A Study of Vortioxetine (Lu AA21004) in Comparison to Agomelatine in Adults Suffering From Major Depression With Inadequate Response to Previous Medication

Inclusion Criteria:

• The patient is being treated with a serotonin reuptake inhibitor (SRI) antidepressant (monotherapy) that was prescribed to treat Major Depressive Episode (DSM-IV-TRcriteria)

• The response to the current SRI treatment is inadequate and patient agrees todiscontinue the current SRI at the baseline

• Montgomery Åsberg Depression Rating Scale (MADRS) total score ≥22 at the ScreeningVisit and Baseline

• The patient, if a woman, must: agree not to try to become pregnant during the study,AND use adequate, highly effective contraception

Exclusion Criteria:

• The patient has any current Axis I disorders (DSM-IV criteria) other than MajorDepressive Disorder (MDD), General Anxiety Disorder (GAD) and Social Anxiety Disorder (SAD)

• The patient is at significant risk of suicide

• The patient is currently receiving formal psychotherapy or other psychoactivemedications Other protocol-defined inclusion and exclusion criteria may apply.