An Extension Study to Provide Continued Bevacizumab Therapy to Participants With Solid Tumors Who Were Previously Enrolled in a Roche/Genentech Sponsored Study

Last updated: October 15, 2020
Sponsor: Hoffmann-La Roche
Overall Status: Completed

Phase

4

Condition

Neoplasms

Treatment

N/A

Clinical Study ID

NCT01588184
MO25757
2011-002009-31
  • Ages > 18
  • All Genders

Study Summary

This single-arm, open-label, multicenter extension study will provide continued bevacizumab therapy to participants with solid tumors who were previously enrolled in a Roche/Genentech sponsored study and who derived benefit from the bevacizumab therapy. Participants will receive the same dose and regimen of bevacizumab as used in the previous parent trial and continue this treatment until progression of disease or unacceptable toxicity, withdrawal of consent or death whichever occurs first.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Participant is treated with bevacizumab at the end of the Roche/Genentech sponsoredparent trial and continues to have benefit as judged by the investigator
  • Eligible for continuation of bevacizumab treatment at the end of a parent trial,according to parent trial protocol
  • Able to comply with this extension study protocol (MO25757)

Exclusion

Exclusion Criteria:

  • Evidence of disease progression assessed according to parent trial protocol during thescreening phase for this extension study
  • Evidence of any adverse event potentially attributable to bevacizumab, for which thelocal label recommends permanent discontinuation
  • A treatment interruption with bevacizumab of more than 42 days since the lastadministration of bevacizumab in the parent trial
  • Evidence of any other disease that would put the participant at high risk fortreatment-related complications

Study Design

Total Participants: 95
Study Start date:
July 13, 2012
Estimated Completion Date:
September 27, 2019

Connect with a study center

  • empty

    Rosario, S2002KDS
    Argentina

    Site Not Available

  • Medizinische Universität Graz; Universitätsklinik für Neurologie

    Graz, 8036
    Austria

    Site Not Available

  • Uniklinik fuer Neurologie, Medizinische Universitaet Innsbruck; Department fuer Neurologie

    Innsbruck, 6020
    Austria

    Site Not Available

  • A.Ö. LKH; Abt. für Lungenkrankheiten

    Steyr, 4400
    Austria

    Site Not Available

  • Hospital Araujo Jorge; Departamento de Ginecologia E Mama

    Goiania, GO 74605-070
    Brazil

    Site Not Available

  • Instituto de Oncologia do Paraná

    Curitiba, PR 80530-010
    Brazil

    Site Not Available

  • Instituto Nacional de Cancer - INCa; Pesquisa Clinica

    Rio de Janeiro, RJ 20230-130
    Brazil

    Site Not Available

  • Hospital de Caridade de Ijui; Oncologia

    Ijui, RS 98700-000
    Brazil

    Site Not Available

  • Hospital Sao Lucas - PUCRS

    Porto Alegre, RS 90610-000
    Brazil

    Site Not Available

  • Hospital de Cancer de Barretos

    Barretos, SP 14784-400
    Brazil

    Site Not Available

  • Faculdade de Medicina do ABC - FMABC; Oncologia e Hematologia

    Santo Andre, SP 09060-650
    Brazil

    Site Not Available

  • Hospital A. C. Camargo; Oncologia

    Sao Paulo, SP 01509-010
    Brazil

    Site Not Available

  • Hospital Perola Byington

    Sao Paulo, SP 01317-000
    Brazil

    Site Not Available

  • Instituto do Cancer do Estado de Sao Paulo - ICESP

    Sao Paulo, SP 01246-000
    Brazil

    Site Not Available

  • Hospital Sao Jose

    São Paulo, SP CEP 01321-001
    Brazil

    Site Not Available

  • MBAL Serdika EOOD

    Sofia, 1632
    Bulgaria

    Site Not Available

  • University Health Network; Princess Margaret Hospital; Medical Oncology Dept

    Toronto, Ontario M5G 2M9
    Canada

    Site Not Available

  • Fakultni nemocnice Olomouc; Onkologicka klinika

    Olomouc, 779 00
    Czechia

    Site Not Available

  • empty

    Tallin, 11619
    Estonia

    Site Not Available

  • North Estonia Medical Centre Foundation; Oncology Center

    Tallinn, 13419
    Estonia

    Site Not Available

  • HOPITAL JEAN MINJOZ; Oncologie

    Besancon, 25030
    France

    Site Not Available

  • Centre Leonard De Vinci;Chimiotherapie

    Dechy, 59187
    France

    Site Not Available

  • Centre Georges François Leclerc; Service Pharmacie, Bp 77980

    Dijon, 21000
    France

    Site Not Available

  • Hopital Roger Salengro; Service de Neurologie

    Lille,
    France

    Site Not Available

  • Centre Leon Berard; Departement Oncologie Medicale

    Lyon, 69373
    France

    Site Not Available

  • Centre Paul Strauss; Oncologie Medicale

    Strasbourg, 67065
    France

    Site Not Available

  • Hopital Larrey; Pneumologie

    Toulouse, 31059
    France

    Site Not Available

  • Universitätsklinikum Bonn; Medizinische Klinik und Poliklinik I; Allgemeine Innere Medizin

    Bonn, 53127
    Germany

    Site Not Available

  • Klinikum Essen-Mitte Ev. Huyssens-Stiftung / Knappschafts GmbH; Klinik für Senologie / Brustzentrum

    Essen, 45136
    Germany

    Site Not Available

  • Klinikum Joh.Wolfg.Goethe-UNI Senckenbergisches Institut für Neuroonkologie

    Frankfurt am Main, 60528
    Germany

    Site Not Available

  • empty

    Grosshansdorf, 22927
    Germany

    Site Not Available

  • LungenClinic Großhansdorf GmbH

    Großhansdorf, 22927
    Germany

    Site Not Available

  • Universitätsklinikum Münster Klinik u. Poliklinik f. Neurologie

    Münster, 48149
    Germany

    Site Not Available

  • Universitätsklinik Tübingen; Frauenklinik

    Tübingen, 72076
    Germany

    Site Not Available

  • Orszagos Onkologiai Intezet; Nogyogyaszati Osztaly

    Budapest, 1122
    Hungary

    Site Not Available

  • A.O. Universitaria Federico II Di Napoli; Oncologia Ed Endocrinologia Clinica

    Napoli, Campania 80131
    Italy

    Site Not Available

  • Azienda Ospedaliero-Universitaria S.Orsola-Malpighi; Unità Operativa Oncologia Medica

    Bologna, Emilia-Romagna 40138
    Italy

    Site Not Available

  • Azienda Ospedaliera San Camillo Forlanini; U.O.C. Pneumologia Ad Indirizzo Oncologico 1

    Roma, Lazio 00152
    Italy

    Site Not Available

  • Fondazione IRCCS Istituto Neurologico C. Besta; Neuro-oncologia Sperimentale e Terapia Genica

    Milano, Lombardia 20133
    Italy

    Site Not Available

  • Irccs Istituto Europeo Di Oncologia (IEO); Oncologia Medica

    Milano, Lombardia 20141
    Italy

    Site Not Available

  • ASST DI MONZA; Oncologia Medica

    Monza, Lombardia 20900
    Italy

    Site Not Available

  • ASST LARIANA; Oncologia

    S. Fermo Della Battaglia (CO), Lombardia 22020
    Italy

    Site Not Available

  • Azienda Ospedaliera Le Molintte di Torino; Dipartimento Di Neurologia - Oncologia

    Torino, Piemonte 10126
    Italy

    Site Not Available

  • Ospedale Antonio Perrino; Oncologia Medica

    Brindisi, Puglia 72100
    Italy

    Site Not Available

  • Centro Catanese Di Oncologia; Oncologia Medica

    Catania, Sicilia 95126
    Italy

    Site Not Available

  • Ospedale Nuovo Della Versilia; Divisione Di Oncologia Medica

    Lido Di Camaiore, Toscana 55043
    Italy

    Site Not Available

  • A.O. Universitaria Pisana-Ospedale Cisanello; Dipartimento Cardio Toracico-Pneumologia Ii

    Pisa, Toscana 56124
    Italy

    Site Not Available

  • Ospedale Misericordia E Dolce; Oncologia Medica

    Prato, Toscana 59100
    Italy

    Site Not Available

  • Azienda Ospedaliera S. Maria - Terni; Oncologia

    Terni, Umbria 05100
    Italy

    Site Not Available

  • empty

    Como, 22100
    Italy

    Site Not Available

  • empty

    S Fermo Della Battaglia, 22020
    Italy

    Site Not Available

  • National Cancer Center; Medical Oncology

    Gyeonggi-do, 410-769
    Korea, Republic of

    Site Not Available

  • empty

    Kyunggi-do, 411-769
    Korea, Republic of

    Site Not Available

  • Asan Medical Center, Uni Ulsan Collegemedicine; Dept.Internal Medicine / Divisionhematology/Oncology

    Seoul, 138-736
    Korea, Republic of

    Site Not Available

  • Severance Hospital; Internal Medicine

    Seoul, 110-744
    Korea, Republic of

    Site Not Available

  • Instituto Nacional de Cancerologia; Oncology

    Distrito Federal, 14080
    Mexico

    Site Not Available

  • Fundación Rodolfo Padilla Padilla, A.C.; Oncology

    Leon, 37000
    Mexico

    Site Not Available

  • empty

    Mexico City, 06760
    Mexico

    Site Not Available

  • Oaxaca Site Management Organization

    Oaxaca, 68000
    Mexico

    Site Not Available

  • Leyenburg Hospital; Pulmonology

    Den Haag, 2504 LN
    Netherlands

    Site Not Available

  • Radboud Ziekenhuis; Urologie, 659

    Nijmegen, 6525 GA
    Netherlands

    Site Not Available

  • Prof. Dr. I. Chiricuta Institute of Oncology

    Cluj Napoca, 400015
    Romania

    Site Not Available

  • Euroclinic Center of Oncology SRL

    Iasi, 700106
    Romania

    Site Not Available

  • Altai Region Oncology Dispensory; Oncology

    Barnaul, 656049
    Russian Federation

    Site Not Available

  • Regional Oncology Hospital; Oncology

    Irkutsk, 664035
    Russian Federation

    Site Not Available

  • Blokhin Cancer Research Center; Combined Treatment

    Moscow, 115478
    Russian Federation

    Site Not Available

  • City Clinical Oncology Hospital

    Moscow, 143423
    Russian Federation

    Site Not Available

  • P.A. Gertsen Cancer Research Inst. ; Chemotherapy Dept

    Moscow, 125284
    Russian Federation

    Site Not Available

  • Russian Research Center of Roentgenoradiology; Dept of Chemotherapy

    Moscow, 117837
    Russian Federation

    Site Not Available

  • empty

    Obninsk, 249020
    Russian Federation

    Site Not Available

  • Medical Radiological Scientific Center; Department of Radiotherapy of Gynaecological Disease

    Obninsk, Kaluzhskaya Region, 249034
    Russian Federation

    Site Not Available

  • Bashkirian Republican Clinical Oncology Dispensary

    UFA, 450054
    Russian Federation

    Site Not Available

  • Vychodoslovensky onkologicky ustav

    Kosice, 04001
    Slovakia

    Site Not Available

  • Vychodoslovensky onkologicky ustav

    Koslce, 004191
    Slovakia

    Site Not Available

  • Vychodoslovensky onkologicky ustav

    Košice, 040 01
    Slovakia

    Site Not Available

  • empty

    Johannesburg, 2193
    South Africa

    Site Not Available

  • Wits Donald Gordon Clinical Trial Centre; Medical Oncology

    Parktown, Johannesburg, 2193
    South Africa

    Site Not Available

  • Hospital de Cruces; Servicio de Oncologia

    Barakaldo, Vizcaya 48903
    Spain

    Site Not Available

  • Hospital de Basurto; Servicio de Oncologia

    Bilbao, Vizcaya 48013
    Spain

    Site Not Available

  • Hospital de Cruces; Servicio de Oncologia

    Bilbao, Vizcaya 48903
    Spain

    Site Not Available

  • Complejo Asistencial Universitario De Burgos; Servicio de Oncologia

    Burgos, 09006
    Spain

    Site Not Available

  • Hospital Provincial de Castellon; Servicio de Oncologia

    Castellon, 12002
    Spain

    Site Not Available

  • Hospital Reina Sofia; Medical Oncology

    Cordoba, 14004
    Spain

    Site Not Available

  • Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia

    Jaen, 23007
    Spain

    Site Not Available

  • Complejo Hospitalario Universitario A Coruña (CHUAC, Materno Infantil), Oncología

    La Coruña, 15006
    Spain

    Site Not Available

  • Hospital Gregorio Marañon

    Madrid, 28007
    Spain

    Site Not Available

  • Hospital Universitario 12 de Octubre; Servicio de Oncologia

    Madrid, 28041
    Spain

    Site Not Available

  • Hospital Universitario La Paz; Servicio de Oncologia

    Madrid, 28046
    Spain

    Site Not Available

  • Hospital Regional Universitario Carlos Haya; Servicio de Oncologia

    Malaga, 29010
    Spain

    Site Not Available

  • Complejo Hospitalario de Toledo- H. Virgen de la Salud; Servicio de Oncologia

    Toledo, 45004
    Spain

    Site Not Available

  • Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia

    Valencia, 46010
    Spain

    Site Not Available

  • Mälarsjukhuset, Eskilstuna, Kvinnokliniken

    Eskilstuna, 63188
    Sweden

    Site Not Available

  • Norrlands universitetssjukhus; Onkologkliniken

    Umeå,
    Sweden

    Site Not Available

  • Universitetssjukhuset Örebro, Onkologiska kliniken

    Örebro, 701 85
    Sweden

    Site Not Available

  • Adana City Hospital, Medical Oncology

    Adana, 01060
    Turkey

    Site Not Available

  • Bristol Haematology and Oncology Centre

    Bristol, BS2 8ED
    United Kingdom

    Site Not Available

  • Addenbrooke'S Hospital; Dept of Neurosurgery

    Cambridge, CB2 2QQ
    United Kingdom

    Site Not Available

  • empty

    Denbigh, LL18 5UJ
    United Kingdom

    Site Not Available

  • Christie Hospital Nhs Trust; Medical Oncology

    Manchester, M2O 4BX
    United Kingdom

    Site Not Available

  • North Wales Cancer Treatment Centre, Glan Clwyd Hospital

    Rhyl, LL18 5UJ
    United Kingdom

    Site Not Available

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