GRoup A StrePtococcus

Last updated: March 17, 2025
Sponsor: University of Wisconsin, Madison
Overall Status: Active - Recruiting

Phase

N/A

Condition

Pharyngitis

Strep Throat

Throat And Tonsil Infections

Treatment

Identifying group A strep carriers

Clinical Study ID

NCT01558804
2011-0058
SMPH\PEDIATRICS\PEDIATRICS
2015-1456
Protocol Version 9/14/2023
1R21AI147502-01
A536700
  • Ages 5-15
  • All Genders

Study Summary

The purpose of the research is to help understand why some children become carriers of strep and whether children who are carriers need to be treated with antibiotics.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Children ages 5-15 years

  • Positive rapid antigen detection test for group A streptococcus

  • Parent or legal guardian present and able to provide consent

  • Provider prescribes treatment with a beta lactam antibiotic

  • English speaking

Exclusion

Exclusion Criteria:

  • Unable to take beta lactam antibiotics

  • Other concurrent bacterial infection, i.e., pneumonia

Study Design

Total Participants: 180
Treatment Group(s): 1
Primary Treatment: Identifying group A strep carriers
Phase:
Study Start date:
May 09, 2011
Estimated Completion Date:
June 30, 2026

Study Description

The overall objective of this investigation is to understand the differences in Group A streptococci in children who are acutely infected from those who are carriers. The hypothesis is that when in the carrier state, GAS exhibits unique transcriptional profiles that differ from those of the acute infection state. The investigators expect transcriptional profiles of GAS to provide important information regarding the changes the organism undergoes when transitioning between acute infection and carriage.

The specific aims of this study are:

  1. To collect longitudinal participant-samples from acute and carriage phases of GAS infection and compare transcriptomic profiles and whole genome sequences of GAS recovered from acute and carrier pharyngeal swabs obtained from the same participants.

  2. To evaluate how identified differentially expressed genes, or observed genetic polymorphisms, influence GAS models of bacterial colonization and pathogenesis.

To do this, the investigators will to identify 12 children with acute pharyngitis due to Group A streptococcus (GAS) who are pharyngeal carriers of GAS. Thirty percent of children 4 to 16 years of age with acute pharyngitis occurring between October and May will have a positive culture or rapid antigen detection test for GAS. Approximately 8-10% of these children with pharyngitis and a positive culture or rapid antigen detection test (RADT) for GAS will be carriers. Therefore,180 participants will need to be enrolled.

Connect with a study center

  • UW Health Pediatric Clinics

    Madison, Wisconsin 53717
    United States

    Active - Recruiting

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