaska,
    Poland

    Site Not Available

  • Rzeszow,
    Poland

    Site Not Available

  • empty

    Torun,
    Poland

    Site Not Available

  • Warszawa,
    Poland

    Site Not Available

  • Wroclaw,
    Poland

    Site Not Available

  • Bacau,
    Romania

    Site Not Available

  • Baia Mare,
    Romania

    Site Not Available

  • Brasov,
    Romania

    Site Not Available

  • Bucuresti,
    Romania

    Site Not Available

  • Galati,
    Romania

    Site Not Available

  • Iasi,
    Romania

    Site Not Available

  • Oradea,
    Romania

    Site Not Available

  • Ploiesti,
    Romania

    Site Not Available

  • Targu Mures,
    Romania

    Site Not Available

  • Timisoara,
    Romania

    Site Not Available

  • Arkhangelsk,
    Russian Federation

    Site Not Available

  • Barnaul,
    Russian Federation

    Site Not Available

  • Kazan,
    Russian Federation

    Site Not Available

  • Kemerovo,
    Russian Federation

    Site Not Available

  • empty

    Krasnoyarsk,
    Russian Federation

    Site Not Available

  • Moscow,
    Russian Federation

    Site Not Available

  • Nizhniy Novgorod,
    Russian Federation

    Site Not Available

  • Novosibirsk,
    Russian Federation

    Site Not Available

  • Pushkin,
    Russian Federation

    Site Not Available

  • empty

    Saint Petersburg,
    Russian Federation

    Site Not Available

  • Saratov,
    Russian Federation

    Site Not Available

  • St. Petersburg,
    Russian Federation

    Site Not Available

  • Yaroslavl,
    Russian Federation

    Site Not Available

  • Bratislava,
    Slovakia

    Site Not Available

  • Komarno,
    Slovakia

    Site Not Available

  • Kosice,
    Slovakia

    Site Not Available

  • Levice,
    Slovakia

    Site Not Available

  • Lucenec,
    Slovakia

    Site Not Available

  • Martin,
    Slovakia

    Site Not Available

  • Nitra,
    Slovakia

    Site Not Available

  • Nove Mesto nad Vahom,
    Slovakia

    Site Not Available

  • Presov,
    Slovakia

    Site Not Available

  • empty

    Prievidza,
    Slovakia

    Site Not Available

  • Sahy,
    Slovakia

    Site Not Available

  • Svidnik,
    Slovakia

    Site Not Available

  • Trencin,
    Slovakia

    Site Not Available

  • Zilina,
    Slovakia

    Site Not Available

  • Port Elizabeth, Eastern Cape
    South Africa

    Site Not Available

  • Bloemfontein, Free State
    South Africa

    Site Not Available

  • Johannesburg, Gauteng
    South Africa

    Site Not Available

  • Kempton Park, Gauteng
    South Africa

    Site Not Available

  • Krugersdorp, Gauteng
    South Africa

    Site Not Available

  • Lenasia, Gauteng
    South Africa

    Site Not Available

  • Pretoria, Gauteng
    South Africa

    Site Not Available

  • Durban, KwaZulu-Natal
    South Africa

    Site Not Available

  • Cape Town, Western Cape
    South Africa

    Site Not Available

  • Stellenbosch, Western Cape
    South Africa

    Site Not Available

  • Worcester, Western Cape
    South Africa

    Site Not Available

  • Douliou City,
    Taiwan

    Site Not Available

  • Kaohsiung,
    Taiwan

    Site Not Available

  • New Taipei City,
    Taiwan

    Site Not Available

  • Taichung,
    Taiwan

    Site Not Available

  • Tainan,
    Taiwan

    Site Not Available

  • Taipei,
    Taiwan

    Site Not Available

  • empty

    Taipei county,
    Taiwan

    Site Not Available

  • empty

    Yunlin County,
    Taiwan

    Site Not Available

  • Bangkoknoi, Bangkok
    Thailand

    Site Not Available

  • Dusit, Bangkok
    Thailand

    Site Not Available

  • Patumwan, Bangkok
    Thailand

    Site Not Available

  • Rachathevi, Bangkok
    Thailand

    Site Not Available

  • empty

    Rajathevee, Bangkok
    Thailand

    Site Not Available

  • Rajtevi, Bangkok
    Thailand

    Site Not Available

  • empty

    Rajthevee, Bangkok
    Thailand

    Site Not Available

  • Ratchathewi, Bangkok
    Thailand

    Site Not Available

  • Muang, Chiang Mai
    Thailand

    Site Not Available

  • empty

    Dnipropetrovsk,
    Ukraine

    Site Not Available

  • Donetsk,
    Ukraine

    Site Not Available

  • Kharkiv,
    Ukraine

    Site Not Available

  • Kyiv,
    Ukraine

    Site Not Available

  • Lugansk,
    Ukraine

    Site Not Available

  • empty

    Mykolaiv,
    Ukraine

    Site Not Available

  • Mykolayiv,
    Ukraine

    Site Not Available

  • Odesa,
    Ukraine

    Site Not Available

  • Poltava,
    Ukraine

    Site Not Available

  • Simferopol,
    Ukraine

    Site Not Available

  • Ternopil,
    Ukraine

    Site Not Available

  • Vinnycia,
    Ukraine

    Site Not Available

  • Vinnytsia,
    Ukraine

    Site Not Available

  • Zaporizhzhia,
    Ukraine

    Site Not Available

  • Truro, Cornwall
    United Kingdom

    Site Not Available

  • Exeter, Devon
    United Kingdom

    Site Not Available

  • Plymouth, Devon
    United Kingdom

    Site Not Available

  • Torquay, Devon
    United Kingdom

    Site Not Available

  • Hull, East Riding of Yorkshire
    United Kingdom

    Site Not Available

  • Bexhill on Sea, East Sussex
    United Kingdom

    Site Not Available

  • Portsmouth, Hampshire
    United Kingdom

    Site Not Available

  • Watford, Hertfordshire
    United Kingdom

    Site Not Available

  • Gillingham, Kent
    United Kingdom

    Site Not Available

  • Thornton-Cleveleys, Lancashire
    United Kingdom

    Site Not Available

  • Leicester, Leicestershire
    United Kingdom

    Site Not Available

  • Liverpool, Merseyside
    United Kingdom

    Site Not Available

  • Harrow, Middlesex
    United Kingdom

    Site Not Available

  • Northwood, Middlesex
    United Kingdom

    Site Not Available

  • Stoke on Trent, Staffordshire
    United Kingdom

    Site Not Available

  • Swansea, West Glamorgan
    United Kingdom

    Site Not Available

  • Cardiff,
    United Kingdom

    Site Not Available

  • Birmingham, Alabama
    United States

    Site Not Available

  • Dothan, Alabama
    United States

    Site Not Available

  • Mobile, Alabama
    United States

    Site Not Available

  • Muscle Shoals, Alabama
    United States

    Site Not Available

  • Pell City, Alabama
    United States

    Site Not Available

  • Goodyear, Arizona
    United States

    Site Not Available

  • Phoenix, Arizona
    United States

    Site Not Available

  • Tempe, Arizona
    United States

    Site Not Available

  • Tucson, Arizona
    United States

    Site Not Available

  • Little Rock, Arkansas
    United States

    Site Not Available

  • Anaheim, California
    United States

    Site Not Available

  • El Cajon, California
    United States

    Site Not Available

  • Fresno, California
    United States

    Site Not Available

  • Fullerton, California
    United States

    Site Not Available

  • empty

    La Jolla, California
    United States

    Site Not Available

  • La Mesa, California
    United States

    Site Not Available

  • Laguna Hills, California
    United States

    Site Not Available

  • Los Angeles, California
    United States

    Site Not Available

  • Mission Hills, California
    United States

    Site Not Available

  • empty

    Mission Viejo, California
    United States

    Site Not Available

  • National City, California
    United States

    Site Not Available

  • Newport Beach, California
    United States

    Site Not Available

  • Orange, California
    United States

    Site Not Available

  • Paramount, California
    United States

    Site Not Available

  • Pismo Beach, California
    United States

    Site Not Available

  • Redondo Beach, California
    United States

    Site Not Available

  • San Diego, California
    United States

    Site Not Available

  • San Francisco, California
    United States

    Site Not Available

  • San Franciso, California
    United States

    Site Not Available

  • Stockton, California
    United States

    Site Not Available

  • Thousand Oaks, California
    United States

    Site Not Available

  • Torrance, California
    United States

    Site Not Available

  • Valley Village, California
    United States

    Site Not Available

  • Westlake Village, California
    United States

    Site Not Available

  • Denver, Colorado
    United States

    Site Not Available

  • Lakewood, Colorado
    United States

    Site Not Available

  • Bridgeport, Connecticut
    United States

    Site Not Available

  • Danbury, Connecticut
    United States

    Site Not Available

  • Seaford, Delaware
    United States

    Site Not Available

  • Washington, District of Columbia
    United States

    Site Not Available

  • empty

    Boca Raton, Florida
    United States

    Site Not Available

  • Boynton Beach, Florida
    United States

    Site Not Available

  • Brandon, Florida
    United States

    Site Not Available

  • Chipley, Florida
    United States

    Site Not Available

  • Clearwater, Florida
    United States

    Site Not Available

  • Cocoa, Florida
    United States

    Site Not Available

  • Coral Gables, Florida
    United States

    Site Not Available

  • Coral Springs, Florida
    United States

    Site Not Available

  • Crystal River, Florida
    United States

    Site Not Available

  • Delray Beach, Florida
    United States

    Site Not Available

  • Hialeah, Florida
    United States

    Site Not Available

  • Hollywood, Florida
    United States

    Site Not Available

  • Inverness, Florida
    United States

    Site Not Available

  • Jacksonville, Florida
    United States

    Site Not Available

  • Jacksonville Beach, Florida
    United States

    Site Not Available

  • Melbourne, Florida
    United States

    Site Not Available

  • Miami, Florida
    United States

    Site Not Available

  • North Miami Beach, Florida
    United States

    Site Not Available

  • Ocala, Florida
    United States

    Site Not Available

  • Oviedo, Florida
    United States

    Site Not Available

  • Pembroke Pines, Florida
    United States

    Site Not Available

  • Sarasota, Florida
    United States

    Site Not Available

  • St. Petersburg, Florida
    United States

    Site Not Available

  • empty

    Sunrise, Florida
    United States

    Site Not Available

  • Tampa, Florida
    United States

    Site Not Available

  • Trinity, Florida
    United States

    Site Not Available

  • Vero Bearch, Florida
    United States

    Site Not Available

  • Atlanta, Georgia
    United States

    Site Not Available

  • Calhoun, Georgia
    United States

    Site Not Available

  • Conyers, Georgia
    United States

    Site Not Available

  • Cumming, Georgia
    United States

    Site Not Available

  • empty

    Decator, Georgia
    United States

    Site Not Available

  • Norcross, Georgia
    United States

    Site Not Available

  • Roswell, Georgia
    United States

    Site Not Available

  • Suwanee, Georgia
    United States

    Site Not Available

  • Woodstock, Georgia
    United States

    Site Not Available

  • Chicago, Illinois
    United States

    Site Not Available

  • LaGrange, Illinois
    United States

    Site Not Available

  • Anderson, Indiana
    United States

    Site Not Available

  • Avon, Indiana
    United States

    Site Not Available

  • Elkhart, Indiana
    United States

    Site Not Available

  • Greenfield, Indiana
    United States

    Site Not Available

  • Indianapolis, Indiana
    United States

    Site Not Available

  • Muncie, Indiana
    United States

    Site Not Available

  • empty

    Valparaiso, Indiana
    United States

    Site Not Available

  • Ames, Iowa
    United States

    Site Not Available

  • Council Bluffs, Iowa
    United States

    Site Not Available

  • Waterloo, Iowa
    United States

    Site Not Available

  • Augusta, Kansas
    United States

    Site Not Available

  • Hutchinson, Kansas
    United States

    Site Not Available

  • Newton, Kansas
    United States

    Site Not Available

  • Topeka, Kansas
    United States

    Site Not Available

  • Wichita, Kansas
    United States

    Site Not Available

  • Elizabethtown, Kentucky
    United States

    Site Not Available

  • empty

    Louisville, Kentucky
    United States

    Site Not Available

  • Marrero, Louisiana
    United States

    Site Not Available

  • Monroe, Louisiana
    United States

    Site Not Available

  • Natchitoches, Louisiana
    United States

    Site Not Available

  • New Orleans, Louisiana
    United States

    Site Not Available

  • Sherveport, Louisiana
    United States

    Site Not Available

  • Portland, Maine
    United States

    Site Not Available

  • Annapolis, Maryland
    United States

    Site Not Available

  • Balitmore, Maryland
    United States

    Site Not Available

  • Baltimore, Maryland
    United States

    Site Not Available

  • Fall River, Massachusetts
    United States

    Site Not Available

  • Hyannis, Massachusetts
    United States

    Site Not Available

  • Natick, Massachusetts
    United States

    Site Not Available

  • Bay City, Michigan
    United States

    Site Not Available

  • Cadillac, Michigan
    United States

    Site Not Available

  • Flint, Michigan
    United States

    Site Not Available

  • Kalamazoo, Michigan
    United States

    Site Not Available

  • Mt. Clemens, Michigan
    United States

    Site Not Available

  • Novi, Michigan
    United States

    Site Not Available

  • Pontiac, Michigan
    United States

    Site Not Available

  • Saginaw, Michigan
    United States

    Site Not Available

  • Troy, Michigan
    United States

    Site Not Available

  • Baxter, Minnesota
    United States

    Site Not Available

  • empty

    Saint Cloud, Minnesota
    United States

    Site Not Available

  • St. Cloud, Minnesota
    United States

    Site Not Available

  • St. Paul, Minnesota
    United States

    Site Not Available

  • Columbia, Missouri
    United States

    Site Not Available

  • Kansas City, Missouri
    United States

    Site Not Available

  • St. Louis, Missouri
    United States

    Site Not Available

  • Omaha, Nebraska
    United States

    Site Not Available

  • Las Vegas, Nevada
    United States

    Site Not Available

  • empty

    Amherst, New Hampshire
    United States

    Site Not Available

  • Nashua, New Hampshire
    United States

    Site Not Available

  • Bridgewater, New Jersey
    United States

    Site Not Available

  • Elizabeth, New Jersey
    United States

    Site Not Available

  • Haddon Heights, New Jersey
    United States

    Site Not Available

  • Linden, New Jersey
    United States

    Site Not Available

  • Mine Hill, New Jersey
    United States

    Site Not Available

  • Somerset, New Jersey
    United States

    Site Not Available

  • South Plainfield, New Jersey
    United States

    Site Not Available

  • Toms Rivers, New Jersey
    United States

    Site Not Available

  • Albuquerque, New Mexico
    United States

    Site Not Available

  • empty

    Bronx, New York
    United States

    Site Not Available

  • Brooklyn, New York
    United States

    Site Not Available

  • Buffalo, New York
    United States

    Site Not Available

  • Mineola, New York
    United States

    Site Not Available

  • New York, New York
    United States

    Site Not Available

  • Saratoga Springs, New York
    United States

    Site Not Available

  • Smithtown, New York
    United States

    Site Not Available

  • Syracuse, New York
    United States

    Site Not Available

  • Burlington, North Carolina
    United States

    Site Not Available

  • Calabash, North Carolina
    United States

    Site Not Available

  • Charlotte, North Carolina
    United States

    Site Not Available

  • Durham, North Carolina
    United States

    Site Not Available

  • Greensboro, North Carolina
    United States

    Site Not Available

  • Hickory, North Carolina
    United States

    Site Not Available

  • Lenoir, North Carolina
    United States

    Site Not Available

  • Mooresville, North Carolina
    United States

    Site Not Available

  • Morganton, North Carolina
    United States

    Site Not Available

  • Raleigh, North Carolina
    United States

    Site Not Available

  • Rocky Mount, North Carolina
    United States

    Site Not Available

  • empty

    Rocy Mount, North Carolina
    United States

    Site Not Available

  • Winston-Salem, North Carolina
    United States

    Site Not Available

  • Akron, Ohio
    United States

    Site Not Available

  • Canton, Ohio
    United States

    Site Not Available

  • Cincinnati, Ohio
    United States

    Site Not Available

  • Cleveland, Ohio
    United States

    Site Not Available

  • Columbus, Ohio
    United States

    Site Not Available

  • empty

    Fairfield, Ohio
    United States

    Site Not Available

  • Fairview Park, Ohio
    United States

    Site Not Available

  • Gallipolis, Ohio
    United States

    Site Not Available

  • Kettering, Ohio
    United States

    Site Not Available

  • Marion, Ohio
    United States

    Site Not Available

  • Middleburg Heights, Ohio
    United States

    Site Not Available

  • Perrysburg, Ohio
    United States

    Site Not Available

  • Springfield, Ohio
    United States

    Site Not Available

  • empty

    Tiffin, Ohio
    United States

    Site Not Available

  • Toledo, Ohio
    United States

    Site Not Available

  • Willoughby Hills, Ohio
    United States

    Site Not Available

  • Norman, Oklahoma
    United States

    Site Not Available

  • empty

    Oklahoma, Oklahoma
    United States

    Site Not Available

  • Oklahoma City, Oklahoma
    United States

    Site Not Available

  • Tulsa, Oklahoma
    United States

    Site Not Available

  • Chambersburg, Pennsylvania
    United States

    Site Not Available

  • Hanleysville, Pennsylvania
    United States

    Site Not Available

  • Harleysville, Pennsylvania
    United States

    Site Not Available

  • Levittown, Pennsylvania
    United States

    Site Not Available

  • Norristown, Pennsylvania
    United States

    Site Not Available

  • Philadelphi, Pennsylvania
    United States

    Site Not Available

  • Philadelphia, Pennsylvania
    United States

    Site Not Available

  • empty

    Red Lion, Pennsylvania
    United States

    Site Not Available

  • Scotland, Pennsylvania
    United States

    Site Not Available

  • Uniontown, Pennsylvania
    United States

    Site Not Available

  • East Providence, Rhode Island
    United States

    Site Not Available

  • Pawtucket, Rhode Island
    United States

    Site Not Available

  • Greer, South Carolina
    United States

    Site Not Available

  • Laurens, South Carolina
    United States

    Site Not Available

  • Simpsonville, South Carolina
    United States

    Site Not Available

  • Bristol, Tennessee
    United States

    Site Not Available

  • Crossville, Tennessee
    United States

    Site Not Available

  • Jackson, Tennessee
    United States

    Site Not Available

  • Kingsport, Tennessee
    United States

    Site Not Available

  • Nashville, Tennessee
    United States

    Site Not Available

  • Oak Ridge, Tennessee
    United States

    Site Not Available

  • Tullahoma, Tennessee
    United States

    Site Not Available

  • Austin, Texas
    United States

    Site Not Available

  • Carrollton, Texas
    United States

    Site Not Available

  • Dallas, Texas
    United States

    Site Not Available

  • Fort Worth, Texas
    United States

    Site Not Available

  • Houston, Texas
    United States

    Site Not Available

  • Irving, Texas
    United States

    Site Not Available

  • Katy, Texas
    United States

    Site Not Available

  • Midland, Texas
    United States

    Site Not Available

  • Odessa, Texas
    United States

    Site Not Available

  • Pearland, Texas
    United States

    Site Not Available

  • San Antonio, Texas
    United States

    Site Not Available

  • Spring, Texas
    United States

    Site Not Available

  • Tomball, Texas
    United States

    Site Not Available

  • Victoria, Texas
    United States

    Site Not Available

  • Bountiful, Utah
    United States

    Site Not Available

  • Layton, Utah
    United States

    Site Not Available

  • Salt Lake City, Utah
    United States

    Site Not Available

  • Alexandria, Virginia
    United States

    Site Not Available

  • Danville, Virginia
    United States

    Site Not Available

  • Falls Church, Virginia
    United States

    Site Not Available

  • Hampton, Virginia
    United States

    Site Not Available

  • Manassas, Virginia
    United States

    Site Not Available

  • Wenatchee, Washington
    United States

    Site Not Available

  • Huntington, West Virginia
    United States

    Site Not Available

  • Lewisburg, West Virginia
    United States

    Site Not Available

  • La Crosse, Wisconsin
    United States

    Site Not Available

  • Madison, Wisconsin
    United States

    Site Not Available

  • Milwaukee, Wisconsin
    United States

    Site Not Available

  • Wauwatosa, Wisconsin
    United States

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.