Effects of Lifestyle-modification Induced Weight Loss on Sexual and Urinary Function, and Quality of Life in Obese Men

Last updated: July 27, 2015
Sponsor: Changi General Hospital
Overall Status: Completed

Phase

4

Condition

Inflammation

Impotence

Weight Loss

Treatment

N/A

Clinical Study ID

NCT01554735
12200233
  • Ages 30-65
  • Male
  • Accepts Healthy Volunteers

Study Summary

This study aims to evaluate the extent to which weight loss of 5-10% from baseline, induced by exercise and diet, improves metabolic and inflammatory profile, endothelial function, erectile function, sexual desire, lower urinary tract symptoms (LUTS), and quality of life in obese men.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Male, aged 30-65 years

  • Body Mass Index (BMI) >/= 27.5 kg/m2

  • Waist circumference (WC) >/= 90 cm

Exclusion

Exclusion Criteria:

  • pituitary disease or cranial radiotherapy

  • previous or current androgen replacement or deprivation therapy

  • current treatment for sexual problems or LUTS

  • glomerular filtration rate < 60 ml/min

  • liver disease

  • alcohol intake exceeding 500 g/week in the previous 12 months

  • use of opiates, glucocorticoids, recreational drugs or phosphodiesterase inhibitors

Study Design

Total Participants: 70
Study Start date:
July 01, 2010
Estimated Completion Date:
June 30, 2013

Study Description

This study aims to evaluate the extent to which weight loss of 5-10% from baseline, induced by exercise and diet, improves metabolic and inflammatory profile, endothelial function, erectile function, sexual desire, lower urinary tract symptoms (LUTS), and quality of life in obese men.Men aged 30-65 years, with body mass index (BMI) ≥ 27.5 kg/m2, will be recruited from referrals to the Sports Medicine Centre in Changi General Hospital. The study will be conducted at the Sports Medicine Centre by trained medical investigators, dieticians and sports trainers.At baseline, 12 and 24 weeks, fasting glucose and lipids, insulin, testosterone, sex-hormone binding globulin, serum C-reactive protein and interleukin-6 are measured, endothelial function is measured by the non-invasive EndoPAT method, and validated questionnaires administered to assess changes in erectile function, sexual desire, LUTS and quality of life

Connect with a study center

  • Changi General Hospital

    Singapore, 529889
    Singapore

    Site Not Available

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