Phase 3 Safety and Efficacy Study of ART-123 in Subjects With Severe Sepsis and Coagulopathy

Last updated: April 18, 2020
Sponsor: Asahi Kasei Pharma America Corporation
Overall Status: Completed

Phase

3

Condition

Soft Tissue Infections

Blood Clots

Treatment

N/A

Clinical Study ID

NCT01598831
3-001
  • Ages > 18
  • All Genders

Study Summary

The purpose of the study is to evaluate if ART-123 given to patients who have severe sepsis can decrease mortality.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Subject must be receiving treatment in an ICU, or in an acute care setting (e.g., ER,RR)

  • Clinical objective evidence of bacterial infection and a known site of infection.

  • Cardiovascular dysfunction or Respiratory Failure due to sepsis.

  • Coagulopathy characterized by an INR >1.40 without other known causes.

Exclusion

Exclusion Criteria:

  • Subject or Authorized Representative is unable to provide informed consent.

  • Subject is pregnant or breastfeeding or intends to get pregnant within 28 days ofenrolling into the study.

  • Subject is of childbearing potential and does not have a negative pregnancy test.

  • Subject is < 18 years of age.

  • Subject has a known allergy to ART-123 or any components of the drug product.

  • Subject is unwilling to allow transfusion of blood or blood products.

  • Subject has an advance directive to withhold life-sustaining treatment.

  • Subject has had previous treatment with ART-123.

  • Body weight ≥ 175 kg.

  • Platelets < 30,000/ mm3 for any reason, PT prolongation or thrombocytopenia that isnot due to sepsis.

  • Any surgery that is potentially hemorrhagic (e.g. intra-thoracic, intra-abdominal ornon-traumatic orthopedic surgery of the femur or pelvis) that is completed within 12hours prior to first dose of study drug, or ongoing impairment of hemostasis as aresult of one of these procedures

  • History of head trauma, spinal trauma, or other acute trauma with an increased risk ofbleeding within 3 months prior to consent.

  • Cerebral Vascular Accident (CVA) within 3 months prior to consent.

  • Any history of intracerebral arteriovenous malformation (AVM), cerebral aneurysm, ormass lesions of the central nervous system.

  • History of congenital bleeding diathesesor anatomical anomaly that predisposes tohemorrhage (e.g. hemophilia, hereditary hemorrhagic telangiectasia).

  • Significant gastrointestinal bleeding within 6 weeks prior to consent.

  • Subject is diagnosed with a known medical condition associated with a hypercoagulablestate.

  • Child-Pugh score of 10-15 (Class C)

  • Portosystemic hypertension or known history of bleeding esophageal varices.

  • History of solid organ, allogeneic bone marrow, or stem cell transplantation withinthe 6 months prior to consent.

  • Acute pancreatitis where infection has not been documented by a positive blood orabdominal fluid culture or gram stain consistent with bacterial infection.

  • Subjects with renal dysfunction defined as (a) Chronic renal failure requiring renalreplacement therapy (RRT), or (b) Acute renal failure with onset of oliguria (urineoutput < 0.3 ml/kg/hr) > 48 hours prior to first dose of study drug whether receivingRRT or not

  • Use of anticoagulants, antiplatelet agents, antithrombotics and thrombolytics withinthe 72 hours prior to first does of study drug.

  • Life expectancy < 90 days.

  • Current use of any chemotherapy agent likely to cause myeloablation (severe orcomplete depletion of bone marrow).

  • Participation in another research study involving an investigational agent within 30days prior to consent or projected study participation during the 28 days post studyrandomization.

  • Confirmed or suspected endocarditis

Study Design

Total Participants: 816
Study Start date:
October 29, 2012
Estimated Completion Date:
February 28, 2019

Study Description

Study is to evaluate if ART-123 given to patients who have severe sepsis complicated by at least one organ dysfunction and coagulopathy can decrease mortality.

Connect with a study center

  • Instituto Medico Platense

    La Plata, Buenos Aires B1900AVG
    Argentina

    Site Not Available

  • Hospital Italiano de Cordoba

    Cordoba, X5004BAL
    Argentina

    Site Not Available

  • Calvary Health Care ACT

    Bruce, Australian Capital Territory
    Australia

    Site Not Available

  • Prince of Wales Hospital

    Randwick, New South Wales
    Australia

    Site Not Available

  • Royal Brisbane and Women's Hospital

    Herston, Queensland
    Australia

    Site Not Available

  • empty

    Nambour, Queensland
    Australia

    Site Not Available

  • Gold Coast Hospital

    Southport, Queensland
    Australia

    Site Not Available

  • Princess Alexandra Hospital

    Woolloongabba, Queensland
    Australia

    Site Not Available

  • Princess Alexandra Hospital

    Woolongabba, Queensland
    Australia

    Site Not Available

  • Royal Adelaide Hospital

    Adelaide, South Australia 5000
    Australia

    Site Not Available

  • Bendigo Hospital

    Bendigo, Victoria
    Australia

    Site Not Available

  • Monash Medical Centre

    Clayton, Victoria
    Australia

    Site Not Available

  • Dandenong Hospital Monash Health

    Dandenong, Victoria 3175
    Australia

    Site Not Available

  • Western Hospital

    Footscray, Victoria
    Australia

    Site Not Available

  • Austin Health

    Heidelberg, Victoria
    Australia

    Site Not Available

  • Sunshine Hospital

    Melbourne, Victoria 3021
    Australia

    Site Not Available

  • Epworth Health Care

    Richmond, Victoria
    Australia

    Site Not Available

  • Fremantle Hospital

    Fremantle, Western Australia
    Australia

    Site Not Available

  • empty

    Nedlands, Western Australia
    Australia

    Site Not Available

  • UZ Antwerpen

    Antwerpen,
    Belgium

    Site Not Available

  • Cliniques Du Sud-Luxerbourg (CSL), Hospital Saint Joseph

    Arlon,
    Belgium

    Site Not Available

  • CHU Brugmann

    Brussels,
    Belgium

    Site Not Available

  • Hopital Erasme

    Brussels,
    Belgium

    Site Not Available

  • Hopitaux Iris Sud

    Brussels,
    Belgium

    Site Not Available

  • UCL St. Luc

    Brussels,
    Belgium

    Site Not Available

  • UZ Brussel

    Brussels,
    Belgium

    Site Not Available

  • Centre Hospitalier de Dinant

    Dinant,
    Belgium

    Site Not Available

  • UZ Gent

    Gent,
    Belgium

    Site Not Available

  • Clinique Saint-Pierre

    Ottignies,
    Belgium

    Site Not Available

  • UCL Mont-Godinne

    Yvoir,
    Belgium

    Site Not Available

  • Santa Casa de Misericordia de Belo Horizonte

    Belo Horizonte, MG
    Brazil

    Site Not Available

  • Santa Casa de Misericordia de Porto Alegre

    Porto Alegre, RS 90020-090
    Brazil

    Site Not Available

  • Fundaçao Faculdade Regional de Medicina Sao Jose do Rio Preto

    Sao Jose do Rio Preto, SP
    Brazil

    Site Not Available

  • Hospital Samaritano

    São Paulo, SP 01232-010
    Brazil

    Site Not Available

  • Hospital Israelita Albert Einstein

    Morumbi, São Paulo 05651-901
    Brazil

    Site Not Available

  • Hospital Pompéia

    Brasil, 95010-005
    Brazil

    Site Not Available

  • empty

    Bulgaria, Plovdiv
    Bulgaria

    Site Not Available

  • Anesthesiology and Intensive Care Clinic, University Multiprofile Hospital For Active Treatment "Sveti Georgi", Plovdiv

    Plovdiv,
    Bulgaria

    Site Not Available

  • Department of Anesthesiology and Intensive Care Multiprofile Hospital For Active Treatment "Tokuda Hospital Sofia", Sofia

    Sofia,
    Bulgaria

    Site Not Available

  • Anesthesiology and Intensive Care Clinic

    Varna, 9010
    Bulgaria

    Site Not Available

  • 2 of 2

    Calgary, Alberta T1Y 6J4
    Canada

    Site Not Available

  • Calgary, Alberta T3M 1M4
    Canada

    Site Not Available

  • empty

    Edmonton, Alberta
    Canada

    Site Not Available

  • 2 of 2

    Vancouver, British Columbia V6Z 1Y6
    Canada

    Site Not Available

  • Vancouver, British Columbia V5Z 1M9
    Canada

    Site Not Available

  • 1 of 2

    Victoria, British Columbia V8R-1J8
    Canada

    Site Not Available

  • Victoria, British Columbia V8R1J8
    Canada

    Site Not Available

  • Winnipeg, Manitoba
    Canada

    Site Not Available

  • Halifax, Nova Scotia
    Canada

    Site Not Available

  • London, Ontario N6A5W9
    Canada

    Site Not Available

  • 1 of 2

    Ottawa, Ontario KIH 8L6
    Canada

    Site Not Available

  • 2 of 2

    Ottawa, Ontario KIH 8L6
    Canada

    Site Not Available

  • Mount Sinai Hospital

    Toronto, Ontario M5G 1X5
    Canada

    Site Not Available

  • Windsor, Ontario
    Canada

    Site Not Available

  • Montreal, Quebec
    Canada

    Site Not Available

  • empty

    Quebec, G1V 4G5
    Canada

    Site Not Available

  • empty

    Medelin, Antioquia
    Colombia

    Site Not Available

  • Hospital Pablo Tobon Uribe

    Medellin, Antioquia
    Colombia

    Site Not Available

  • Oncomedica S.A.

    Monteria, Cordoba
    Colombia

    Site Not Available

  • Fundacion Cardiovascular de Colombia

    Bucaramanga, Santander
    Colombia

    Site Not Available

  • empty

    Bogota,
    Colombia

    Site Not Available

  • Clinical Hospital Center Zagreb, Medical ICU

    Zagreb,
    Croatia

    Site Not Available

  • Clinical Hospital Dubrava, Department of Anesthesiology and resuscitation

    Zagreb,
    Croatia

    Site Not Available

  • University Hospital Center Zagreb, Department of Anesthesiology, Reanimatology and Intensive Care Medicine

    Zagreb,
    Croatia

    Site Not Available

  • Regional Hospital Kolin, a.s., Department of Anaesthesilogy and Resuscitation

    Kolin,
    Czech Republic

    Site Not Available

  • University Hospital Ostravam, Department of Anaesthesiology, Resuscitation and Intensive Medicine

    Ostrava - Poruba, 708 52
    Czech Republic

    Site Not Available

  • University Hospital Motol, Department of Anaesthesiology and Resuscitation CHU 2nd FM and UH Motol

    Prague, 15006
    Czech Republic

    Site Not Available

  • University Hospital Motol, Department of Anaesthesiology and Resuscitation CHU 2nd FM and UH Motol

    Prague 5 - Motol,
    Czech Republic

    Site Not Available

  • Regional Hospital T. Bati, PLC

    Zlin, 762 75
    Czech Republic

    Site Not Available

  • University Hospital Motol

    Praha, Czech Rep 15006
    Czechia

    Site Not Available

  • University Hospital Brno, Department of Infectious Diseases

    Brno,
    Czechia

    Site Not Available

  • University Hospital Hradec Kralove, Department of Anaesthesiology, Resuscitation and Intensive Care

    Hradec Kralove,
    Czechia

    Site Not Available

  • University Hospital Kralovske Vinohrady, Department of Anesthesiology and Resuscitation

    Prague 10,
    Czechia

    Site Not Available

  • General University Hospital in Prague, Department of Anaesthesiology, Resuscitation and Intensive Medicine

    Prague 2,
    Czechia

    Site Not Available

  • Masaryk´s Hospital Ustni nad Labem, o.z., Department of Infectious Diseases

    Usti nad Labem,
    Czechia

    Site Not Available

  • Helsingin Yliopistollinen Keskussairaala (HYKS) (Helsinki University Central Hospital (HUCH))

    Helsinki,
    Finland

    Site Not Available

  • Keski-Suomen Keskussairaala (Central Finland Central Hospital)

    Jyvaeskylae,
    Finland

    Site Not Available

  • Keski-Suomen Keskussairaala (Central Finland Central Hospital)

    Jyväskylä,
    Finland

    Site Not Available

  • Kuopion Yliopistollinen Sairaala (KYS) (Kuopio University Hospital)

    Kuopio,
    Finland

    Site Not Available

  • Etela-Pohjanmaan Sairaanhoitopiiri - Seinajoen Keskussairaala (Seinajoki Central Hospital)

    Seinajoki,
    Finland

    Site Not Available

  • Tampereen Yliopistollinen Sairaala (Tampere University Hospital) (TAYS) - Keskussairaala (Central Hospital)

    Tampere,
    Finland

    Site Not Available

  • Turku University Hospital

    Turku, 20520
    Finland

    Site Not Available

  • Archet 1 University Hospital of Nice

    Nice, Cedex 3 23079
    France

    Site Not Available

  • Service de reanimation médicale. CHU Hotel Dieu

    Nantes, Nantes Cedex 01 44093
    France

    Site Not Available

  • CHU D'Anger

    Angers Cedex 9,
    France

    Site Not Available

  • Centre hospitalier Sud-Francilien

    Corbeil-Essonnes,
    France

    Site Not Available

  • CHU de Dijon, Hopital Bocage Central

    Dijon, 21000
    France

    Site Not Available

  • CH-Hôpital Albert Michallon

    Grenoble cedex 09,
    France

    Site Not Available

  • Centre Hospitalier Départemental de Vendée-Les Oudairies

    La Roche-Sur-Yon cedex 9,
    France

    Site Not Available

  • Hôpital de Bicêtre - APHP

    Le Kremlin-Bicêtre,
    France

    Site Not Available

  • CHRU Lille-Pole Reanimation

    Lille, 59037
    France

    Site Not Available

  • CHU Limoges

    Limoges cedex,
    France

    Site Not Available

  • Hospices Civils de Lyon - Hopital de la Croix-Rousse

    Lyon, 69004
    France

    Site Not Available

  • Centre Hospitalier Universitaire Nîmes

    Nîmes Cedex 9,
    France

    Site Not Available

  • CHR Orléans, Hopital La Source

    Orléans,
    France

    Site Not Available

  • Hôpital COCHIN

    Paris,
    France

    Site Not Available

  • La Pitié Salpétrière, Paris

    Paris, 75013
    France

    Site Not Available

  • University Hospital of Bordeaux

    Pessac, 33600
    France

    Site Not Available

  • CH Lyon Sud

    Pierre-Bénite cedex,
    France

    Site Not Available

  • Centre Hospitalier Universitaire de Poitiers

    Poitiers cedex, 86021
    France

    Site Not Available

  • CH Angouleme, Saint Michel

    Saint Michel,
    France

    Site Not Available

  • Nouvel hospital civil

    Strasbourg, 67000
    France

    Site Not Available

  • Hôpital Sainte Musse

    Toulon,
    France

    Site Not Available

  • Hôpital Rangueil

    Toulouse,
    France

    Site Not Available

  • CHU Tours, Hopital Bretonneau

    Tours,
    France

    Site Not Available

  • Hôpital de Brabois Rue de Morvan

    Vandoeuvre-les-Nancy,
    France

    Site Not Available

  • Universitätsklinikum der RWTH Aachen

    Aachen, 54074
    Germany

    Site Not Available

  • Vivantes Klinikum Neukölln

    Berlin, 12351
    Germany

    Site Not Available

  • Helios Klinikum Erfurt

    Erfurt,
    Germany

    Site Not Available

  • Klinikum der Johann-Wolfgang Goethe-Universität

    Frankfurt am Main,
    Germany

    Site Not Available

  • Universitätsklinikum Jena

    Jena,
    Germany

    Site Not Available

  • Universitätsklinikum Leipzig AöR

    Leipzig,
    Germany

    Site Not Available

  • Klinikum Harlaching

    München,
    Germany

    Site Not Available

  • Evangelisches Krankenhaus Witten

    Witten,
    Germany

    Site Not Available

  • ATTIKO University Hospital

    Chaidari, Athens
    Greece

    Site Not Available

  • General Hospital of Chest Diseases "Sotiria"

    Athens,
    Greece

    Site Not Available

  • University Hospital of Ioannina

    Ioannina,
    Greece

    Site Not Available

  • General Hospital of Larissa ''Koutlimpanio & Triantafyllio''

    Larissa,
    Greece

    Site Not Available

  • Agioi Anargyroi Anticancer Hospital

    Nea Kifissia,
    Greece

    Site Not Available

  • Agioi Anargyroi Anticancer Hospital

    Néa Kifisiá,
    Greece

    Site Not Available

  • Szent Imre Hospital, Anesthesiology and Intensive Care Unit

    Budapest, 1115
    Hungary

    Site Not Available

  • Medical Center of the University of Pecs; Department of Anesthesiology and Intensive Care

    Pécs, 7623
    Hungary

    Site Not Available

  • Department of Anesthesiology and Intensive Care, Albert Szent-Gyorgyi Clinical Center, University of Szeged

    Szeged,
    Hungary

    Site Not Available

  • Maulana Azad Medical College and Associated L N Hospital

    New Delhi, Delhi
    India

    Site Not Available

  • Shalby

    Ahmedabad, Gujarat
    India

    Site Not Available

  • Shalby Hospital

    Ahmedabad,, Gujarat 380015
    India

    Site Not Available

  • Artemis Hospital

    Gurgaon, Haryana 122001
    India

    Site Not Available

  • empty

    Hubli, Karnataka
    India

    Site Not Available

  • SUT Hospital

    Trivandrum, Kerala
    India

    Site Not Available

  • King Edward Memorial Hospital & Research Centre

    Pune, Maharashtra
    India

    Site Not Available

  • Ruby Hall Clinic

    Pune, Maharashtra 411011
    India

    Site Not Available

  • Hi-tech Medical College & Hospital

    Bhubaneswar, Odisha
    India

    Site Not Available

  • Bharati Vidyapeeth Deemed University Medical College Bharti Hospital and Research Centre

    Katraj, Pune
    India

    Site Not Available

  • Bharati Vidyapeeth Deemed University Medical College Bharti Hospital and Research Centre

    Katraj Dhanakwadi, Pune, Maharashtra 411043
    India

    Site Not Available

  • Bharati Vidyapeeth Deemed University Medical College Bharti Hospital and Research Centre

    Pune, Pune, Maharashtra 411043
    India

    Site Not Available

  • Global Health City

    Chennai, Tamil Nadu 600100
    India

    Site Not Available

  • Meenakshi Mission Hospital and Research Centre

    Madurai, Tamilnadu
    India

    Site Not Available

  • St. Theresa Hospital

    Hyderabad, Telangana State 500018
    India

    Site Not Available

  • Mazumdar Shaw Medical Centre (Unit of Narayana Health)

    Bangalore, 560099
    India

    Site Not Available

  • KLES Dr. Prabhakar Kore Hospital & Medical Research Centre

    Belgaum, 590010
    India

    Site Not Available

  • Vintage Hospital & Medical Research Centre

    Goa, 403001
    India

    Site Not Available

  • JSS Hospital

    Mysore, 570004
    India

    Site Not Available

  • Care Hospital

    Nagpur, 440010
    India

    Site Not Available

  • Noble Hospital

    Pune, 411013
    India

    Site Not Available

  • Barzilai Medical Center

    Ashkelon,
    Israel

    Site Not Available

  • Hillel Yaffe Medical Center

    Hadera, 38100
    Israel

    Site Not Available

  • Rambam Medical Center

    Haifa,
    Israel

    Site Not Available

  • The Lady Davis Carmel Medical Center

    Haifa,
    Israel

    Site Not Available

  • Wolfson Medical Center

    Holon,
    Israel

    Site Not Available

  • Shaare Zedek Medical Center

    Jerusalem,
    Israel

    Site Not Available

  • Rabin Medical Center

    Petach Tikva,
    Israel

    Site Not Available

  • Kaplan Medical Center

    Rehovot,
    Israel

    Site Not Available

  • Busan Paik Hospital

    Busan,
    Korea, Republic of

    Site Not Available

  • Gachon University Gil Medical Center [Infectious Disease]

    Incheon,
    Korea, Republic of

    Site Not Available

  • Korea University Anam Hospital

    Seongbuk,
    Korea, Republic of

    Site Not Available

  • Korea University Anam Hospital

    Seongdu,
    Korea, Republic of

    Site Not Available

  • Asan Medical Center

    Seoul,
    Korea, Republic of

    Site Not Available

  • Samsung Medical Center [Pulmonology]

    Seoul,
    Korea, Republic of

    Site Not Available

  • Seoul National University Hospital

    Seoul,
    Korea, Republic of

    Site Not Available

  • Yonsei University Medical Center

    Soeul,
    Korea, Republic of

    Site Not Available

  • Jeroen Bosch Ziekenhuis

    's-Hertogenbosch,
    Netherlands

    Site Not Available

  • VUMC

    Amsterdam,
    Netherlands

    Site Not Available

  • Ziekenhuis Gelderse Vallei

    Ede,
    Netherlands

    Site Not Available

  • Medisch Spectrum Twente

    Enschede,
    Netherlands

    Site Not Available

  • University Medical Center Groningen

    Groningen,
    Netherlands

    Site Not Available

  • Atrium MC Heerlen

    Heerlen,
    Netherlands

    Site Not Available

  • Medisch Centrum Leeuwarden

    Leeuwarden,
    Netherlands

    Site Not Available

  • UMC St. Radboud

    Nijmegen,
    Netherlands

    Site Not Available

  • Ikazia Ziekenhuis

    Rotterdam,
    Netherlands

    Site Not Available

  • Auckland District Health Board

    Auckland,
    New Zealand

    Site Not Available

  • Christchurch Hospital

    Christchurch,
    New Zealand

    Site Not Available

  • Hawkes Bay Regional Hospital Intensive Care Unit Omahu Road

    Hastings,
    New Zealand

    Site Not Available

  • Wellington District Health Board

    Newtown, 6021
    New Zealand

    Site Not Available

  • Waikato District Health Board

    Waikato,
    New Zealand

    Site Not Available

  • Waikato District Health Board

    Waitakere,
    New Zealand

    Site Not Available

  • Hospital Nacional Almenara Yrigoyen - EsSALUD

    Lima, Lima Province
    Peru

    Site Not Available

  • Hospital Nacional FAP

    Lima, Lima Province
    Peru

    Site Not Available

  • Arkhangelsk Regional Clinical Hospital

    Arkhangelsk,
    Russian Federation

    Site Not Available

  • Volosevich City Clinical Hospital #1

    Arkhangelsk,
    Russian Federation

    Site Not Available

  • City Clinical Hospital #3 n.a. M.A. Pogorbunskiy

    Kemerovo, 650000
    Russian Federation

    Site Not Available

  • Kuban State Medical University (Site Facility: Krasnodar Regional Clinical Hospital #2)

    Krasnodar,
    Russian Federation

    Site Not Available

  • Krasnoyarsk Regional Clinocal Hospital

    Krasnoyarsk, 660022
    Russian Federation

    Site Not Available

  • Vishnevsky Institute of Surgery

    Moscow,
    Russian Federation

    Site Not Available

  • City Clinical Hospital #1

    Novosibirsk,
    Russian Federation

    Site Not Available

  • City Hospital #40

    Saint Petersburg,
    Russian Federation

    Site Not Available

  • St George City Hospital

    Saint Petersburg, 194354
    Russian Federation

    Site Not Available

  • City Hospital #4

    Sochi, 354057
    Russian Federation

    Site Not Available

  • Aleksandrovskaya City Hospital

    St. Petersburg,
    Russian Federation

    Site Not Available

  • Mariinskaya City Hospital

    St. Petersburg,
    Russian Federation

    Site Not Available

  • Mechnikov North-Western State Medical University n.a. I.I. Mechnikov

    St. Petersburg,
    Russian Federation

    Site Not Available

  • Clinical Centre Serbia,Center for Anestesiology and Reanimatology

    Belgrade,
    Serbia

    Site Not Available

  • Clinical Center Kragujevac, Center for Anesthesia and Reanimation

    Kragujevac,
    Serbia

    Site Not Available

  • Clinic for Infectious Diseases, Clinical Center Nis

    Nis,
    Serbia

    Site Not Available

  • Complexo Hospitalario Universitario A Coruña

    A Coruña,
    Spain

    Site Not Available

  • H. Universitario Príncipe de Asturias

    Alcalá de Henares,
    Spain

    Site Not Available

  • Hospital Universitario Mutua Terrassa Intensive Care

    Barcelona,
    Spain

    Site Not Available

  • Servicio de Medicina Intensiva Hospital Universitario Valle de Hebron

    Barcelona,
    Spain

    Site Not Available

  • Hospital de Gran Canaria Dr. Negrin

    Las Palmas de Gran Canaria,
    Spain

    Site Not Available

  • Hospital Clínico San Carlos

    Madrid,
    Spain

    Site Not Available

  • Hospital de Sabadell

    Sabadell,
    Spain

    Site Not Available

  • Complejo Hospitalario Nuestra Señora de Valme

    Sevilla,
    Spain

    Site Not Available

  • Hospital Universitari de Tarragona Joan XXIII

    Tarragona,
    Spain

    Site Not Available

  • Hospital de Txagorritxu

    Vitoria,
    Spain

    Site Not Available

  • Chi Mei Medical Center Yong Kang

    Yongkang, Tainan
    Taiwan

    Site Not Available

  • Taichung Veterans General Hospital [Pulmonology]

    Taichung,
    Taiwan

    Site Not Available

  • National Taiwan University Hospital

    Taipei,
    Taiwan

    Site Not Available

  • Lin Kou Chang Gung Memorial Hospital

    Taoyuan,
    Taiwan

    Site Not Available

  • Ankara University Medical Faculty Ibn-I Sina Hospital

    Ankara,
    Turkey

    Site Not Available

  • Trakya Universitesi Saglik Arastirma ve Uygulama Merkezi

    Edirne,
    Turkey

    Site Not Available

  • Istanbul University Cerrhapasa Medical Faculty

    Istanbul,
    Turkey

    Site Not Available

  • Dokuz Eylul University Medical Faculty

    İzmir,
    Turkey

    Site Not Available

  • Birmingham Heartlands Hospital

    Birmingham, B9 5SS
    United Kingdom

    Site Not Available

  • University Hospital of Wales

    Cardiff, CF14 4XW
    United Kingdom

    Site Not Available

  • James Paget University Hospital NHS Foundation Trust

    Great Yarmouth,
    United Kingdom

    Site Not Available

  • Hull Royal Infirmary

    Hull, HU3 2JZ
    United Kingdom

    Site Not Available

  • St. James's University Hospital

    Leeds,
    United Kingdom

    Site Not Available

  • Leicester Royal Infirmary

    Leicester,
    United Kingdom

    Site Not Available

  • Royal Liverpool University Hospital

    Liverpool,
    United Kingdom

    Site Not Available

  • Manchester Royal Infirmary

    Manchester,
    United Kingdom

    Site Not Available

  • Norfolk and Norwich University Hospital NHS Foundation Trust

    Norwich, NR4 7UY
    United Kingdom

    Site Not Available

  • Derriford Hospital

    Plymouth,
    United Kingdom

    Site Not Available

  • Musgrove Park Hospital

    Taunton,
    United Kingdom

    Site Not Available

  • Mobile, Alabama 36608
    United States

    Site Not Available

  • Phoenix, Arizona 85008
    United States

    Site Not Available

  • empty

    Tucson, Arizona 85724
    United States

    Site Not Available

  • empty

    Colton, California
    United States

    Site Not Available

  • empty

    Los Angeles, California
    United States

    Site Not Available

  • empty

    Sacramento, California
    United States

    Site Not Available

  • empty

    San Diego, California
    United States

    Site Not Available

  • Stanford University

    Stanford, California 94305
    United States

    Site Not Available

  • empty

    Newark, Delaware
    United States

    Site Not Available

  • empty

    Washington, District of Columbia
    United States

    Site Not Available

  • empty

    Washington, D.C., District of Columbia
    United States

    Site Not Available

  • empty

    Clearwater, Florida 33756
    United States

    Site Not Available

  • empty

    Miami, Florida 33125
    United States

    Site Not Available

  • empty

    Orlando, Florida 32804
    United States

    Site Not Available

  • Tampa General Hospital

    Tampa, Florida 33606
    United States

    Site Not Available

  • Atlanta, Georgia 30342
    United States

    Site Not Available

  • empty

    Augusta, Georgia
    United States

    Site Not Available

  • empty

    Canton, Georgia 30114
    United States

    Site Not Available

  • Idaho Falls, Idaho 83404
    United States

    Site Not Available

  • 2 of 2

    Chicago, Illinois 60611
    United States

    Site Not Available

  • empty

    Maywood, Illinois 60153
    United States

    Site Not Available

  • empty

    Oak Park, Illinois
    United States

    Site Not Available

  • empty

    Peoria, Illinois
    United States

    Site Not Available

  • Indianapolis, Indiana 46202
    United States

    Site Not Available

  • empty

    Iowa City, Iowa
    United States

    Site Not Available

  • empty

    Kansas City, Kansas 66160-7381
    United States

    Site Not Available

  • empty

    Topeka, Kansas
    United States

    Site Not Available

  • Hazard, Kentucky 41701
    United States

    Site Not Available

  • Louisville, Kentucky 40202
    United States

    Site Not Available

  • empty

    Baltimore, Maryland
    United States

    Site Not Available

  • empty

    Boston, Massachusetts 02115
    United States

    Site Not Available

  • empty

    Springfield, Massachusetts
    United States

    Site Not Available

  • empty

    Worcester, Massachusetts 01655
    United States

    Site Not Available

  • Detroit Receiving Hospital

    Detroit, Michigan 48201
    United States

    Site Not Available

  • Harper Hospital - Wayne State University School of Medicine

    Detroit, Michigan 48201
    United States

    Site Not Available

  • Sinai-Grace Hospital

    Detroit, Michigan 48235
    United States

    Site Not Available

  • empty

    Saint Paul, Minnesota 55101
    United States

    Site Not Available

  • empty

    St. Paul, Minnesota 55101
    United States

    Site Not Available

  • Jackson, Mississippi 39216
    United States

    Site Not Available

  • Washington University in St. Louis

    Saint Louis, Missouri 63110
    United States

    Site Not Available

  • empty

    St. Louis, Missouri
    United States

    Site Not Available

  • Butte, Montana 59701
    United States

    Site Not Available

  • empty

    Omaha, Nebraska
    United States

    Site Not Available

  • empty

    Camden, New Jersey
    United States

    Site Not Available

  • Englewood, New Jersey 07631
    United States

    Site Not Available

  • empty

    Hackensack, New Jersey 07601
    United States

    Site Not Available

  • empty

    Buffalo, New York
    United States

    Site Not Available

  • empty

    Mineola, New York
    United States

    Site Not Available

  • Memorial Sloan Kettering Cancer Center

    New York, New York 10065
    United States

    Site Not Available

  • empty

    Asheville, North Carolina
    United States

    Site Not Available

  • empty

    Chapel Hill, North Carolina
    United States

    Site Not Available

  • Durham, North Carolina 27710
    United States

    Site Not Available

  • empty

    Greensboro, North Carolina
    United States

    Site Not Available

  • empty

    Greenville, North Carolina
    United States

    Site Not Available

  • empty

    Winston-Salem, North Carolina
    United States

    Site Not Available

  • empty

    Cleveland, Ohio
    United States

    Site Not Available

  • empty

    Colombus, Ohio
    United States

    Site Not Available

  • Columbus, Ohio 43215
    United States

    Site Not Available

  • empty

    Toledo, Ohio
    United States

    Site Not Available

  • empty

    Oklahoma, Oklahoma
    United States

    Site Not Available

  • Oklahoma City, Oklahoma 73104
    United States

    Site Not Available

  • empty

    Portland, Oregon
    United States

    Site Not Available

  • Philadelphia, Pennsylvania 19104
    United States

    Site Not Available

  • Rapid City, South Dakota 57701
    United States

    Site Not Available

  • empty

    Nashville, Tennessee 37232-2560
    United States

    Site Not Available

  • empty

    Austin, Texas 78752
    United States

    Site Not Available

  • Baylor University Medical Center

    Dallas, Texas 75246
    United States

    Site Not Available

  • 2 of 2

    Houston, Texas 77030
    United States

    Site Not Available

  • Murray, Utah 84107
    United States

    Site Not Available

  • empty

    Falls Church, Virginia 22042
    United States

    Site Not Available

  • empty

    Everett, Washington
    United States

    Site Not Available

  • empty

    Milwaukee, Wisconsin 53226
    United States

    Site Not Available

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