European Sapheon™ Closure System Observational ProspectivE (eSCOPE) Study

Inclusion Criteria:

• Age ≥18 years and ≤ 70 years of age.

• Symptomatic primary Great Saphenous Vein "GSV" incompetence diagnosed by clinicalsymptoms, with or without visible varicosities, and confirmed by duplex ultrasoundimaging.

• CEAP classification of C2, C3 or C4.

• Ability to walk unassisted.

• Ability to attend follow-up visits.

• Ability to understand the requirements of the study and to provide written informedconsent.

• "GSV" on standing pre-procedure Doppler Ultrasound ≥3mm and ≤10mm (maximum diameter).

Exclusion Criteria:

• Life expectancy < 1 year.

• Regular pain medication.

• Anticoagulation including Heparin or Coumadin.

• Previous Deep Vein Thrombosis "DVT".

• Previous superficial thrombophlebitis in "GSV".

• Previous venous treatment on target limb.

• Known Hyper-coagulable disorder.

• Conditions which prevent routine vein treatment like:

• Acute disease,

• Immobilization or inability to ambulate, and

• Pregnancy.

• Tortuous "GSV", which in the opinion of the Investigator will limit catheterplacement. (no 2 primary access sites allowed).

• Incompetent ipsilateral small saphenous or anterior accessory great saphenous vein.

• Known sensitivity to the cyanoacrylate "CA" adhesive.

• Current participation in another clinical study involving an investigational agent ortreatment, or within the 30 days prior to enrollment.